@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR4_HUMAN: (2015-12-08 )
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
Atome Classification :
(20 SA)
--.........10........20........30........40........50........60........70........80........90........100---------.......110.......120.----------.....---------------.130..-..-----....140.......150.......160.......170.......180......-.190-----.....------..------..200.......210.....-..--220.......230.......240.......250.......260--......-..270.......280..-.....290.......300.......310.....--..320...--......330.......340.......350.......360...-....370.......380.......390...--....400.......410.-......420.......430-......-------.440----.-------.....-.-..450....--...460.......470.......480.......490.......500.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MP
S
G
F
Q
Q
IGSEDGEP
P
Q
Q
R
V
T
G
T
L
V
L
A
V
F
S
A
V
L
G
S
L
QFGYNIGVINA
P
Q
K
V
I
E
Q
SYNETWLGRQGPEGPSSIPP
G
T
L
T
T
L
W
A
L
S
V
A
I
F
S
V
G
G
M
I
S
S
F
L
I
G
I
I
---------
S
Q
W
L
G
R
K
R
A
M
L
V
N
N
V
L
A
V
L
G
G
----------
S
L
M
G
L
---------------
A
N
A
-
A
A
-
S
Y
-----
E
M
L
I
L
G
R
F
L
I
G
A
Y
S
G
L
TSG
L
V
P
M
Y
V
GEI
A
P
T
H
L
R
G
A
L
G
T
L
N
Q
L
A
I
V
I
G
I
L
I
A
Q
-
V
L
-------
G
L
E
S
L
------
L
G
------
T
A
S
L
W
P
L
L
L
G
L
T
V
L
P
A
L
L
Q
L
-
V
L--LPFCPESP
R
Y
L
Y
I
IQNLE
G
P
A
R
K
S
L
K
R
LTG
W
A
D
V
S
G
V
L
A
E
L
K
---
D
E
K
R
K
L
-
E
R
ER
P
L
S
L
L
Q
L
L
GSRTH-RQ
P
L
I
I
A
V
V
L
Q
L
S
Q
Q
LSG
I
N
A
V
F
Y
YST
S
I
F
ETA--GVG--Q
P
A
--
Y
A
T
I
G
A
G
V
V
N
T
V
F
T
L
V
S
V
L
L
V
E
RAGR
R
T
L
H
L
LG
L
A
G
M
C
G
C
A
I
-
L
M
T
V
A
L
L
L
L
E
RVP
A
M
S
Y
V
S
I
V
A
I
F
G
F
V
A
F
F
--EIGPGP
I
P
W
F
I
V
A
E
L
F
SQ-GPRP
A
A
M
A
V
AGFSNWTS
N
F
-
I
I
G
M
G
F
-------
Q
Y
------
V
-------
A
E
AM
G
-
P
-
Y
V
F
L
L
F
A
V
L
--
L
L
G
F
F
I
F
T
F
L
RVPETRGR
T
F
D
Q
I
S
A
A
F
HR
T
P
S
L
L
E
Q
EVKPSTE
L
E
YLGPDEND
2
PsiBlast_PDB
90.93
59%
-124
- C1 -
4ZW9
4
?
A:
[23-488]
----------------
M
G
T
Q
K
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
-
L
T
D
K
G
N
A
P
P
S
E
V
---
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
----------
C
F
M
G
L
---------------
C
K
V
-
A
K
-
S
V
-----
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
-
I
F
-------
G
L
E
F
I
------
L
G
------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
---
D
E
S
A
R
M
-
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
-
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
V
Q
--
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
--
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
-------
P
S
------
A
-------
A
H
Y
L
G
-
A
-
Y
V
F
I
I
F
T
G
F
--
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
---------------------
3
PsiBlast_PDB
90.65
59%
-125
- C1 -
4ZWB
1
?
A:
[25-488]
------------------
T
Q
K
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
-
L
T
D
K
G
N
A
P
P
S
E
V
---
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
----------
C
F
M
G
L
---------------
C
K
V
-
A
K
-
S
V
-----
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
-
I
F
-------
G
L
E
F
I
------
L
G
------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
---
D
E
S
A
R
M
-
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
-
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
V
Q
--
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
--
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
-------
P
S
------
A
-------
A
H
Y
L
G
-
A
-
Y
V
F
I
I
F
T
G
F
--
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
---------------------
12
PsiBlast_CBE
90.60
59%
-128
- C1 -
4ZWC
2
?
B:
[25-488]
------------------
T
Q
K
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
-
L
T
D
K
G
N
A
P
P
S
E
V
---
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
----------
C
F
M
G
L
---------------
C
K
V
-
A
K
-
S
V
-----
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
-
I
F
-------
G
L
E
F
I
------
L
G
------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
---
D
E
S
A
R
M
-
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
-
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
V
Q
--
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
--
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
-------
P
S
------
A
-------
A
H
Y
L
G
-
A
-
Y
V
F
I
I
F
T
G
F
--
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
---------------------
5
PsiBlast_PDB
90.27
60%
-127
- C1 -
5C65
8
?
A:
[5-466]
--------------------
K
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
-
L
T
D
K
G
N
A
P
P
S
E
V
---
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
----------
C
F
M
G
L
---------------
C
K
V
-
A
K
-
S
V
-----
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
-
I
F
-------
G
L
E
F
I
------
L
G
------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
---
D
E
S
A
R
M
-
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
-
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--------
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
--
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
-------
P
S
------
A
-------
A
H
Y
L
G
-
A
-
Y
V
F
I
I
F
T
G
F
--
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
----------------------
4
PsiBlast_PDB
89.75
59%
-126
- C1 -
4ZWC
3
?
A:
[25-488]
------------------
T
Q
K
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
-
L
T
D
K
G
N
A
P
P
S
E
V
---
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
----------
C
F
M
G
L
---------------
C
K
V
-
A
K
-
S
V
-----
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
-
I
F
-------
G
L
E
F
I
------
L
G
------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
---
D
E
S
A
R
M
-
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
-
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
V
Q
--
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
--
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
-------
P
S
------
A
-------
A
H
Y
L
G
-
A
-
Y
V
F
I
I
F
T
G
F
--
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
---------------------
1
PsiBlast_PDB
89.75
64%
-139
- C1 -
4PYP
1
GTR1_HUMAN
A:
[9-455]
----------------------
T
G
R
L
M
L
A
V
G
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
T
Q
T
W
V
H
R
Y
G
----
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
----------
V
L
M
G
F
---------------
S
K
L
-
G
K
-
S
F
-----
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
-
V
F
-------
G
L
D
S
I
------
M
G
------
N
K
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
-
I
V
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
---
E
E
S
R
Q
M
-
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
-
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
--
G
V
Q
--
Q
P
V
--
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
-
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
--
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
-
I
V
G
M
C
F
-------
Q
Y
------
V
-------
E
Q
L
C
G
-
P
-
Y
V
F
I
I
F
T
V
L
--
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------------------------------
13
PsiBlast_CBE
89.50
60%
-127
- C1 -
5C65
7
?
B:
[6-466]
---------------------
V
T
P
A
L
I
F
A
I
T
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
-
L
T
D
K
--
A
P
P
S
E
V
---
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
---------
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
----------
C
F
M
G
L
---------------
C
K
V
-
A
K
-
S
V
-----
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
-
I
F
-------
G
L
E
F
I
------
L
G
------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
--
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
---
D
E
S
A
R
M
-
S
---
Q
V
T
V
L
E
L
F
R
V
S
S
Y
-
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
-------
E
P
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
-
L
M
T
V
S
L
L
L
K
D
N
Y
----
F
V
C
I
G
A
I
L
V
F
V
A
F
F
--
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
-
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
-------
P
S
------
A
-------
A
H
Y
L
G
-
A
-
Y
V
F
I
I
F
T
G
F
--
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
----------------------
26
Fugue
70.10
26%
-111
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
--------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
----------
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
---------
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
----------
V
G
S
A
W
PELGFTSINPDNTVP
V
Y
L
-
A
G
-
Y
V
-----
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
-
C
V
-------
N
Y
F
I
A
R
S
GD
A
S
W
L
------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
P
E
S
P
R
W
L
M
S
-
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
---
H
S
L
D
H
G
-
R
K
T
G
G
R
L
L
M
F
------
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
GA
S
T
D
--
I
A
L
--
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
----
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
-------
P
M
M
D
K
N
S
W
L
-------
V
A
H
F
H
-
N
G
F
S
Y
W
I
Y
G
C
M
--
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-------------------------
27
Fugue
67.41
29%
-134
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
-----------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
----
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
---------
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
----------
V
G
S
A
W
PELGFTSINPDNTVP
V
Y
L
-
A
G
-
Y
V
-----
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
-
C
V
-------
N
Y
F
I
A
------
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
P
E
S
P
R
W
L
M
------------------------
T
L
A
T
Q
A
---
V
Q
E
I
K
H
-
S
L
D
R
L
--------
L
M
F
G
-
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
--
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
-
S
L
G
T
A
F
Y
T
Q
A
P
----
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
-------
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
-
G
-
F
S
Y
W
I
Y
G
C
M
--
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
---------------------------------
7
PsiBlast_PDB
65.97
27%
-110
- C1 -
4GBY
5
XYLE_ECOLI
A:
[17-479]
--------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
----
E
S
L
N
T
V
F
V
A
------
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
---------
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGF
T
S
I
N
P
---------------
D
N
T
-
V
P
-
V
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
-
C
V
N
Y
F
I
A
R
S
G
D
A
S
W
------
L
N
------
T
D
G
-
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
-
G
G
R
-----
L
L
M
F
G
V
G
V
-----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
--
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
-------
A
H
F
H
N
-
G
-
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
--
V
P
E
T
K
G
K
T
L
E
E
L
E
A
-------
L
W
E
------------------
9
PsiBlast_PDB
65.63
27%
-109
- C1 -
4GC0
5
XYLE_ECOLI
A:
[17-479]
--------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
----
E
S
L
N
T
V
F
V
A
------
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
---------
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
WPELGF
T
S
I
N
P
---------------
D
N
T
-
V
P
-
V
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
-
C
V
N
Y
F
I
A
R
S
G
D
A
S
W
------
L
N
------
T
D
G
-
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
-
G
G
R
-----
L
L
M
F
G
V
G
V
-----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
--
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
-------
A
H
F
H
N
-
G
-
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
--
V
P
E
T
K
G
K
T
L
E
E
L
E
A
-------
L
W
E
------------------
8
PsiBlast_PDB
65.25
27%
-110
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[17-479]
--------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
----
E
S
L
N
T
V
F
V
A
------
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
---------
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
PELGF
T
S
I
N
P
---------------
D
N
T
-
V
P
-
V
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
-
C
V
N
Y
F
I
A
R
S
G
D
A
S
W
------
L
N
------
T
D
G
-
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
-
G
G
R
-----
L
L
M
F
G
V
G
V
-----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
--
G
A
S
--
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
-------
A
H
F
H
N
-
G
-
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
--
V
P
E
T
K
G
K
T
L
E
E
L
E
A
-------
L
W
E
------------------
10
PsiBlast_PDB
63.98
27%
-132
- C1 -
4JA4
-
XYLE_ECOLI
A:
[17-479]
--------------------------------
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
----
E
S
L
N
T
V
F
V
A
------
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
---------
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
S
A
W
PELGF
T
S
I
N
P
---------------
D
N
T
-
V
P
-
V
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
-
C
V
N
Y
F
I
A
RS
G
D
A
S
W
------
L
N
------
T
D
G
-
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
--
L
Y
T
V
P
E
S
P
R
W
L
-
M
----
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
--------------
M
F
G
V
G
V
-----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
--------------L-
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
---
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
--
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
-
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
DKNS
W
-------------------
N
-
G
-
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
--
V
P
E
T
K
G
K
T
L
E
E
L
E
A
-------
L
W
E
------------------
6
PsiBlast_PDB
60.50
32%
-131
- C1 -
4LDS
-
?
A:
[45-427]
--------------------------------------------------------------------------------------------
G
I
V
V
S
S
M
L
I
G
A
I
V
G
A
G
S
SG
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
----------
L
I
L
A
------------------
A
-
S
T
-
N
L
-----
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
-
L
V
-------
N
Y
A
--------
F
A
------
D
I
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
-
V
G
--
I
Y
F
M
P
E
S
P
R
W
L
L
E
N
R
N
-
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
---
E
I
N
A
I
S
-
E
-----
S
T
W
T
V
I
K
S
P
W
L
-
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
--
G
L
G
--
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
-
I
M
A
I
-
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
--
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
-
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
-
I
V
S
L
F
F
-------
P
I
------
L
-------
S
D
A
L
S
T
E
-
W
V
F
L
I
F
A
F
I
--
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
------------------------------------
34
Fugue
51.64
13%
-119
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
FK
P
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
----------------------
E
Q
G
F
S
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
---------
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
----------
L
F
M
G
F
---------------
V
P
W
-
A
T
S
S
I
-----
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
-
L
L
-------
F
L
L
G
M
------
A
W
------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
-
F
A
--
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
---------------------
N
---
D
T
A
K
Q
I
-
F
M
Q
Y
V
L
-------------
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
--
V
K
H
--
F
A
L
--
D
K
S
S
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
-
L
V
T
I
A
T
I
V
Y
W
M
N
P
A
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
--
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
-
A
A
S
A
I
V
-------
G
Y
------
T
-------
V
D
F
F
G
-
W
-
D
G
G
F
M
V
M
I
G
--
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
------------------------
28
Fugue
49.16
13%
-114
- C1 -
3DAX
1
CP7A1_HUMAN
A:
[7-488]
--------
S
R
R
R
Q
T
G
E
P
P
-------
L
E
N
G
L
I
P
Y
L
G
C
A
L
Q
F
G
A
N
------
P
L
E
F
L
R
A
N
Q
R
K
H
--------------
G
H
V
F
T
C
K
L
M
G
K
Y
V
H
F
I
T
N
P
L
S
Y
H
K
V
L
C
H
G
---------
K
Y
F
D
W
K
K
F
H
F
A
T
S
A
K
A
F
G
H
R
S
----------
I
D
P
M
D
---------------
G
N
T
-
T
E
-
N
I
-----
N
D
T
F
I
K
T
L
Q
G
H
A
L
N
S
L
T
E
S
M
M
E
N
L
Q
R
I
M
R
A
W
V
T
E
G
M
Y
S
F
C
Y
R
V
M
F
E
A
G
Y
L
T
I
F
G
R
D
-------
L
T
R
R
D
------
T
Q
------
K
A
H
I
L
N
N
L
D
N
F
K
Q
F
D
K
V
F
P
A
-
L
V
A
G
L
P
I
H
M
F
R
T
A
H
N
A
R
E
K
L
A
E
S
L
R
H
E
N
L
Q
K
R
E
S
I
S
E
L
I
S
L
R
M
F
L
N
---
D
T
L
S
T
F
D
D
L
E
K
A
K
T
H
L
V
V
L
W
A
S
Q
A
N
T
I
P
A
T
F
W
S
L
F
Q
M
I
R
N
P
E
A
M
K
A
A
T
E
E
V
K
R
T
L
E
N
A
--
G
Q
K
--
V
S
L
--
E
---
G
N
P
I
C
L
S
Q
A
E
L
N
D
L
P
V
L
D
S
I
I
K
E
S
L
R
L
S
-
S
A
S
L
N
I
R
T
A
-
K
E
D
F
T
L
H
L
E
D
G
S
Y
N
I
R
K
D
D
I
I
A
L
Y
P
Q
L
M
H
L
DP
E
I
Y
P
D
P
L
T
F
K
Y
D
R
Y
L
D
E
N
-
G
K
T
K
T
T
F
Y
C
N
G
L
K
L
K
Y
Y
Y
M
-
P
F
G
S
G
A
-------
T
I
------
C
P------
G
R
L
F
A
-
I
-
H
E
I
K
Q
F
L
I
L
--
M
L
S
Y
F
E
L
E
L
I
E
G
Q
-------
A
K
C
P
P
L
D
Q
S
R
A
G
L
G
I
L
P
P
L
N
D
I
E
F
K
Y
K
F
K
H
H
H
-
14
HHSearch
44.54
13%
-118
- C1 -
1PW4
-
GLPT_ECOLI
A:
[64-449]
---------------------------------------------------------------------------------
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
---------
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
----------
L
F
M
G
F
---------------
V
P
W
A
T
S
-
S
I
-----
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
-
L
L
-------
F
L
L
G
-------
M
A
------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
--
F
A
M
M
R
D
T
P
Q
S
C
G
--
L
P
P
I
E
E
Y
K
N
--
D
---------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
-
W
Y
I
A
I
A
----
N
V
F
V
Y
-
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V
K-
H
F
A
L
D
K
S
S
--
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
-
A
T
I
V
-
Y
W
M
N
P
A
G
N
--
P
T
V
D
M
I
C
M
I
-
V
I
G
F
L
--
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
-
K
A
A
G
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
-------
G
Y
------
T
-------
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
--
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------
19
HHSearch
37.14
21%
-145
- C1 -
3WDO
-
?
A:
[51-188]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
V
-
I
A
A
L
----
S
-
D
S
I
---
W
G
I
I
L
G
R
A
-
L
Q
G
-
S
--
G
-
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
-
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
-------
P
I
------
I
-------
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
--
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
15
HHSearch
34.11
20%
-123
- C1 -
3WDO
-
?
A:
[47-189]
---------------------------------------------------------------------------------
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
---------
S
D
R
I
G
R
K
P
L
I
V
G
G
L
A
V
F
A
A
G
S
----------
V
I
A
A
L
---------------
S
----
D
-
S
I
-----
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
-
V
L
-------
G
P
I
--------
I
T
------
H
K
L
G
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
--
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
---
H
M
L
L
M
S
-
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
-
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
--
F
V
F
--
C
V
G
--
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
-
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
--
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
-
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
-
S
L
R
I
E
I
-------
P
A
------
D
-------
I
A
A
N
E
-
A
-
L
K
V
R
L
L
E
T
E
--
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-----------------
16
HHSearch
33.94
21%
-113
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[29-173]
------------------------------
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
F
T
L
T
------------------
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
---------
M
K
K
L
S
Y
K
A
G
I
I
T
G
L
F
L
Y
A
L
G
A
----------
A
L
F
W
P
---------------
A
A
E
-
I
M
-
N
Y
-----
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
-
V
F
-------
G
Q
S
L
I
------
L
S
------
N
V
P
H
Q
S
Q
D
V
L
D
K
M
S
P
E
Q
L
S
A
-
Y
K
--
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
---
Q
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
-
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
F
A
A
N
--
Y
L
T
--
G
T
M
--
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
-
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
--
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
-
E
L
I
P
A
L
-------
C
F
------
A
-------
V
I
F
I
F
-
A
-
R
F
R
S
Q
T
----------------------------------------------------------