@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EAA4_HUMAN: (2015-12-07 )
MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFILLTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQEKGASRGRGGNESAM
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.--------..--------..--------..290.......300.......310.......320.......330.......340.......350.......360..---.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480...---..------.------.------490----.......500.......510.......520.......530.......540.......550.......560..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSHG
N
S
L
F
L
R
ES
G
Q
R
L
G
R
V
G
W
L
Q
R
L
Q
E
S
L
Q
Q
R
A
L
R
T
R
L
R
L
Q
T
M
T
L
E
H
V
L
R
F
L
RRN
A
F
I
L
L
T
V
S
A
V
V
I
G
V
S
L
A
F
ALR
P
Y
Q
L
T
Y
R
Q
I
K
Y
FSF
P
G
E
L
L
M
R
M
L
Q
M
L
V
L
P
L
I
V
S
S
L
V
T
G
M
A
SLDNKATGRM
G
M
R
A
A
V
Y
Y
M
V
T
T
I
I
A
V
F
I
G
I
L
M
V
T
IIHPGKGSKEGLHREGR
I
E
TIP
T
A
D
A
F
M
D
L
I
R
N
MF
P
P
N
L
V
E
A
C
F
K
Q
F
K
T
Q
Y
S
T
R
V
V
T
R
T
M
V
RTENGSEPGASMPPPFSVEN
G
T
S
F
L
E
N
V
T
R
A
L
G
T
L
Q
E
M
L
S
F
E
ETVPVPGSAN
G
I
N
A
L
G
L
V
V
F
S
V
A
F
G
L
V
IG--------GM--------KH--------K
G
R
V
L
R
D
F
F
D
S
L
N
E
A
I
M
R
L
V
G
I
I
I
W
Y
A
P
V
G
I
L
F
L
I
AGKIL
E
M
E
D
M
A
V
L
GGQ
L
G
M
Y
T
L
T
V
I
V
G
L
F
L
H
A
G
I
V
L
P
L
I
Y
F
L
---
V
THRNPF
P
F
I
G
G
M
L
Q
A
L
I
T
A
MGTSSSS
A
T
L
P
I
T
F
R
C
L
E
EGLGV
D
R
R
I
T
R
F
V
L
PVG
A
T
VNM
D
G
T
A
L
Y
E
A
L
A
A
I
F
I
AQVN
N
Y
E
L
NL
G
Q
I
T
T
I
S
I
T
ATAASVGAAGIPQ
A
G
L
V
T
M
V
I
V
L
TSVGL---PT------E------
D
------
I
T
L
----
I
I
A
V
D
W
F
L
D
R
L
R
T
M
T
N
V
LGD
S
I
G
A
A
V
I
E
H
L
S
Q
R
E
L
E
L
Q
E
AELTLPSLG
K
P
Y
K
S
L
M
A
Q
EKGASRGRGGNESAM
69
Fugue
92.92
34%
-127
- C3 -
4OYF
-
?
A:
[9-416]
------------------------------------------------------
E
Y
P
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
-----------
L
A
V
G
G
Q
L
V
H
I
L
L
D
I
V
P
T
N
-------------------------------------
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
------------------------
E
--------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
-
Y
F
V
L
L
K
---
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
58
HHSearch
92.88
34%
-139
- C3 -
2NWL
2
?
A:
[10-416]
-------------------------------------------------------
Y
P
V
L
I
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
--
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
---------------------------------------------------------------------
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
--------
M
N
SEN
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
-
V
-
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
----
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
D
P
N
V
A
A
A
------
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
68
Fugue
88.96
33%
-126
- C3 -
1XFH
-
?
A:
[12-416]
---------------------------------------------------------
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
--
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
-------------------------------------
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
------------------------
E
--------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
I
----
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
TD
P
N
V
A
A
------
A
------
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
----------------------------------------
38
PsiBlast_CBE
75.48
37%
-115
- C3 -
2NWL
2
?
B:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
10
PsiBlast_PDB
75.41
37%
-115
- C3 -
2NWL
2
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
15
PsiBlast_PDB
75.29
37%
-118
- C3 -
4OYF
-
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
13
PsiBlast_PDB
75.27
37%
-117
- C3 -
2NWW
1
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
50
PsiBlast_CBE
74.92
37%
-112
- C3 -
2NWX
2
?
B:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
14
PsiBlast_PDB
74.84
37%
-112
- C3 -
2NWX
2
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
2
PsiBlast_PDB
74.73
37%
-106
- C3 -
4KY0
1
?
A:
[133-427]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
T
L
L
N
I
V
P
T
N
P
F
A
S
L
A
K
G
-
E
V
L
P
V
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
M
N
RNE
E
R
V
R
K
--------
S
A
E
T
L
L
R
V
F
D
G
L
A
E
A
M
Y
L
I
V
G
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
R
V
V
--
G
P
L
A
K
V
V
G
A
V
Y
T
G
L
F
L
Q
I
-
V
I
T
Y
F
I
L
L
K
---
V
F
G
I
D
P
I
K
F
I
R
K
A
K
D
A
M
I
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
E
E
E
M
G
V
D
K
G
I
F
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
T
V
L
F
V
A
N
A
I
G
H
P
L
T
L
G
Q
Q
L
V
V
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
Q
S
V
G
L
DLT
P
G
------
S
------
P
------
V
A
L
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
A
G
T
V
I
V
---
A
K
T
E
K
E
L
D
E
S
K
W
I
S
----------------------------
49
PsiBlast_CBE
74.48
37%
-112
- C3 -
2NWX
2
?
C:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
51
PsiBlast_CBE
74.47
37%
-116
- C3 -
2NWW
1
?
C:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
21
PsiBlast_CBE
74.18
37%
-105
- C3 -
4KY0
2
?
C:
[133-427]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
T
L
L
N
I
V
P
T
N
P
F
A
S
L
A
K
G
-
E
V
L
P
V
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
M
N
RNE
E
R
V
R
K
--------
S
A
E
T
L
L
R
V
F
D
G
L
A
E
A
M
Y
L
I
V
G
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
R
V
V
--
G
P
L
A
K
V
V
G
A
V
Y
T
G
L
F
L
Q
I
-
V
I
T
Y
F
I
L
L
K
---
V
F
G
I
D
P
I
K
F
I
R
K
A
K
D
A
M
I
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
E
E
E
M
G
V
D
K
G
I
F
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
T
V
L
F
V
A
N
A
I
G
H
P
L
T
L
G
Q
Q
L
V
V
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
Q
S
V
G
L
DLT
P
G
------
S
------
P
------
V
A
L
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
A
G
T
V
I
V
---
A
K
T
E
K
E
L
D
E
S
K
W
I
S
H
---------------------------
52
PsiBlast_CBE
74.10
37%
-117
- C3 -
2NWW
1
?
B:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
34
PsiBlast_CBE
73.89
37%
-118
- C3 -
3V8F
1
?
B:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
C
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
3
PsiBlast_PDB
73.82
37%
-110
- C3 -
3KBC
1
?
A:
[134-416]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
----------------------------------------
37
PsiBlast_CBE
73.67
37%
-116
- C3 -
2NWL
2
?
C:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
24
PsiBlast_CBE
73.62
37%
-111
- C3 -
3KBC
1
?
B:
[134-416]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
----------------------------------------
23
PsiBlast_CBE
73.52
37%
-111
- C3 -
3KBC
1
?
C:
[134-416]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
-
T
E
----------------------------------------
17
PsiBlast_PDB
73.50
36%
-117
- C3 -
4OYE
-
?
A:
[127-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
8
PsiBlast_PDB
73.18
37%
-118
- C3 -
3V8F
1
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
C
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
33
PsiBlast_CBE
73.05
37%
-118
- C3 -
3V8F
1
?
C:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
C
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
C
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
1
PsiBlast_PDB
72.99
38%
-121
- C3 -
4X2S
1
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
9
PsiBlast_PDB
72.40
37%
-113
- C3 -
4IZM
1
?
A:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVA
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
35
PsiBlast_CBE
72.33
37%
-118
- C3 -
4IZM
1
?
C:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
36
PsiBlast_CBE
71.36
37%
-110
- C3 -
4IZM
1
?
B:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
20
PsiBlast_CBE
70.70
38%
-120
- C3 -
4X2S
1
?
B:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
----
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------
19
PsiBlast_CBE
70.69
38%
-120
- C3 -
4X2S
1
?
C:
[134-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
LLK
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
---
P
L
------
T
------
D
PNVAAA
Y
A
M
----
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
-------------------------------------