@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EAA2_HUMAN: (2015-12-07 )
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.....--------..--------260-------........270.......280.......290.......300.......310.......320.......330.......340---.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460-----.------.------......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MASTEGANNMP
K
Q
V
E
V
R
M
HDSHLGSEEP
K
H
R
H
L
G
L
R
L
C
D
K
LGK
N
L
L
L
T
L
T
V
F
G
V
I
L
G
A
V
C
G
G
L
L
R
LASPIHP
D
V
V
M
L
I
AF
P
G
D
I
L
M
R
M
L
K
M
L
I
L
P
L
I
I
S
S
L
I
T
G
LSGLDAKASGRLG
T
R
A
M
V
Y
Y
M
S
T
T
I
I
A
A
V
L
G
V
I
L
V
L
A
IHPG
N
P
K
L
K
K
QLGPGKKND
E
V
S
S
L
D
A
F
L
D
L
I
R
N
L
F
P
E
N
L
V
Q
A
C
F
Q
Q
I
Q
T
V
T
K
K
V
L
VAPPPDEEA
N
A
T
S
A
V
V
S
L
L
N
E
T
V
T
EV
P
E
E
T
K
M
V
I
K
KGLEFKD
G
M
N
V
L
G
L
I
G
F
F
I
A
F
G
I
A
MG--------KM--------G
D
--------
Q
A
K
L
M
V
D
F
F
N
I
L
N
E
I
V
M
K
L
V
I
M
I
M
WYSP
L
G
I
A
C
L
I
CG
K
I
I
A
I
K
D
L
E
V
V
A
R
Q
L
G
M
Y
M
V
T
V
I
I
G
L
I
IHG
G
I
F
L
P
L
I
Y
F
V
VTRK---
N
P
F
S
F
F
A
G
I
F
Q
A
W
I
T
A
LGTASSAG
T
L
P
V
T
F
R
C
L
E
E
NLGI
D
K
R
V
T
R
F
V
L
PVG
A
T
INM
D
G
T
A
L
Y
E
A
V
A
A
I
F
I
A
QMN
G
V
V
LDG
G
Q
I
V
T
V
S
L
T
A
T
L
A
SVGAASIP
S
A
G
L
V
T
M
L
L
I
L
T
AVGLPT------
E
------
D
------
I
S
L
L
V
A
V
D
W
L
L
D
R
M
R
T
S
V
NVVGDSFGA
G
I
V
Y
HLSKSELDTID
S
Q
H
R
V
H
E
D
I
E
M
T
K
T
Q
S
I
Y
D
D
M
K
N
HRESNSN
Q
C
V
Y
AAH
N
S
V
I
V
DE
C
K
V
T
L
A
ANGKSADCSVEEEPWKREK
3
PsiBlast_PDB
86.13
31%
-140
- C7 -
2NWW
1
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
31
PsiBlast_CBE
85.16
31%
-137
- C7 -
2NWW
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
30
PsiBlast_CBE
84.95
31%
-138
- C7 -
2NWW
1
?
C:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
70
Fugue
84.93
35%
-126
- C7 -
4OYF
-
?
A:
[9-416]
------------------------------------------
E
Y
P
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
------------------------
I
H
L
A
V
G
G
Q
L
V
H
I
L
L
D
I
V
----------
P
T
N
P
F
G
A
L
A
N
G
-----------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
------------
E
N
E
--------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
-
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
-
V
Y
F
V
L
L
K
I
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------
60
HHSearch
84.66
34%
-144
- C7 -
2NWL
2
?
A:
[10-416]
-------------------------------------------
Y
P
V
L
I
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
-
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
Q
---
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
-----------------------------------------------------
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
--------
M
N
SEN
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
--
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
I
-
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
D
P
N
V
A
A
A
------
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
-----------------------------------------------------------------------------
39
PsiBlast_CBE
84.61
32%
-144
- C7 -
3V8F
1
?
C:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
C
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
40
PsiBlast_CBE
84.53
32%
-145
- C7 -
3V8F
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
C
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
8
PsiBlast_PDB
84.42
32%
-145
- C7 -
3V8F
1
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
C
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
2
PsiBlast_PDB
84.38
31%
-133
- C7 -
1XFH
-
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
G
-------------------------------------------------------------------------
36
PsiBlast_CBE
84.31
31%
-148
- C7 -
3V8G
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
-------
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
5
PsiBlast_PDB
83.69
31%
-139
- C7 -
4OYF
-
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
---------
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
69
Fugue
83.50
32%
-141
* C7 *
1XFH
-
?
A:
[12-416]
----------------------------------------------
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
---
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
-----------------------------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
--------
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
V
H
V
V
--
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
I
-
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
-
E
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
TD
P
N
V
A
A
------
A
------
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
----------------------------------------------------------------------------
55
PsiBlast_CBE
83.50
31%
-131
- C7 -
4OYG
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
33
PsiBlast_CBE
83.48
31%
-148
- C7 -
3V8G
1
?
E:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
--------
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
14
PsiBlast_PDB
83.47
31%
-131
- C7 -
4OYG
1
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
34
PsiBlast_CBE
83.46
31%
-146
- C7 -
3V8G
1
?
D:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
N
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
51
PsiBlast_CBE
83.45
31%
-131
- C7 -
4OYG
1
?
F:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
4
PsiBlast_PDB
83.23
31%
-138
- C7 -
2NWX
2
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
37
PsiBlast_CBE
83.21
31%
-143
- C7 -
3KBC
1
?
C:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
11
PsiBlast_PDB
83.18
31%
-146
- C7 -
4P3J
-
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
G
-------------------------------------------------------------------------
38
PsiBlast_CBE
83.13
31%
-143
- C7 -
3KBC
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
7
PsiBlast_PDB
83.12
31%
-143
- C7 -
3KBC
1
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
13
PsiBlast_PDB
82.73
31%
-133
- C7 -
4IZM
1
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVA
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
29
PsiBlast_CBE
82.71
31%
-140
- C7 -
2NWX
2
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
---------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
56
PsiBlast_CBE
82.60
31%
-135
- C7 -
2NWL
2
?
C:
[47-416]
---------------------------------------------------------------------------------
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
----
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
49
PsiBlast_CBE
82.58
31%
-135
- C7 -
4IZM
1
?
C:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
16
PsiBlast_PDB
82.42
31%
-134
- C7 -
2NWL
2
?
A:
[47-416]
---------------------------------------------------------------------------------
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
50
PsiBlast_CBE
81.77
31%
-130
- C7 -
4IZM
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
1
PsiBlast_PDB
81.29
32%
-146
- C7 -
4X2S
1
?
A:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
28
PsiBlast_CBE
80.73
31%
-136
- C7 -
2NWX
2
?
C:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
----
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
21
PsiBlast_CBE
80.48
32%
-144
- C7 -
4X2S
1
?
C:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
YLMNSENE
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
G
T
L
V
----------------------------------------------------------------------
22
PsiBlast_CBE
80.42
32%
-144
- C7 -
4X2S
1
?
B:
[19-416]
----------------------------------------------------
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
-
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------
57
PsiBlast_CBE
80.38
31%
-138
- C7 -
2NWL
2
?
B:
[47-416]
---------------------------------------------------------------------------------
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
---
G
I
H
L
A
V
G
---------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
G
---------------------------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
-
Y
V
M
A
E
Q
G
V
H
V
V
G
-
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
----
I
L
L
V
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
------
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
---
A
K
T
E
--------------------------------------------------------------------------