@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GTR3_HUMAN: (2015-12-08 )
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
Atome Classification :
(20 SA)
.........10....-....20........30........40........50........60........70........80........90......---..100....-----...110-------------...----------...-...120.......130..----.....140.......150.......160.......170.......--------180------....------...190.......-200.......210.......220.......230.......240..--.....250.......260.......270.......280.......290.....--..--300....--.--....310.......320.......330.......340.......350.......360.......370.......380.......390.......400...-....410..-.....420-------.-------......-430........440.......450.......460.......470....---...480.......490....------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGTQKVTP
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
GYNTGVIN
A
P
E
K
I
I
K
E
F
I
N
K
T
LTDKGNA
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
VGGMI
G
S
F
S
V
G
L
F
V
N
R
FGRRN
S
M
L
I
V
---
N
L
L
A
VTG
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
IGEI
S
P
T
A
L
R
G
A
FG
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
LG--------S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S-AALPFCPES
P
R
F
L
L
I
NRKEE
E
N
A
K
Q
I
L
Q
R
LWGT
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
RMSQEK
Q
V
T
V
L
E
L
F
R
V
SSYRQ
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
LSG
I
N
A
V
F
Y
YSTGIFK--DA--G--VQE
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
RAGR
R
T
L
H
M
IGLG
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
KDNYNG
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
EIGPGP
I
P
W
F
I
V
A
E
L
F
SQGPR
P
A
A
M
A
V
A-GCSNW
T
S
N
F
-
L
V
G
L
LFP
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
FKVPETRGR
T
F
E
D
I
T
R
A
FEGQAHGADRSG---KDG
V
M
EMNSIEPAKETTTNV------------------
2
PsiBlast_PDB
97.14
99%
-130
- C1 -
4ZWB
1
?
A:
[25-492]
--
T
Q
K
V
T
P
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
--
G
--
V
Q
E
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------------------------
1
PsiBlast_PDB
96.74
99%
-129
- C1 -
4ZW9
4
?
A:
[23-492]
M
G
T
Q
K
V
T
P
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
--
G
--
V
Q
E
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------------------------
3
PsiBlast_PDB
96.50
99%
-134
- C1 -
4ZWC
3
?
A:
[25-492]
--
T
Q
K
V
T
P
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
--
G
--
V
Q
E
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------------------------
15
PsiBlast_CBE
96.11
99%
-134
- C1 -
4ZWC
2
?
B:
[25-492]
--
T
Q
K
V
T
P
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
T
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
--
G
--
V
Q
E
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
-----------------------------------------------
16
PsiBlast_CBE
95.19
99%
-134
- C1 -
5C65
7
?
B:
[6-469]
-----
V
T
P
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
L
T
D
K
--
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
R
M
S
---
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
-------
E
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
----
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
------------------------------------------------
4
PsiBlast_PDB
94.58
99%
-133
- C1 -
5C65
8
?
A:
[5-469]
----
K
V
T
P
A
L
I
F
A
I
T
-
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
Q
K
T
L
T
D
K
G
N
A
P
P
S
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
---
N
L
L
A
V
T
G
G
C
-----
F
M
G
L
---------------
C
K
V
----------
A
K
S
-
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
----
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
--------
S
E
E
------
L
W
P
L
------
L
L
G
F
T
I
L
P
A
I
L
Q
S
-
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
K
E
E
E
N
A
K
Q
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
--
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
--
D
A
--------
P
--
I
--
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
----
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
-
G
C
S
N
W
T
S
N
F
-
L
V
G
L
L
F
P
S
-------
A
-------
A
H
Y
L
G
A
-
Y
-
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
------------------------------------------------
5
PsiBlast_PDB
86.25
65%
-138
- C1 -
4PYP
1
GTR1_HUMAN
A:
[9-455]
------
T
G
R
L
M
L
A
V
G
-
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
T
Q
T
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
---
N
L
L
A
F
V
S
A
V
-----
L
M
G
F
---------------
S
K
L
----------
G
K
S
-
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
----
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
G
--------
N
K
D
------
L
W
P
L
------
L
L
S
I
I
F
I
P
A
L
L
Q
C
-
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
--
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
--
K
A
--
G
--
V
Q
Q
P
--
V
--
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
-
G
F
S
N
W
T
S
N
F
-
I
V
G
M
C
F
Q
Y
-------
V
-------
E
Q
L
C
G
P
-
Y
-
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
----------------------------------------------------------------
28
Fugue
70.15
29%
-114
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
----
Y
N
S
S
Y
I
F
S
I
T
L
-
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
------
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
-----
G
S
A
W
PELGFTSINPDNTVP
V
Y
L
----------
A
G
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
--------
G
D
A
S
W
L
N
T
D
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
S
R
G
K
-
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
--
S
L
D
H
G
R
K
T
G
G
------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
--
T
L
GA
S
--
T
D
I
A
--
L
--
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
----
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
-------
A
H
F
H
N
G
-
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------
10
PsiBlast_PDB
70.00
29%
-111
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
----
Y
-
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
----
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
--
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WP
E
L
G
F
---------------
T
S
I
NPDNTVPVYL
A
G
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
--
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
----
L
L
M
F
G
V
G
V
----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
--
T
L
--
G
--
A
S
T
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
-------
A
H
F
H
N
G
-
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------
8
PsiBlast_PDB
69.65
29%
-116
- C1 -
4GBY
5
XYLE_ECOLI
A:
[5-479]
----
Y
-
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
----
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
--
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WP
E
L
G
F
---------------
T
S
I
NPDNTVPVYL
A
G
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
--
V
Y
C
V
N
Y
F
I
A
R
SGD
A
S
W
L
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
----
L
L
M
F
G
V
G
V
----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
--
T
L
--
G
--
A
S
T
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
-------
A
H
F
H
N
G
-
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------
9
PsiBlast_PDB
69.45
29%
-116
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[5-479]
----
Y
-
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
----
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
--
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
G
F
---------------
T
S
I
NPDNTVPVYL
A
G
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
--
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
----
L
L
M
F
G
V
G
V
----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
--
T
L
--
G
--
A
S
T
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
V
-------
A
H
F
H
N
G
-
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------
7
PsiBlast_PDB
68.67
29%
-135
- C1 -
4JA4
-
XYLE_ECOLI
A:
[9-479]
---------
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
----
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
--
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
P
E
L
G
F
---------------
T
S
I
N
P
D
N
T
V
PVYL
A
G
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
--
V
Y
C
V
N
Y
F
I
A
RSGD
A
S
W
L
N
T
D
------
G
W
R
Y
------
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-----
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
------------
M
F
G
V
G
V
----
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------------L-
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
--
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
I
--
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
DKNSW-------------
N
G
-
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
---------------------------------------------------
29
Fugue
63.75
30%
-134
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
-------
S
Y
I
F
S
I
T
L
-
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
---
V
A
P
Q
N
---
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
-----
G
S
A
W
PELGFTSINPDNTVP
V
Y
L
----------
A
G
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
----
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
--------
G
D
A
------
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
-
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-------------------
T
L
A
T
Q
A
V
Q
E
I
K
H
--
S
L
D
R
L
-------------
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
--
T
L
--
G
--
A
S
T
D
--
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
----
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
-------
M
DKN
S
W
L
V
A
H
F
H
N
G
-
F
-
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
-----------------------------------------------------------
6
PsiBlast_PDB
62.22
31%
-121
- C1 -
4LDS
-
?
A:
[53-427]
------------------------------------------------------------------------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
---
A
I
V
F
I
I
G
A
L
-----
I
L
A
------------------
A
----------
S
T
N
-
L
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
----
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
F
--
A
--------
D
I
E
------
G
W
R
W
------
M
L
G
L
A
V
V
P
S
V
I
L
L
-
V
G
I
Y
F
M
P
E
S
P
R
W
L
L
E
N
R
N
E
E
A
-
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
--
I
N
A
--
I
S
E
S
T
W
T
V
I
---
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
--
K
A
--
G
--
L
G
E
A
A
S
I
--
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
-
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
-
A
L
V
L
N
I
G
T
L
-
I
V
S
L
F
F
P
I
-------
L
-------
S
D
A
L
S
T
E
W
-
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
--------------------------------------------------------------
37
Fugue
56.06
17%
-114
- C1 -
3WDO
-
?
A:
[1-453]
--
D
Y
K
M
T
P
------------
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
G
A
S
--
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
-----
I
A
A
L
----------------------------
S
D
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
--
G
A
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
-
P
I
I
T
H
--------
K
L
G
------
L
H
A
L
------
F
W
M
I
A
I
L
A
T
T
G
I
A
-
L
T
I
W
V
V
P
N
S
S
T
H
V
L
--------------------------------------
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
--
L
M
S
T
F
V
A
L
P
G
Q
L
A
--
D
A
--
G
--
F
P
A
A
--
E
--
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
----
F
V
F
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
-
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
W
-------
I
-------
D
G
M
F
D
G
-
Q
-
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL
17
HHSearch
46.45
14%
-119
- C1 -
1PW4
-
GLPT_ECOLI
A:
[63-449]
-------------------------------------------------------------
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
-----
F
M
G
F
---------------
V
P
W
A
---------
T
S
S
-
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
-
A
--------
W
F
N
------
D
W
H
A
------
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
-
E
E
-
Y
K
N
---
D
------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
----
I
A
I
A
N
V
F
V
Y
L
-
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
--
E
V
K-
H
FA
L
D
K
S
--
S
--
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
-
P
-
A
G
N
P
T
V
D
M
--
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
-------
T
-------
V
D
F
F
G
W
-
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------
21
HHSearch
42.28
14%
-102
- C1 -
2CFQ
-
LACY_ECOLI
A:
[43-378]
-------------------------------------------------------------
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
-----
I
F
I
F
----------------------------
G
P
L
L
Q
Y
N
I
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
N
F
E
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
-----------
T
I
------
N
N
Q
F
------
V
F
W
L
G
S
G
C
A
L
I
L
A
-
V
L
L
F
F
A
K
T
D
A
P
S
S
--
A
T
V
A
N
A
---
V
------
G
-----
A
------
N
--
H
----
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
-
F
A
N
F
F
T
S
F
F
A
T
G
E
Q
--
G
--
T
R
V
F
--
G
--
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
G
T
I
M
S
V
R
I
I
G
S
S
F
A
T
-------
S
A
L
E
V
V
--
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
-------
M
-------
Y
E
S
I
G
F
-
Q
-
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-------------------------------------------------
18
HHSearch
37.67
16%
-143
- C1 -
3WDO
-
?
A:
[46-189]
-------------------------------------------------------------
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
-----
I
A
A
L
---------------
S
D
-------------
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
----------
H
K
L
------
G
L
H
A
------
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
--
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
--
Q
V
--
F
--
V
F
C
V
--
G
--
L
I
V
V
A
E
I
V
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
-
T
M
K
E
P
P
Y
V
S
-
S
L
R
I
E
I
P
A
-------
D
-------
I
A
A
N
E
A
-
L
-
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-------------------------------------------
19
HHSearch
37.35
15%
-139
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[61-174]
-------------------------------------------------------------
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
-----
L
F
W
P
---------------
A
A
E
----------
I
M
N
-
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
S
--------
N
V
P
------
H
Q
S
Q
------
D
V
L
D
K
M
S
P
E
Q
L
S
A
-
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
--
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I
P
G
M
T
A
G
F
A
--
A
N
--
Y
--
L
T
G
T
--
M
--
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
G
G
H
V
G
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
G
Q
D
T
K
Y
G
S
S
F
I
V
M
T
I
I
G
G
G
I
V
T
P
V
M
G
F
V
S
-
D
A
A
G
N
I
P
T
A
-
E
L
I
P
A
L
C
F
-------
A
-------
V
I
F
I
F
A
-
R
-
F
R
S
Q
T
----------------------------------------------------------------------------------
20
HHSearch
35.25
16%
-122
- C1 -
2GFP
-
EMRD_ECOLI
A:
[43-170]
-------------------------------------------------------------
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
-----
V
A
V
T
---------------
T
-------------
S
S
-
L
T
V
L
I
A
A
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
----------
T
M
W
------
N
W
R
A
------
C
Y
L
F
L
L
V
L
C
A
G
V
T
-
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
--
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
L
G
L
S
S
M
T
V
S
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
--
W
Q
--
S
--
V
I
C
C
--
L
--
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
P
F
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
-
L
--------------------------------------------------------------------------------------------------------------------------------