@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GHC1_HUMAN: (2015-12-08 )
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQA
Atome Classification :
(20 SA)
------.........10.......-.20........30........40----..--------...--------....50........60.-----....---...70.---.......80........90.----..-----..-.-----------.-----.100..--------..-----...-110.......120.----......130-..-.--..----..140.......150...----------....160.......170----..-......180.......190.......200....--------------...210.......220-----.......---.230.------......240..------.....-----250.--.--.....260......-----..270.......280....-...290...---....300.......310....-...320.-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MADKQIS
L
P
A
K
L
INGGI
A
-
G
L
I
G
V
T
C
V
F
P
I
D
L
A
K
T
R
L
QNQQ-----NG--------
Q
R
V
--------
Y
T
S
M
S
D
C
L
I
K
T
V
RSEG
Y
-----
F
G
M
Y---RG
A
A
V
N
---
L
T
L
V
T
P
E
K
A
I
K
L
A
A
N
D
F
F
R
H
----
Q
L
-----SK-D-----------G-----
Q
K
L
T
L
L
--------
K
E
-----
M
L
A
-GCGAG
T
C
Q
V
I
V
TT
P
----
M
E
M
L
K
I
Q
L
Q-DA-
G
--
R
I
----
A
A
Q
R
K
I
LAAQGQLSAQGG----------AQPSVEAPAAPR
P
T
A
T
-----
Q
L
-
T
R
D
L
L
R
SR
G
I
A
G
L
Y
K
G
L
G
A
T
L
L
R
DVP
F
S
V
V
Y
F
P
--------------
L
F
A
N
L
N
Q
LGRPASEE------KSP
F
Y
V
S
---
F
L
A
G
C
------VAGS
A
A
A
V
AV
N
------
P
C
D
V
V
-----
K
T
R
L
--
Q
--
S
L
Q
RGV-NE
D
T
Y
S
G
-----
I
L
D
C
A
R
K
I
L
RHEG
P
S
A
F
L
K
-
G
A
Y
C
R
A
L
V
I
---
A
P
L
F
G
I
A
Q
V
V
Y
F
L
G
I
A
E
S
L
L
G
-
L
LQDPQA-------
2
PsiBlast_PDB
85.91
24%
-54
- C3 -
2C3E
4
ADT1_BOVIN
A:
[1-278]
-------
S
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
-----
A
S
--------
K
Q
I
SAEKQ---
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
-----
L
S
F
W
---
R
G
N
L
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
LG
G
V
-----
D
R
-
H
-----------
K
-----
Q
F
W
R
Y
F
--------
A
G
-----
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
----
L
D
F
A
R
T
R
L
A
A
D
V
-
G
--
K
G
----
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
----------------------------------------
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------------
V
Y
D
T
A
K
--
G
M
L
P
D
P
K
------
N
V
H
I
I
V
S
---
W
M
I
A
Q
------
T
V
T
A
V
A
G
L
V
S
Y
------
P
F
D
T
V
-----
R
R
R
M
M
M
Q
--
S
G
R
K
G
A
--
D
I
M
Y
T
G
-----
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
-
G
A
W
S
N
V
L
R
G
---
M
G
G
A
F
V
L
V
L
Y
D
E
I
-----------------------
3
PsiBlast_PDB
85.54
25%
-58
- C3 -
4C9J
4
ADT3_YEAST
A:
[25-302]
-----------
T
N
F
A
I
N
F
L
M
G
G
V
S
-
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
Q
N
Q
D
-----
E
M
I
K
Q
GTL--
D
K
K
--------
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
-----
I
S
F
W
---
R
G
N
T
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
----
M
F
GFK--
K
E
-
E
-----------
G
-----
Y
G
K
W
F
A
--------
G
N
-----
L
A
S
-
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
----
L
D
F
---------------------
A
R
T
R
L
A
A
D
A
K
S
---------------
A
R
Q
F
--------
N
G
L
T
-----
D
V
-
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------------
M
F
D
S
L
K
-------------------------
F
L
L
G
W
------
V
V
T
T
G
A
S
T
C
S
Y
------
P
L
D
T
V
-----
R
R
R
M
------
M
M
T
S
G
-
Q
A
V
K
Y
N
G
-----
A
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
-
G
--
C
G
A
N
I
L
---
R
S
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
-
K
K
F
-----------
4
PsiBlast_PDB
84.16
25%
-62
- C3 -
4C9Q
5
ADT3_YEAST
A:
[23-302]
---------
Q
E
T
N
F
A
I
N
F
L
M
G
G
V
S
-
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
L
I
Q
N
Q
D
-----
E
M
I
K
Q
GTL--
D
K
K
--------
Y
S
G
I
V
D
C
F
K
R
T
A
K
Q
E
G
L
-----
I
S
F
W
---
R
G
N
T
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
----
M
F
GFK--
K
E
-------------
G
-----
Y
G
K
W
F
A
--------
G
N
-----
L
A
S
-
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
----
L
D
F
---------------------
A
R
T
R
L
A
A
D
A
K
S
---------------
A
R
Q
F
--------
N
G
L
T
-----
D
V
-
Y
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------------
M
F
D
S
L
K
P
L
----------------
F
L
A
S
---
F
L
L
G
W
------
V
V
T
T
G
A
S
T
C
S
Y
------
P
L
D
T
V
-----
R
R
R
M
------
M
M
T
S
G
-
Q
A
V
K
Y
N
G
-----
A
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
-
G
--
C
G
A
N
I
L
---
R
S
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
-
K
-------------
20
Fugue
80.81
22%
-58
* C3 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
--------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
ASKQI
S
A
--------
E
K
Q
--------
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
-----
L
S
F
W
---
R
G
N
L
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
----
I
F
L
GGVD
R
H
-
K
-----------
Q
-----
F
W
R
Y
F
A
--------
G
N
-----
L
A
S
-
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
----
L
D
F
A
R
T
R
L
A
-
A
----------------------------------------
D
V
G
K
G
A
A
Q
R
E
F
T
G
L
G
-----
N
C
-
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------------
V
Y
D
T
A
K
G
M
L
P
--
D
P
K
------
N
V
H
I
I
V
S
---
W
M
I
A
Q
------
T
V
T
A
V
A
G
L
V
S
Y
------
P
F
D
T
V
-----
R
R
R
M
--
M
M
-
Q
S
G
R
K
G
-
A
D
I
M
Y
T
G
-----
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
-
G
------
A
W
---
S
N
V
L
R
G
M
G
G
A
F
V
L
V
L
Y
D
E
I
-----------------
11
HHSearch
80.44
22%
-51
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
--------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
-----
A
S
KQISA---
E
K
Q
--------
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
-----
L
S
F
W
---
R
G
N
L
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
----
I
F
-----
L
G
-
G
-----------
V
DRHKQ
F
W
R
Y
F
A
--------
G
N
-----
L
A
S
-
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
----
L
D
F
A
R
T
R
L
A
-
A
D
-
V
--
G
K
----
G
A
A
Q
---------------------------------
R
E
F
T
G
L
G
-----
N
C
-
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------------
V
Y
D
T
A
K
G
M
L
P
D
P
K
--------
N
V
H
I
I
V
S
---
W
M
I
A
Q
------
T
V
T
A
V
A
G
L
V
S
Y
------
P
F
D
T
V
-----
R
R
R
M
--
M
--
M
Q
S
G
R
K
G
A
D
I
M
Y
T
G
-----
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
-
G
A
W
S
N
V
L
R
G
---
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
----------------------
28
Fugue
79.71
18%
-50
- C1 -
1ZY7
1
RED1_HUMAN
A:
[8-402]
SR
Q
P
I
P
S
E
G
L
Q
L
H
L
P
Q
V
L
A
D
A
V
S
R
-
L
V
L
G
K
F
G
D
L
T
D
N
F
S
S
P
H
A
R
R
K
V
-----
L
A
--------
G
V
V
--------
M
T
T
G
T
D
V
K
D
A
K
V
I
S
V
S
T
G
T
K
C
I
N
G
E
Y
MSD
R
G
L
A
L
N
DCH
A
E
I
I
S
R
R
S
L
L
R
F
L
Y
T
Q
L
E
L
Y
----
L
N
-----
N
K
-
D
-----------
D
-----
Q
K
R
S
I
F
--------
Q
K
SERG
G
F
R
L
-
K
E
N
V
Q
F
H
L
Y
I
S
T
S
P
----
C
G
D
A
R
I
-
F
K
-
A
R
-
G
--
Q
L
------
R
T
K
I
E
S
G
E
G
T
I
P
V
R
S
N
----------
A
S
I
Q
T
W
D
G
V
L
Q
G
E
R
L
L
-----
T
M
S
C
S
D
K
I
A
R
W
N
V
V
G
I
Q
G
S
L
L
S
I
F
V
E
P
I
Y
F
S
S
I
I
L
G
--------------
S
L
Y
H
G
D
H
L
S
R
A
M
Y
Q
R
ISNIED
L
P
P
L
Y
T
L
NK
P
L
L
S
G
I
S
N
A
E
A
R
Q
P
G
K
A
P
N
F
S
V
N
W
T
VGDS
A
I
E
V
I
NATTG
K
D
E
L
--
G
--
R
A
S
R
L
C
-
K
H
A
L
Y
C
R
-----
W
M
R
V
H
G
K
V
P
S
H
L
L
R
S
K
I
T
K
P
N
V
Y
H
E
S
K
L
A
---
A
K
E
Y
Q
A
A
K
A
R
L
F
T
A
F
I
K
A
G
L
G
A
W
V
E
K
P
T
E
QDQFSLT
1
PsiBlast_PDB
77.97
24%
-51
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-278]
--------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
-
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
-----
A
S
--------
K
Q
I
SAEKQ---
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
-----
L
S
F
W
---
R
G
N
L
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
V
-----
D
R
-
H
-----------
K
-----
Q
F
W
R
Y
F
--------
A
G
-----
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
----
L
D
F
A
R
T
R
L
A
A
D
V
-
G
--
K
G
----
A
A
Q
R
E
F
T
G
L
G
N
C
I
T
----------------------------------------
K
I
F
K
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
--------------
V
Y
D
T
A
K
--
G
M
L
P
D
P
K
------
N
V
H
I
I
V
S
---
W
M
I
A
Q
------
T
V
T
A
V
A
G
L
V
S
Y
------
P
F
D
T
V
-----
R
R
R
M
M
M
Q
--
S
G
R
K
G
A
--
D
I
M
Y
T
G
-----
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
-
G
A
W
S
N
V
L
R
G
---
M
G
G
A
F
V
L
V
L
Y
D
E
I
-----------------------
10
HHSearch
77.71
24%
-60
- C3 -
2LCK
-
UCP2_MOUSE
A:
[14-303]
--------------
T
V
K
F
L
G
A
G
T
A
-
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
V
R
L
Q
I
Q
G
-----
E
S
QG
L
V
R
T
A
A
S
A
Q
--------
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
E
G
P
-----
R
S
L
Y
---
N
G
L
V
A
G
---
L
Q
R
Q
M
S
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
----
F
Y
-----
T
K
-
G
-----------
S
-----
E
H
A
G
I
G
--------
S
R
-----
L
L
A
-
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
----
T
D
V
V
K
V
R
F
Q
-
A
Q
-
A
--
R
A
----
G
G
G
----------------------------------
R
R
Y
Q
S
T
V
-----
E
A
-
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
V
--------------
T
Y
D
L
I
K
D
T
L
L
K
A
N
L
M
------
T
D
D
L
P
C
H
---
F
T
S
A
F
------
G
A
G
F
C
T
T
V
I
A
S
------
P
V
D
V
V
-----
K
T
R
Y
--
M
--
N
S
A
L
G
-----
Q
Y
H
S
-----
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
-
G
F
M
P
S
F
L
R
L
---
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
-
Y
Q
S
R
E
A
P
-------
5
PsiBlast_PDB
75.42
25%
-48
- C3 -
4C9G
5
ADT2_YEAST
A:
[27-287]
-----------------
F
L
M
G
G
V
S
-
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
L
L
I
Q
N
Q
D
-----
E
M
L
K
Q
GTL--
D
R
K
--------
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
-----
I
S
F
W
---
R
G
N
T
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
A
----
M
F
GFK--
K
E
-
E
-----------
G
-----
Y
A
K
W
F
A
--------
G
N
-----
L
A
S
-
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
----
L
D
Y
---------------------
A
R
T
R
L
A
A
D
S
------------------
R
Q
F
N
G
L
I
D
V
Y
K
K
T
--------------
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------------
M
Y
D
S
L
--------------------
L
A
S
---
F
L
L
G
W
------
V
V
T
T
G
A
S
T
C
S
Y
------
P
L
D
T
V
-----
R
R
R
M
------
M
M
T
S
G
-
Q
A
V
K
Y
D
G
-----
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
-
G
C
G
A
N
I
L
R
G
---
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
----------------------
6
PsiBlast_PDB
73.47
25%
-47
- C3 -
4C9H
5
ADT2_YEAST
A:
[27-287]
-----------------
F
L
M
G
G
V
S
-
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
L
L
I
Q
N
Q
D
-----
E
M
L
K
Q
GTL--
D
R
K
--------
Y
A
G
I
L
D
C
F
K
R
T
A
T
Q
E
G
V
-----
I
S
F
W
---
R
G
N
T
A
N
---
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
A
----
M
F
G
F
K
--
K
E
-
E
-----------
G
-----
Y
A
K
W
F
A
--------
G
N
-----
L
A
S
-
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
----
L
D
Y
---------------------
A
R
T
R
L
A
A
D
S
-----------------
A
R
Q
F
N
G
L
I
D
V
Y
K
K
T
--------------
L
K
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
--------------
M
Y
D
S
L
K
-------------------
L
A
S
---
F
L
L
G
W
------
V
V
T
T
G
A
S
T
C
S
Y
------
P
L
D
T
V
-----
R
R
R
M
------
M
M
T
S
G
-
Q
A
V
K
Y
D
G
-----
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
-
G
C
G
A
N
I
L
R
G
---
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
-
F
K
------------
7
PsiBlast_PDB
71.90
25%
-47
- C3 -
2LCK
-
UCP2_MOUSE
A:
[13-272]
-------------
M
T
V
K
F
L
G
A
G
T
A
-
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
V
R
L
Q
I
Q
G
-----
E
S
--------
Q
G
L
V
R
T
A
ASAQ
Y
R
G
V
L
G
T
I
L
T
M
V
R
T
E
G
P
-----
R
S
L
Y
---
N
G
L
V
A
G
---
L
Q
R
Q
M
S
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
----
F
Y
-----
T
K
-
G
-----------
S
-----
E
H
A
G
I
G
--------
S
R
-----
L
L
A
-
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
----
T
D
V
V
K
V
R
F
Q
-
A
Q
-
A
--
R
A
----
G
G
G
R
R
Y
-----------------------
Q
S
T
V
E
A
-----------------
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
N
C
A
E
L
V
--------------
T
Y
D
L
I
K
D
T
L
L
K
A
N
L
M
------
T
D
D
L
P
C
H
---
F
T
S
A
F
------
G
A
G
F
C
T
T
V
I
A
S
------
P
V
D
V
V
-----
K
T
R
Y
--
M
--
N
S
A
L
G
-----
Q
Y
H
S
-----
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
-
G
F
M
P
S
F
L
R
L
---
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
-
Y
Q
S
R
E
A
P
-------
22
Fugue
68.70
17%
-68
- C3 -
2Y23
4
A:
[6-312]
--------
T
K
E
V
-----
V
V
N
V
D
D
D
-
G
V
I
S
L
N
F
E
C
D
K
M
T
P
K
S
E
F
S
W
S
K
-----
D
--------------------
Y
V
S
T
E
D
S
P
R
L
E
V
E
S
K
G
---------------
N
K
T
K
---
M
T
F
----
K
D
L
G
M
D
D
L
G
I
Y
S
C
----
D
V
-----
T
D
T
D
-----------
G
-----
I
A
S
S
Y
L
I
D
------
E
E
-----
E
L
K
-
R
L
L
A
L
S
H
E
H
K
F
P
T
V
PV--
K
S
E
L
A
V
E
I
L
-
E
K
-
G
Q
V
R
F
----
W
M
Q
A
E
K
L
S
G
N
A
K
V
N
Y
I
F
N
----------
E
K
E
I
F
E
G
P
K
Y
K
M
H
I
D
R
NTG
I
I
E
M
-
F
M
E
K
L
Q
D
E
D
E
G
T
Y
T
F
Q
L
Q
D
G
K
A
T
N
H
S
T
V
V
L
V
G
D
--------------
V
F
K
K
L
Q
K
E
A
E
F
Q
R
Q
E
W
I
R
K
--
Q
G
P
H
F
V
E
---
Y
L
S
W
E
------
V
T
G
E
C
----------------------
N
V
L
L
--
K
--
C
K
V
A
N
I
-
K
K
E
T
H
I
V
-----
W
Y
K
D
E
R
E
I
S
V
D
E
------
K
-
H
G
I
C
T
L
L
I
T
EFS
K
K
D
A
G
I
Y
E
V
I
L
K
D
D
R
G
K
D
K
S
R
-
L
K
L
V
D
E
A
-------
25
Fugue
61.85
12%
-35
* C4 *
1H74
2
KHSE_METJA
A:
[1-296]
-------
M
K
V
R
V
K
A
P
C
T
S
A
N
L
G
V
G
F
D
V
F
G
L
C
L
K
E
P
Y
D
V
I
E
V
E
A
I
D
D
K
-----
E
-----------------------------
I
I
I
E
V
D
D
K
-----------------
N
---
I
P
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
----
F
N
-----
I
G
-
K
-----------
G
-----
V
K
I
T
I
K
--------
K
G
-----
V
K
A
-
G
S
G
L
G
S
S
A
A
S
S
A
G
T
----
A
Y
A
I
N
-
E
L
F
-
K
L
-
N
--
L
D
----
K
L
K
L
V
D
Y
A
S
Y
G
E
L
A
S
S
G
A
----------
K
H
A
D
N
V
A
P
A
I
F
G
G
F
T
M
-----
V
T
-
N
Y
E
P
L
E
V
L
H
I
---------
P
I
D
F
K
L
D
I
L
I
A
I
P
N
--------------
I
S
I
N
T
K
E
A
R
E
I
L
P
K
A
------
V
G
L
K
D
L
V
---
N
N
V
G
K
------
A
C
G
M
V
Y
A
L
Y
N
K
------
D
K
S
L
F
-----
G
R
Y
M
--
M
SD
K
V
I
E
P
V
-
R
G
K
L
I
P
N
------
Y
F
K
I
K
E
E
V
K
D
K
V
Y
G
I
T
I
S
-
G
S
G
P
S
I
I
A
F
---
P
K
E
E
F
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
T
I
-
R
T
E
V
G
K
G
VEVV---
27
Fugue
60.01
12%
-35
- C4 -
1FWK
1
KHSE_METJA
A:
[1-296]
-------
M
K
V
R
V
K
A
P
C
T
S
A
N
L
G
V
G
F
D
V
F
G
L
C
L
K
E
P
Y
D
V
I
E
V
E
A
I
D
D
K
-----
E
-----------------------------
I
I
I
E
V
D
D
K
-----------------
N
---
I
P
T
D
P
D
K
N
V
A
G
I
V
A
K
K
M
I
D
D
----
F
N
-----
I
G
-
K
-----------
G
-----
V
K
I
T
I
K
--------
K
G
-----
V
K
A
-
G
S
G
L
G
S
S
A
A
S
S
A
G
T
----
A
Y
A
I
N
-
E
L
F
-
K
L
-
N
--
L
D
----
K
L
K
L
V
D
Y
A
S
Y
G
E
L
A
S
S
G
A
----------
K
H
A
D
N
V
A
P
A
I
F
G
G
F
T
M
-----
V
T
-
N
Y
E
P
L
E
V
L
H
I
---------
P
I
D
F
K
L
D
I
L
I
A
I
P
N
--------------
I
S
I
N
T
K
E
A
R
E
I
L
P
K
A
------
V
G
L
K
D
L
V
---
N
N
V
G
K
------
A
C
G
M
V
Y
A
L
Y
N
K
------
D
K
S
L
F
-----
G
R
Y
M
--
M
SD
K
V
I
E
P
V
-
R
G
K
L
I
P
N
-----
Y
F
K
I
K
E
E
-
V
K
D
K
V
Y
G
I
T
I
S
-
G
S
G
P
S
I
I
A
F
---
P
K
E
E
F
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
T
I
-
R
T
E
V
G
K
G
VEVV---
21
Fugue
59.28
12%
-48
- C4 -
3SKV
2
?
A:
[28-384]
------
R
A
R
A
D
R
S
V
S
P
T
D
P
A
L
T
Y
R
-
G
A
V
S
L
Q
D
R
D
G
-
W
L
A
P
W
R
A
P
H
E
D
-----
A
Y
--------
L
Y
F
--------
P
K
G
S
V
G
R
L
A
Q
T
S
G
V
R
L
H
-----
L
R
T
D
---
S
P
W
L
A
V
---
R
Y
E
A
V
G
P
K
P
K
P
G
E
P
Q
E
P
A
L
L
----
D
V
-----
L
V
-
D
-----------
G
-----
E
L
A
R
T
V
E
L
K
L
DAD
A
E
L
-----
H
V
D
-
G
L
P
A
G
D
K
L
V
E
L
W
L
P
TL
L
Q
F
R
L
A
E
V
R
L
E
-
A
G
-
A
--
T
L
E
K
DT
S
S
K
P
H
W
I
H
Y
G
D
S
I
C
H
G
R
G
----------
A
A
S
P
S
R
T
W
L
A
L
A
A
R
A
E
-----
G
L
-
D
L
Q
S
L
S
F
A
A
D
G
S
H
L
Q
P
M
F
A
R
L
I
R
D
L
P
A
D
L
I
S
L
R
V
G
T
S
N
F
M
D
GDGFVD
F
P
A
N
L
V
G
F
V
Q
I
I
R
E
R
------
H
P
L
T
P
I
V
---
L
G
S
S
V
------
Y
S
P
F
W
D
E
L
P
A
D
------
D
K
P
T
V
-----
A
D
Y
R
--
E
--
Q
V
V
K
V
A
-
E
L
L
R
K
H
G
DQN
V
H
Y
L
D
-
G
M
R
V
W
G
P
E
R
G
M
E
L
Y
L
-
E
K
P
D
K
Y
P
T
H
---
P
N
A
V
G
H
E
I
F
A
E
--
S
S
R
R
E
M
A
A
-
L
G
V
L
P
V
R
-------
13
HHSearch
57.05
19%
-41
- C3 -
1OKC
9
ADT1_BOVIN
A:
[110-293]
-----------
R
Y
F
A
G
N
L
A
S
G
G
A
A
-
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
-----
G
K
GAA-----
Q
R
E
--------
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
-----
R
G
L
Y
---
Q
G
F
N
V
S
---
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
----
M
L
-----
P
D
-
P
-----------
K
------
N
V
H
I
I
--------
V
S
-----
W
M
I
-
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
----
F
D
T
V
R
R
R
M
M
-
M
Q
-
S
--
G
R
----
K
G
A
---------------------------------
D
I
M
Y
T
G
T
V
-----
D
C
-
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
M
G
-
G
A
F
V
L
V
--------------
L
Y
D
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
54.25
24%
-41
- C3 -
2LCK
-
UCP2_MOUSE
A:
[114-302]
-----------
A
G
I
G
S
R
L
L
A
G
S
T
T
-
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
-----
R
A
GG------
G
R
R
--------
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
-----
R
G
L
W
---
K
G
T
S
P
N
---
V
A
R
N
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
----
T
L
-----
L
K
-
A
N----------
L
-----
M
T
D
D
L
P
--------
C
H
-----
F
T
S
-
A
F
G
A
G
F
C
T
T
V
I
A
S
P
----
V
D
V
V
K
T
R
Y
M
-
N
S
-
A
--
L
------------------------------------------
G
Q
Y
H
S
A
G
-----
H
C
-
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
G
S
W
N
V
V
M
F
V
--------------
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
------
R
E
A
P
F
-------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
53.23
13%
-53
- C2 -
3SKQ
-
MDM38_YEAST
A:
[23-249]
------
K
L
I
E
I
R
K
K
T
S
E
F
L
H
E
T
L
E
-
E
S
------------
N
L
I
T
Y
N
T
I
-----
E
N
--------
A
E
K
--------
K
Q
K
F
L
N
F
F
R
K
L
Y
S
A
K
E
G
-----
K
I
---------------
M
T
F
Q
H
D
E
I
S
A
I
A
Q
--
M
F
K
N
----
D
S
-----
V
L
-
D
-----------
N
-----
L
S
R
P
Q
L
--------
A
A
-----
M
S
K
-
F
M
S
L
R
P
-----
F
G
N
----
D
N
M
L
R
Y
Q
I
R
-
S
K
L
K
--
D
I
----
M
N
D
D
K
T
I
D
Y
E
G
--------------------------
V
E
S
L
S
Q
E
-----
E
L
-
Y
Q
A
C
V
S
-
R
G
M
----
K
A
Y
G
V
S
----------
K
E
D
--------------
L
V
D
N
L
K
V
W
L
E
L
R
L
R
Q
------
K
I
P
S
V
L
M
---
V
L
S
S
T
------
F
T
-----
F
G
G
L
------
P
K
E
N
Y
-----
S
K
A
F
--
S
--
P
L
A
E
K
K
-
E
T
K
S
------------------------------------------
K
Y
D
D
L
L
D
L
Y
Y
D
G
I
L
Q
V
L
S
S
-
I
P
D
P
V
Y
N
-------
14
HHSearch
48.35
12%
-33
- C3 -
3F2E
1
?
A:
[8-90]
-------------------------------------------------------------------------
F
T
A
V
A
E
Q
V
S
A
V
L
S
Q
Y
G
I
-----
T
G
P
N
---
R
A
I
Y
Q
G
---
F
G
L
K
V
A
R
A
L
N
R
L
G
G
G
P
A
L
V
N
----
M
I
-----
N
G
-
L
K
A
Y
Y
I
S
AFNAN
P
-----
T
V
L
D
A
V
--------
T
D
-----
I
I
T
-
G
S
P
T
G
Y
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
40.40
24%
-7
- C3 -
3GWZ
1
?
A:
[186-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
L
T
-
E
A
-
G
--
Q
V
----
A
A
A
Y
D
F
S
G
A
A
T
A
V
D
I
G
G
G
RG
S
L
M
A
A
V
L
D
A
F
P
G
L
R
G
T
L
L
E
R
P
P
V
A
-----
E
E
-
A
R
E
L
L
T
G
R
G
L
A
D
R
C
E
I
L
P
G
D
F
F
E
T
I
P
D
G
A
D
V
Y
L
--------------
I
K
H
V
L
H
D
W
D
D
D
D
V
V
R
------
I
L
R
R
I
A
T
---
A
M
K
P
D
------
S
R
L
L
V
I
D
N
L
I
D
------
E
R
P
A
A
-----
S
T
L
F
--
V
--
D
L
L
L
L
V
-
L
V
G
G
A
E
R
-----
S
E
S
E
F
A
A
L
L
E
K
S
G
L
R
V
E
R
S
-
L
P
C
G
A
G
P
V
R
---
I
V
E
I
R
R
A
-----------------------------