@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR6_HUMAN: (2015-12-08 )
MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRSFLR
Atome Classification :
(20 SA)
-------.........10........20........30........--40........50........60.-----.......70---.--------------........80--------------.-.------------...----------------..--..---90........100.--------......110..---.---....120.------....---.------------------.130--.-.----.-----------------------.-----------------------....-------.140.......----150......---------.160------.........170.......180--...----....------190-----------.------------.......200.........---------210......-..220-.......230......----.240-...--....250.....--..260...-..-..270.......280.--------......290.......300.----..-..-.-.-310....-----.-----..320.......330.......340...-....----350..-.....360....------------...370.......380.......390.......400.......410.....-----...420.......430.......-.-.440---......-...450..------.-------..-..460.......470........480.......490-----.......500.....-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MQEPLLGAEGPDYDTFPEKPPPSPGDR
A
R
V
GTLQNKR
V
F
--
L
A
T
F
A
A
V
LGNFSF
G
Y
A
L
V
YTS
P
V
-----
I
P
A
L
E
R
SL----D--------------PD
L
H
L
T
K
S
Q
---------------
A
-
S
------------
W
F
G
----------------
S
V
--
F
T
---
L
GAAAG
G
L
S
A
M
I
L
N
--------
D
L
LG
R
K
L
S
I
M
F---S---AVPSAA
G
Y
------
A
L
M
A---G------------------
A
H
----
G
-
L
----
W
-----------------------
M
-----------------------
L
L
L
G
-------
R
T
L
T
GFAGG
L
T
----
A
A
C
I
P
V
Y
V
S
---------EI--------APPGVRGALGA
T
P
Q
L
M
A
V
F
G
S
L
--
S
L
Y
----
A
L
G
L
------LL------------
P
------------
W
R
W
LAVAG--E
A
P
V
L
I
M
I
L
---------
L
-
L
S
FMPNS-
P
R
F
L
L
-SRGR
D
E
E
A
L
R
A
L
A
W
LR----GT
D
V
-
D
V
H
--
W
E
F
E
Q
I
Q
D
N
V
R
R
--
Q
SSRVS
W
A
-EA-RAPHVC
R
P
I
T
V
A
L
L
M
R
--------
L
L
Q
Q
L
TG
I
T
P
I
L
V
Y
L
Q
S
I
FD----S
T
-
A
V
-
L
-L-PPKD
D
A
A
-----
I
-----
V
G
A
V
R
L
L
S
V
L
I
A
A
L
T
M
DLAG
R
K
V
L
L
F
V
S
-
A
A
I
M
----
F
AAN
L
-
T
L
G
L
Y
I
H
FGPRP------------LSPNSTAGLESE
S
W
G
D
L
A
Q
P
L
AAPA
G
Y
L
T
L
V
P
L
L
A
T
M
L
F
I
M
G
YAV-
G
W
G
P
I
-----
T
W
L
L
M
S
E
VL
P
L
RAR--
G
V
A
S
G
L
C
-
V
-
L
A
-----
S
W
L
T
A
F
-
V
L
T
K
S
F
L
P
------
V
-------
V
S
-TFGLQ
V
P
F
F
F
F
A
A
-
I
C
L
V
S
L
V
FTGCCVPETKGR
S
L
E
-----
Q
I
E
S
F
F
R
T
G
R
R
S
FLR-----------------------------
2
PsiBlast_PDB
95.02
28%
-131
- C3 -
4PYP
1
GTR1_HUMAN
A:
[11-455]
-------------------------------------------
R
L
M
--
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
----
N
T
G
V
-----
I
N
A
P
Q
K
V
I
----
E
--------------
E
--
F
Y
T
Q
T
W
---------------
V
-
H
------------
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
--
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
--------
N
R
F
G
R
R
N
S
M
L
M
---
M
---
N
L
L
A
F
V
S
A
------
V
L
M
G
---
F
------------------
S
K
LGK-
S
-
F
----
E
-----------------------
M
-----------------------
L
I
L
G
-------
R
F
I
I
G
V
Y
C
G
L
T
----
T
G
F
V
P
M
Y
V
G
---------
E
V
--------
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
--
I
A
Q
----
V
F
G
L
DSIMGN
K
D
------------
L
------------
W
P
L
L
L
S
I
I
--
F
I
P
A
L
L
Q
C
I
---------
V
-
L
P
F
C
P
E
S
-
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
----
G
T
-
A
-
D
V
T
--
H
D
L
Q
E
M
K
E
E
S
R
Q
MM
R
E
K
K
V
T
I
L
-
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
--------
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
----
K
A
-
G
V
-
Q
-
Q
-
P
V
Y
A
T
I
G
-----------
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
----
A
G
C
A
I
-
L
M
T
I
------------------------
A
L
A
L
L
E
Q
L
P
W
----------
M
S
Y
L
S
I
V
A
I
F
G
---
F
V
A
F
F
E
V
-
G
P
G
P
I
-----
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
--
P
A
A
I
A
V
A
-
G
-
F
S
-----
N
W
T
S
N
F
-
I
V
G
M
C
F
Q
Y
------
V
-------
E
Q
-
L
C
G
P
Y
V
-
F
I
I
F
T
V
-
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-------------------------------------------------------
6
PsiBlast_PDB
94.16
24%
-132
- C3 -
4GC0
5
XYLE_ECOLI
A:
[6-479]
----------------------------------------
N
S
S
Y
I
F
--
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-----
V
E
S
L
N
T
V
F
----
V
--------------
A
P
Q
N
L
S
E
S
A
---------------
A
N
S
------------
L
L
G
----------------
F
C
--
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
--------
N
R
F
G
R
R
D
S
L
K
I
---
A
---
A
V
-----
L
------
F
F
I
S
---
G
------------------
V
G
----
S
-
A
----
W
PELGFTSINPDNTVPVYLAGY
V
P
E
-----------------------
F
V
I
Y
-------
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
---------
E
L
--------
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
----
C
V
N
Y
------
F
I
------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
---------
L
-
L
Y
T
V
P
E
S
-
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
----
G
N
T
L
-
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
--
T
G
G
R
L
L
M
F
-
G
V
-
G
V
------
I
V
I
G
V
M
L
S
--------
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
-------
L
-
G
A
S
T
D
I
A
L
L
Q
T
I
I
-----
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
----
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
-----
C
W
V
L
L
S
E
I
F
P
N
A
I
R
--
G
K
A
L
A
I
A
-
V
-
A
A
-----
Q
W
L
A
N
Y
-
F
V
S
W
T
F
-
P
------
M
M
D
K
N
S
W
L
V
A
-
H
F
H
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
-----
E
L
E
A
L
W
E
-------------------------------------
4
PsiBlast_PDB
94.02
24%
-134
- C3 -
4GBY
5
XYLE_ECOLI
A:
[6-479]
----------------------------------------
N
S
S
Y
I
F
--
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-----
V
E
S
L
N
T
V
F
----
V
--------------
A
P
Q
N
L
S
E
S
A
---------------
A
N
S
------------
L
L
G
----------------
F
C
--
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
--------
N
R
F
G
R
R
D
S
L
K
I
---
A
---
A
V
-----
L
------
F
F
I
S
---
G
------------------
V
G
----
S
-
A
----
W
PELGFTSINPDNTVPVYLAGY
V
P
E
-----------------------
F
V
I
Y
-------
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
---------
E
L
--------
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
----
C
V
N
Y
------
F
I
------------
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
---------
L
-
L
Y
T
V
P
E
S
-
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
----
G
N
T
L
-
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
--
T
G
G
R
L
L
M
F
-
G
V
-
G
V
------
I
V
I
G
V
M
L
S
--------
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
-------
L
-
G
A
S
T
D
I
A
L
L
Q
T
I
I
-----
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
----
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
-----
C
W
V
L
L
S
E
I
F
P
N
A
I
R
--
G
K
A
L
A
I
A
-
V
-
A
A
-----
Q
W
L
A
N
Y
-
F
V
S
W
T
F
-
P
------
M
M
D
K
N
S
W
L
V
A
-
H
F
H
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
-----
E
L
E
A
L
W
E
-------------------------------------
5
PsiBlast_PDB
92.99
24%
-134
- C3 -
4GBZ
5
XYLE_ECOLI
A:
[6-479]
----------------------------------------
N
S
S
Y
I
F
--
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-----
V
E
S
L
N
T
V
F
----
V
--------------
A
P
Q
N
L
S
E
S
A
---------------
A
N
S
------------
L
L
G
----------------
F
C
--
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
--------
N
R
F
G
R
R
D
S
L
K
I
---
A
---
A
V
-----
L
------
F
F
I
S
---
G
------------------
V
G
----
S
-
A
----
W
PELGFTSINPDNTVPVYLAGY
V
P
E
-----------------------
F
V
I
Y
-------
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
---------
E
L
--------
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
----
C
V
N
Y
------
F
I
------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
---------
L
-
L
Y
T
V
P
E
S
-
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
----
G
N
T
L
-
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
--
T
G
G
R
L
L
M
F
-
G
V
-
G
V
------
I
V
I
G
V
M
L
S
--------
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
-------
L
-
G
A
S
T
D
I
A
L
L
Q
T
I
I
-----
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
----
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
-----
C
W
V
L
L
S
E
I
F
P
N
A
I
R
--
G
K
A
L
A
I
A
-
V
-
A
A
-----
Q
W
L
A
N
Y
-
F
V
S
W
T
F
-
P
------
M
M
D
K
N
S
W
L
V
A
-
H
F
H
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
-----
E
L
E
A
L
W
E
-------------------------------------
24
Fugue
92.59
25%
-120
* C3 *
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------
Y
N
S
S
Y
I
F
--
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-----
V
E
S
L
N
T
V
F
VAPQ
N
--------------
L
S
E
S
A
A
N
S
L
---------------
L
-
G
------------
F
C
V
----------------
A
S
--
A
L
---
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
--------
N
R
F
G
R
R
D
S
L
K
I
---
A
---
A
V
L
F
F
I
S
G
------
V
G
S
A
---
W
PELGFTSINPDNTVPVYL
A
G
----
Y
-
V
----
P
-----------------------
E
-----------------------
F
V
I
Y
-------
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
---------
E
L
--------
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
----
C
V
N
Y
------
F
I
------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
---------
L
-
L
Y
T
V
P
E
S
-
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
----
G
-
N
T
-
L
A
T
--
Q
A
V
Q
E
I
K
H
S
L
D
H
--
G
R
K
T
G
G
R
L
-
L
M
-
F
G
V
G
---
V
I
V
I
G
V
M
L
S
--------
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
L
-
G
A
S
T
-
D
-
I
A
L
L
Q
T
I
-----
I
-----
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
----
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
Q
A
P
-----------------------------------------
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
-----
C
W
V
L
L
S
E
I
F
P
N
A
I
R
--
G
K
A
L
A
I
A
-
V
-
A
A
-----
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
-------
V
A
-
H
F
H
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
-----
E
L
E
A
L
W
E
-------------------------------------
8
PsiBlast_PDB
91.48
26%
-123
- C3 -
4ZW9
4
?
A:
[34-488]
------------------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
-----
I
N
A
P
E
K
I
I
----
K
E
F
I
T
K
T
L
T
D
K
GNAP
P
S
E
V
L
L
T
S
L
---------------
W
-
S
------------
L
S
V
----------------
A
I
--
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
--------
N
R
F
G
R
R
N
S
M
L
I
---
V
---
N
L
L
A
V
T
G
G
------
C
F
M
G
L
CK
V
------------------
A
K
----
S
-
V
----
E
-----------------------
M
-----------------------
L
I
L
G
-------
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
---------
E
I
--------
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
----
G
L
E
F
------
I
L
------------
G
SEEL--------
W
P
L
L
L
G
F
T
--
I
L
P
A
I
L
Q
S
A
---------
A
-
L
P
F
C
P
E
S
-
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
----
G
T
Q
--
D
V
S
--
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
-
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
--------
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
----
D
A
-
G
V
-
Q
-
E
-
P
I
Y
A
T
I
G
-----------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
----
F
C
S
T
L
M
T
V
S
L
L
-------------------
L
K
D
N
Y
N
G
--------------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
-----
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
--
P
A
A
M
A
V
A
-
G
-
C
S
-----
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
------
A
-------
A
H
-
Y
L
G
A
Y
V
-
F
I
I
F
T
G
-
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
-----
D
I
T
R
A
F
E
G
Q
A
H
---------------------------------
9
PsiBlast_PDB
89.96
26%
-123
- C3 -
4ZWB
1
?
A:
[34-488]
------------------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
-----
I
N
A
P
E
K
I
I
----
K
E
F
I
T
K
T
L
T
D
K
GNAP
P
S
E
V
L
L
T
S
L
---------------
W
-
S
------------
L
S
V
----------------
A
I
--
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
--------
N
R
F
G
R
R
N
S
M
L
I
---
V
---
N
L
L
A
V
T
G
G
------
C
F
M
G
L
CK
V
------------------
A
K
----
S
-
V
----
E
-----------------------
M
-----------------------
L
I
L
G
-------
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
---------
E
I
--------
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
----
G
L
E
F
------
I
L
------------
G
SEEL--------
W
P
L
L
L
G
F
T
--
I
L
P
A
I
L
Q
S
A
---------
A
-
L
P
F
C
P
E
S
-
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
----
G
T
Q
--
D
V
S
--
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
-
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
--------
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
----
D
A
-
G
V
-
Q
-
E
-
P
I
Y
A
T
I
G
-----------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
----
F
C
S
T
L
M
T
V
S
L
L
-------------------
L
K
D
N
Y
N
G
--------------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
-----
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
--
P
A
A
M
A
V
A
-
G
-
C
S
-----
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
------
A
-------
A
H
-
Y
L
G
A
Y
V
-
F
I
I
F
T
G
-
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
-----
D
I
T
R
A
F
E
G
Q
A
H
---------------------------------
25
Fugue
89.64
28%
-144
- C3 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
------------------------------------------
S
Y
I
F
--
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-----
V
E
S
L
N
T
V
F
----
V
--------------
A
P
Q
N
L
S
E
S
A
---------------
A
N
S
------------
L
L
G
----------------
F
C
--
V
--------
A
S
A
L
I
G
C
I
I
G
--------
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
---
S
L
K
I
A
A
V
L
------
F
F
I
S
---
G
------------------
V
G
----
S
-
A
----
W
-----------------------
P
ELGFTSINPDNTVPVYLAGY
V
P
E
F
V
I
Y
-------
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
---------
E
L
--------
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
----
C
V
N
Y
------
F
I
A
R
SGD
A
S
W
L
N
T
D
G
------------
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
---------
L
-
L
Y
T
V
P
E
S
-
P
R
W
L
M
-
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
----------------------------------------
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
--------
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
GA
S
T
-
D
I
-
A
-
L
----
L
Q
T
I
-----
I
-----
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
----
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
Q
A
P
G
-----------------------------------------
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
-----
C
W
V
L
L
S
E
I
F
P
N
A
I
R
--
G
K
A
L
A
I
A
-
V
-
A
A
-----
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
-
V
A
-
H
F
H
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
--------------------------------------------------
10
PsiBlast_PDB
89.22
26%
-124
- C3 -
4ZWC
3
?
A:
[34-488]
------------------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
-----
I
N
A
P
E
K
I
I
----
K
E
F
I
T
K
T
L
T
D
K
GNAP
P
S
E
V
L
L
T
S
L
---------------
W
-
S
------------
L
S
V
----------------
A
I
--
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
--------
N
R
F
G
R
R
N
S
M
L
I
---
V
---
N
L
L
A
V
T
G
G
------
C
F
M
G
L
CK
V
------------------
A
K
----
S
-
V
----
E
-----------------------
M
-----------------------
L
I
L
G
-------
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
---------
E
I
--------
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
----
G
L
E
F
------
I
L
------------
G
SEEL--------
W
P
L
L
L
G
F
T
--
I
L
P
A
I
L
Q
S
A
---------
A
-
L
P
F
C
P
E
S
-
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
----
G
T
Q
--
D
V
S
--
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
-
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
--------
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
----
D
A
-
G
V
-
Q
-
E
-
P
I
Y
A
T
I
G
-----------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
----
F
C
S
T
L
M
T
V
S
L
L
-------------------
L
K
D
N
Y
N
G
--------------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
-----
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
--
P
A
A
M
A
V
A
-
G
-
C
S
-----
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
------
A
-------
A
H
-
Y
L
G
A
Y
V
-
F
I
I
F
T
G
-
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
-----
D
I
T
R
A
F
E
G
Q
A
H
---------------------------------
7
PsiBlast_PDB
88.82
26%
-120
- C3 -
5C65
8
?
A:
[12-466]
------------------------------------------------
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
----
N
T
G
V
-----
I
N
A
P
E
K
I
I
----
K
--------------
E
F
I
Q
K
T
L
T
D
---------------
K
-
G
NAPPS
E
V
L
L
T
S
L
W
S
L
----------------
S
V
A
I
F
S
---
V
G
G
M
I
G
S
F
S
V
G
L
F
V
--------
N
R
F
G
R
R
N
S
M
L
I
---
V
---
N
L
L
A
V
T
G
G
------
C
F
M
G
L
C
K
V
------------------
A
K
----
S
-
V
----
E
-----------------------
M
-----------------------
L
I
L
G
-------
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
---------
E
I
--------
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
----
G
L
E
F
------
I
L
------------
G
SEEL--------
W
P
L
L
L
G
F
T
--
I
L
P
A
I
L
Q
S
A
---------
A
-
L
P
F
C
P
E
S
-
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
----
G
T
Q
--
D
V
S
--
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
-
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
--------
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
----
D
A
--------
P
I
Y
A
T
I
G
-----------
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
----
F
C
S
T
L
-
M
---------------------------
T
V
S
L
L
L
K
D
---------------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
-
G
P
G
P
I
-----
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
--
P
A
A
M
A
V
A
-
G
-
C
S
-----
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
------
A
-------
A
H
-
Y
L
G
A
Y
V
-
F
I
I
F
T
G
-
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
-----
D
I
T
R
A
F
E
G
Q
A
----------------------------------
3
PsiBlast_PDB
87.32
24%
-147
- C3 -
4JA4
-
XYLE_ECOLI
A:
[9-479]
-------------------------------------------
Y
I
F
--
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
-----
V
E
S
L
N
T
V
F
----
V
--------------
A
P
Q
N
L
S
E
S
A
---------------
A
N
S
------------
L
L
G
----------------
F
C
--
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
--------
N
R
F
G
R
R
D
S
L
K
I
---
A
---
A
V
-----
L
------
F
F
I
S
---
G
------------------
V
G
----
S
-
A
----
W
PELGF
T
S
I
N
P
D
N
T
V
PVYLAGY
V
P
E
-----------------------
F
V
I
Y
-------
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
---------
E
L
--------
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
--
L
V
Y
----
C
V
N
Y
------
F
I
------------
A
RSGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
--
C
I
P
A
L
L
F
L
M
---------
L
-
L
Y
T
V
P
E
S
-
P
R
W
L
M
-----
Q
E
Q
A
E
G
I
L
R
K
I
M
----
G
N
T
L
-
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
----------
M
F
-
G
V
-
G
V
------
I
V
I
G
V
M
L
S
--------
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------------------LLQ
T
I
I
-----
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
----
A
I
G
M
F
-
S
L
G
T
A
F
Y
-------------------------------------
T
Q
A
P
G
----
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
-----
C
W
V
L
L
S
E
I
F
P
N
A
I
R
--
G
K
A
L
A
I
A
-
V
-
A
A
-----
Q
W
L
A
N
Y
-
F
V
S
W
T
F
-
P
------
M
M
DKNSW-------
N
G
F
S
Y
W
I
Y
G
C
-
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
-----
E
L
E
A
L
W
E
-------------------------------------
1
PsiBlast_PDB
80.62
29%
-127
- C3 -
4LDS
-
?
A:
[33-427]
-----------------------------------------------------------------------------------
I
----
H
--------------
K
D
I
P
L
N
S
T
T
---------------
E
-
G
------------
I
V
V
----------------
S
S
--
M
L
---
I
G
A
I
V
G
A
G
S
S
G
P
L
A
--------
D
K
L
G
R
R
R
L
V
M
L
---
I
---
A
I
V
F
I
I
G
A
------
L
I
L
A
---
A
------------------
S
T
----
N
-
L
----
A
-----------------------
L
-----------------------
L
I
I
G
-------
R
L
I
I
G
L
A
V
G
G
S
----
M
S
T
V
P
V
Y
L
S
---------
E
M
--------
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
--
A
A
Y
L
V
N
Y
A
F
A
D
------
I
E
------------
G
------------
W
R
W
M
L
G
L
A
--
V
V
P
S
V
I
L
L
V
---------
G
-
I
Y
F
M
P
E
S
-
P
R
W
L
L
-
E
N
-
R
N
E
E
A
A
R
Q
V
M
K
I
T
----
Y
D
D
S
-
E
I
D
--
K
E
L
K
E
M
K
E
--
I
N
--
A
I
S
E
S
T
W
T
-
V
I
-
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
--------
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
----
K
A
-
G
L
-------
G
E
A
A
S
-----
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
-
N
I
G
M
----
I
A
S
L
L
-
I
M
A
I
L
I
W
----------------------
T
I
G
I
A
S
S
A
W
----------------
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
-
S
W
G
P
V
-----
L
W
V
M
L
P
E
L
F
P
M
R
A
R
--
G
A
A
T
G
I
S
-
A
-
L
V
-----
L
N
I
G
T
L
-
I
V
S
L
-
F
F
P
------
I
-------
L
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
-
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
-----------------------------------------------------
30
Fugue
69.43
21%
-100
- C3 -
3WDO
-
?
A:
[1-453]
------------------
D
Y
----
K
M
T
P
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
--
G
M
F
M
V
L
P
V
L
T
T
-
Y
G
M
A
L
Q
G
A
S
----------------------------------------
E
A
L
---------------
I
-
G
------------
I
A
I
----------------
G
I
--
Y
G
---
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
--------
D
R
I
G
R
K
P
L
I
V
G
---
G
---
L
A
V
F
A
A
G
S
------
V
I
A
A
---
L
------------------
S
D
----
S
-
I
----
W
-----------------------
G
-----------------------
I
I
L
G
-------
R
A
L
Q
G
S
--
G
A
I
----
A
A
A
V
M
A
L
L
S
---------
D
L
TREQN
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
--
I
T
H
----
K
L
G
L
------
H
A
------------
L
------------
F
W
M
I
A
I
L
A
--
T
T
G
I
A
L
T
I
W
---------
V
-
V
---
P
N
S
-
S
T
H
V
L
-
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
----
E
P
R
L
L
K
L
N
--
F
G
I
M
C
L
H
M
L
L
M
S
--
T
F
V
A
L
P
G
Q
-
L
A
-
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
--------
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
-----------------
K
R
K
M
K
Q
V
-----
F
-----
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
-
Q
L
F
F
----
V
A
F
N
L
-
M
E
A
L
L
P
S
L
I
S
K
E
----------------------------------
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
-
G
G
S
L
G
-----
G
W
I
D
G
M
----
F
D
G
Q
--
G
V
F
L
A
G
A
-
M
-
L
A
-----
A
V
W
L
A
V
-
A
S
T
M
K
E
P
P
------
Y
-------
V
S
-
S
L
R
I
E
I
P
A
D
I
A
A
N
-
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
-
V
T
N
R
F
E
V
E
Q
A
I
R
QAL-----------------------
26
Fugue
63.70
12%
-111
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
-------------------
F
K
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
--
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
-----
L
V
--------------------------
E
Q
G
F
S
R
G
D
---------------
L
-
G
------------
F
A
L
----------------
S
G
--
I
S
---
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
--------
D
R
S
N
P
R
V
F
L
P
A
---
G
---
L
I
L
A
A
A
V
M
------
L
F
M
G
---
F
------------------
V
P
----
W
-
A
T
S
SI
A
-----------------------
V
-----------------------
M
F
V
L
-------
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
---------
H
W
--------
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
--
I
-------------------------------------------------------
P
P
L
L
F
L
L
---------
G
-
M
A
W
F
N
D
W
-
H
A
A
L
Y
-
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
----
M
R
D
T
-
P
Q
S
--
C
G
L
P
P
I
E
E
Y
K
N
D
--
T
A
K
Q
I
F
M
Q
-
Y
V
-
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
--------
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K
H
--------------
F
A
L
D
K
S
S
-----
W
-----
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
-
G
A
T
G
----
V
F
F
M
T
-
L
V
T
I
A
T
I
V
Y
W
M
N
------------
P
A
G
N
-------------------------
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
-
G
P
V
M
L
-----
I
G
L
H
A
L
E
L
A
P
K
K
A
A
--
G
T
A
A
G
F
T
-
G
-
L
F
-----
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
------
Y
-------
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
-
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
-----
L
L
Q
E
L
V
P
-------------------------------------
28
Fugue
59.61
17%
-96
- C2 -
4WW4
1
?
A:
[3-458]
-------------------------
Q
I
S
E
V
R
G
N
T
------
R
D
H
R
T
A
--
A
H
T
H
I
K
G
L
G
L
N
S
S
G
I
A
--------------------------------------------
E
K
Q
A
---------------
A
-
G
------------
F
V
G
----------------
Q
----------
C
A
A
R
E
A
C
G
V
V
V
D
--------
L
I
K
A
H
K
M
---------------
A
G
R
G
------
V
L
L
A
---
G
------------------
G
P
----
G
-
T
----
G
-----------------------
K
-----------------------
T
A
L
A
-------
L
A
I
S
Q
E
L
G
T
K
I
----
P
-
F
C
P
I
T
G
S
---------
E
I
--------
Y
S
T
E
V
K
----
K
T
E
V
L
M
E
N
F
R
R
----------
A
I
G
L
------
R
V
------------
R
------------
E
T
K
D
V
Y
E
G
--
E
V
S
T
L
L
I
G
L
----------------
K
S
-
A
R
G
Q
K
-
L
D
Q
K
E
R
V
Q
V
G
D
V
I
Y
I
E
----
T
N
T
G
-
A
C
R
----
S
D
A
Y
A
T
E
F
D
L
--
E
A
E
E
Y
V
P
I
-
P
K
-
G
E
V
H
K
K
K
E
I
V
Q
D
V
T
L
H
--------
D
L
D
V
A
N
A
R
P
D
I
I
S
M
M
G
Q
L
M
K
----
P
K
------
M
-
T
E
I
T
D
K
L
-----
R
-----
M
E
I
N
K
V
V
Q
K
Y
I
N
Q
G
V
A
E
L
I
P
G
--
V
L
F
I
D
-
E
A
H
M
LD
I
E
C
F
T
Y
L
-
N
K
A
L
E
S
P
I
A
P
I
V
------------
V
L
A
S
N
R
G
I
A
T
I
R
G
A
D
D
L
K
A
A
H
G
I
P
P
D
F
L
Q
R
L
L
I
I
P
T
------------
H
P
Y
-----
E
P
D
E
I
R
R
I
V
R
I
R
A
Q
--
T
E
G
V
Q
L
--------------------
T
D
A
A
V
D
------
R
-------
V
A
-
E
H
G
V
R
I
S
L
R
Y
C
L
Q
L
L
A
P
A
S
I
L
A
R
V
N
G
R
T
Q
V
D
V
Q
D
I
A
-----
E
A
E
E
L
F
L
D
A
R
R
S
A
N
I
L
T
S
TGGLH---------------------
13
HHSearch
59.19
12%
-119
- C3 -
1PW4
-
GLPT_ECOLI
A:
[27-449]
--------------------------------------------
R
W
--
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
-----
M
P
Y
L
V
-----------------------
E
Q
G
F
S
R
G
D
---------------
L
-
G
------------
F
A
L
----------------
S
G
--
I
S
---
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
--------
D
R
S
N
P
R
V
F
L
P
A
---
G
---
L
I
L
A
A
A
V
M
------
L
F
M
G
---
F
------------------
V
P
W
A
T
S
S
-
I
----
A
-----------------------
V
-----------------------
M
F
V
L
-------
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
---------
H
W
--------
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
--
I
P
P
----
L
L
F
L
L
G
M
AW-
F
N
------------
D
------------
W
H
A
A
L
Y
M
P
--
A
F
C
A
I
L
V
A
L
---------
F
A
F
A
M
M
R
D
T
-
P
Q
S
C
G
-
L
P
P
I
E
E
Y
K
N
D
----------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
-
P
N
K
L
L
W
-----
Y
I
A
I
A
--------
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
----
E
V
K
H
F
-
A
L
D
-
K
S
S
W
A
Y
F
-----
L
-----
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
-
V
F
F
M
----
T
L
V
T
I
A
T
I
V
Y
W
M
N
P
-
A
----------------------------------------
G
N
P
T
V
D
M
I
C
M
I
V
--
I
G
F
L
I
Y
G
P
V
M
L
-----
I
G
L
H
A
L
E
L
A
P
K
K
A
A
--
G
T
A
A
G
F
T
-
G
-
L
F
-----
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
------
T
-------
V
D
-
F
F
G
W
D
G
G
F
M
V
M
I
G
-
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
-----
L
L
Q
E
L
V
P
-------------------------------------
33
Fugue
58.95
17%
-121
- C1 -
3VSM
1
OE66_NPVAC
A:
[27-659]
N
I
Q
E
L
Q
N
F
E
R
W
F
K
N
N
L
S
Y
S
F
S
Q
K
A
E
K
V
V
N
P
N
R
N
W
N
D
N
T
V
F
D
N
L
S
P
W
TS
V
P
D
F
G
T
V
C
H
T
L
-
I
G
Y
C
V
R
Y
N
N
T
S
DTLYQ
N
P
E
L
A
Y
N
L
----
I
--------------
N
G
L
R
I
I
C
S
K
LPDPPPHQQAPWGPV
A
-
D
------------
W
Y
H
----------------
F
T
--
I
T
---
M
P
E
V
F
M
N
I
T
I
V
L
N
E
TQH
Y
D
E
A
A
S
L
T
R
Y
W
L
G
L
Y
L
---
P
---
T
A
V
N
S
M
G
W
H
R
T
A
G
N
S
M
R
M
---
G
------------------
V
P
----
Y
-
T
----
Y
-----------------------
S
-----------------------
Q
M
L
R
GYS
L
A
Q
I
R
Q
E
Q
G
I
Q
E
I
L
N
----
T
I
A
F
P
Y
V
T
Q
GNGLHVDS
I
Y
I
--------
D
H
I
D
V
R
-
A
Y
G
Y
L
I
N
S
Y
F
T
F
A
Y
Y
--
T
Y
Y
FGDE
V
I
N
T
------
V
G
------------
L
------------
T
R
A
I
E
N
V
G
SP
E
G
V
V
V
P
G
V
M
SRNGTLYSN
V
-
I
G
N
F
I
T
Y
-
P
L
A
V
H
-
S
A
D
Y
S
----
K
V
L
T
K
L
S
KT
Y
Y
G
S
V
V
-
G
V
T
--
N
R
L
A
Y
Y
E
S
D
P
T
N
--
N
I
Q
A
P
L
W
T
-
M
A
-
R
R
I
W
N
R
R
G
R
I
I
N
Y
N
A
N
TVSFESGI
I
L
Q
S
L
N
G
I
M
R
I
----
P
S
G
T
T
----
S
T
-
Q
S
-
F
-
R
-
P
T
I
G
Q
T
A
-----
I
-----
A
K
T
D
T
A
G
A
I
L
V
Y
A
K
F
A
E
M
N
N
----
L
Q
F
K
-
S
C
T
L
----
F
Y
D
H
G
-
M
F
Q
L
Y
Y
N
I
G
V
E
P
NSLNN
T
N
G
R
V
I
V
L
S
R
D
T
S
V
N
T
N
D
L
S
F
E
A
Q
R
I
N
N
N
N
S
S
E
G
T
T
F
N
G
V
V
C
H
R
V
P
I
T
N
I
N
V
-
P
S
L
T
V
R
S
PNS
S
V
E
L
V
E
Q
I
I
S
F
Q
T
M
Y
T
A
T
A
S
A
C
Y
-
K
-
L
N
VEGHS
D
S
L
R
A
F
R
V
N
S
D
E
N
I
Y
------
V
-------
N
V
-
G
N
G
V
K
A
L
F
N
Y
P
W
V
-
M
V
K
E
N
N
K
V
S
F
M
S
A
N
E
D
T
T
I
P
F
S
-----
V
I
M
N
S
F
T
S
I
G
E
P
A
L
Q
Y
S
P
SNCFVYGN
G
F
K
L
NNSTF
D
L
Q
F
I
F
E
I
V
27
Fugue
55.67
11%
-105
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
----------------------------------------
M
Y
Y
L
K
N
--
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
-----
F
P
I
W
---
L
----
H
--------------
D
I
N
H
I
S
K
S
D
---------------
T
-
G
------------
I
I
F
----------------
A
A
--
I
S
---
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
--------
D
K
L
G
L
R
K
Y
L
L
W
---
I
---
I
T
G
M
L
V
M
F
------
A
P
F
F
---
I
------------------
F
I
----
F
-
G
----
P
-----------------------
L
-----------------------
L
Q
Y
N
-------
I
L
V
G
S
I
V
G
G
I
Y
----
L
G
F
C
F
N
-------------------------------
A
G
A
P
A
V
E
A
F
I
E
K
V
--
S
R
R
----
S
N
F
E
------
F
G
------------
R
------------
A
R
M
F
G
C
V
G
--
W
A
L
G
A
S
I
V
G
---------
I
-
M
F
T
I
N
N
Q
-
F
V
F
W
L
-
G
S
G
C
A
L
I
L
A
V
L
L
F
F
A
K
----
T
D
A
P
-
S
S
A
--
T
V
A
N
A
V
G
A
N
H
S
A
--
F
S
L
K
L
A
L
E
-
L
F
-
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
--------
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
T
----
G
E
-
Q
G
-
T
-
R
-
V
F
G
Y
V
T
T
-----
M
-----
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
-
G
T
I
M
----
S
V
R
I
I
-
G
S
S
F
A
----------------------------------------------
T
S
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
-
F
L
L
V
G
-----
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
--
A
T
I
Y
L
V
C
-
F
C
F
F
-----
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
------
M
-------
Y
E
-
S
I
G
F
Q
G
A
Y
L
V
L
G
L
-
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
-----
R
R
Q
V
N
E
V
A
------------------------------------
17
HHSearch
49.84
12%
-104
- C3 -
2CFQ
-
LACY_ECOLI
A:
[23-392]
----------------------------------------------------------------
M
G
A
Y
F
P
F
-----
F
P
I
W
L
H
D
---------------------
I
N
H
I
S
K
S
D
---------------
T
-
G
------------
I
I
F
----------------
A
A
--
I
S
---
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
--------
D
K
L
G
L
R
K
Y
L
L
W
---
I
I
T
G
M
L
V
M
F
A
P
F
------
F
I
F
I
---
F
------------------
G
P
----
L
L
Q
----
Y
-----------------------
N
-----------------------
I
L
V
G
-------
S
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
---------
K
V
--------
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
--
L
G
A
----
S
I
V
G
I
M
F
---
T
I
------------
N
------------
N
Q
F
V
F
W
L
G
--
S
G
C
A
L
I
L
A
V
---------
L
-
L
F
F
A
K
T
D
A
P
S
S
A
---
T
V
A
N
A
V
G
-------------
A
N
--
H
-----
S
A
F
S
------------
L
K
L
A
L
E
L
F
-
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
-
V
--------
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
A
----
T
G
-
E
Q
-
G
-
T
R
V
F
G
Y
V
T
T
-----
M
-----
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
-
G
T
I
M
----
S
V
R
I
I
-
G
S
S
F
A
----
T
----------------------------------------
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
--
L
L
V
G
-----
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
--
A
T
I
Y
L
V
C
F
C
-
F
F
-----
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
------
M
-------
Y
E
-
S
I
G
F
Q
G
A
Y
L
V
L
G
L
-
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
-----
R
R
Q
V
N
E
V
A
------------------------------------
18
HHSearch
42.11
19%
-139
- C3 -
3WDO
-
?
A:
[53-189]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
I
-----
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
-
L
A
V
F
----
A
A
G
S
V
-
I
A
A
L
S
D
--------------------------------------------
S
-
I
W
G
I
I
L
G
R
A
L
--
Q
G
S
G
A
--
I
A
A
A
-----
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
--
T
K
A
M
A
F
I
-
G
-
V
S
-----
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
------
I
-------
T
H
-
K
L
G
L
H
A
L
F
W
M
I
A
I
-
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
-----
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
-----------------------------