@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EAA1_HUMAN: (2015-12-07 )
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230..-.-....240.......250.......260------..--------.......270.......280.......290.......300.......-310.......320.......330.......340.---......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.------.------.....470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKSNGEEPKMG
G
R
M
E
R
F
Q
Q
G
V
R
K
R
T
L
L
A
K
K
K
V
Q
N
I
T
K
E
D
V
K
S
Y
L
F
RN
A
F
V
L
L
T
V
T
A
V
I
V
G
T
I
L
GFTLR
P
Y
RMS
Y
R
E
V
K
Y
FSF
P
G
E
L
L
M
R
M
L
Q
M
L
V
L
P
L
I
I
S
S
L
V
T
G
M
A
A
LDSKASGKM
G
M
R
A
V
V
Y
Y
M
T
T
T
I
I
A
V
V
I
G
I
I
I
V
I
I
I
HPGKG
T
K
E
N
MHREG
K
I
V
R
V
T
A
A
D
A
F
L
D
L
I
R
N
MF
P
P
N
L
V
E
A
C
F
K
Q
F
K
TNYEK
R
S
F
K
V
P
IQAN
E
T
L
V
G
A
V
I
N
N
V
S
E
A
M
E
T
L
T
R
I
T
E
E
LVPV-P-GSVN
G
V
N
A
L
G
L
V
V
F
S
M
C
F
G
F
V
IGN
M
--------
K
E
--------
Q
G
Q
A
L
R
E
F
F
D
S
L
N
E
A
I
M
R
L
V
A
V
I
M
W
Y
A
P
V
G
I
L
F
L
I
AG
K
I
V
E
M
EDMGV-IGG
Q
L
A
M
Y
T
V
T
V
I
V
G
L
L
I
H
A
V
I
V
L
P
L
L
Y
F
L
VTRK---N
P
W
V
F
I
G
G
L
L
Q
A
L
I
T
A
LGTSSSS
A
T
L
P
I
T
F
K
C
LEENNG
V
D
K
R
V
T
R
F
V
L
PVG
A
T
INM
D
G
T
A
L
Y
E
A
L
A
A
I
F
I
AQVN
N
F
E
L
NFG
Q
I
I
T
I
S
I
T
A
T
AASIGAAGIPQ
A
G
L
V
T
M
V
I
V
L
TSVGLPTD------
D
------
I
T
L
I
I
A
V
D
W
F
L
D
R
L
R
T
T
T
N
V
LG
D
S
L
G
A
G
I
V
E
H
L
S
R
H
E
LKNR
D
V
E
M
G
N
S
V
I
E
E
N
EMK
K
P
Y
Q
L
IAQDNETEKPIDSETKM
48
PsiBlast_CBE
92.94
32%
-138
- C6 -
3V8F
1
?
B:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
C
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
69
Fugue
92.58
35%
-123
- C6 -
4OYF
-
?
A:
[9-416]
----------------------------------------------
E
Y
P
V
L
Q
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
-----------
I
H
L
A
V
G
G
Q
L
V
H
I
L
L
D
I
V
P
T
N
--------------------
P
F
G
A
L
A
N
--
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
S
E
-
N
-----------------------
E
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
--
Y
V
M
A
E
Q
G
V
H
-
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
-
I
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
58
HHSearch
92.36
34%
-129
- C6 -
2NWL
2
?
A:
[10-416]
-----------------------------------------------
Y
P
V
L
I
K
I
L
I
G
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
H
L
A
V
G
G
-
Q
Q
-
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
------------------------------------------------------
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
--------
M
N
SEN
E
K
V
R
K
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
Y
V
M
A
E
Q
G
-
V
H
--
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
Y
F
V
L
L
K
I
-
Y
G
I
---
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
-
M
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
D
P
N
V
A
A
A
------
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
7
PsiBlast_PDB
92.02
32%
-135
- C6 -
4P1A
-
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
-----------------------------------------
47
PsiBlast_CBE
91.77
32%
-138
- C6 -
3V8F
1
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
C
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
12
PsiBlast_PDB
91.53
32%
-138
- C6 -
3V8F
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
C
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
C
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
49
PsiBlast_CBE
91.21
32%
-137
- C6 -
3KBC
1
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
42
PsiBlast_CBE
91.08
32%
-135
- C6 -
3V8G
1
?
D:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
G
I
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
8
PsiBlast_PDB
91.06
32%
-138
- C6 -
4P3J
-
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
-------------------------------------------
10
PsiBlast_PDB
90.92
32%
-136
- C6 -
3V8G
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
C
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
C
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
13
PsiBlast_PDB
90.89
32%
-136
- C6 -
3KBC
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
50
PsiBlast_CBE
90.80
32%
-136
- C6 -
3KBC
1
?
B:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
6
PsiBlast_PDB
90.48
32%
-135
- C6 -
4P19
-
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
C
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
C
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
----------------------------------------
54
PsiBlast_CBE
90.32
32%
-129
- C6 -
4OYG
1
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
16
PsiBlast_PDB
90.32
32%
-131
- C6 -
2NWL
2
?
A:
[25-412]
----------------------------------------------------------
I
V
G
L
I
L
G
H
----
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
-------------------------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
53
PsiBlast_CBE
90.23
32%
-130
- C6 -
4OYG
1
?
D:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
52
PsiBlast_CBE
90.15
32%
-130
- C6 -
4OYG
1
?
E:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
15
PsiBlast_PDB
89.92
32%
-136
- C6 -
4OYE
-
?
A:
[13-405]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
---------------------------------------------
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
51
PsiBlast_CBE
89.77
32%
-129
- C6 -
4OYG
1
?
F:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
MNSENEKV
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
14
PsiBlast_PDB
89.77
32%
-130
- C6 -
4OYG
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
H
Q
A
----------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
A
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
1
PsiBlast_PDB
89.73
33%
-134
- C6 -
4X2S
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
56
PsiBlast_CBE
89.61
32%
-133
- C6 -
2NWL
2
?
C:
[25-412]
----------------------------------------------------------
I
V
G
L
I
L
G
H
----
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
G
Q
----------------------------
Q
F
Q
----------
P
--------------------
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
30
PsiBlast_CBE
89.42
32%
-127
- C6 -
2NWW
1
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
57
PsiBlast_CBE
89.39
32%
-134
- C6 -
2NWL
2
?
B:
[25-412]
----------------------------------------------------------
I
V
G
L
I
L
G
H
----
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
--
G
A
G
I
H
L
A
V
G
---------------------------------------------------------------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
A
I
T
Y
L
M
N
SEN
E
K
V
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
3
PsiBlast_PDB
89.21
32%
-129
- C6 -
2NWW
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
29
PsiBlast_CBE
88.97
32%
-126
- C6 -
2NWX
2
?
B:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
---------
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
31
PsiBlast_CBE
88.61
32%
-126
- C6 -
2NWW
1
?
B:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
21
PsiBlast_CBE
88.25
33%
-134
- C6 -
4X2S
1
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
G
T
L
V
----------------------------------------
22
PsiBlast_CBE
88.16
33%
-134
- C6 -
4X2S
1
?
B:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
S
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
R
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
28
PsiBlast_CBE
87.97
32%
-126
- C6 -
2NWX
2
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
----
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
4
PsiBlast_PDB
87.72
32%
-126
- C6 -
2NWX
2
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
L
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
-----
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
S
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
C
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
P
N
V
A
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
45
PsiBlast_CBE
87.40
32%
-126
- C6 -
4IZM
1
?
C:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
11
PsiBlast_PDB
87.28
32%
-124
- C6 -
4IZM
1
?
A:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
Y
GI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVA
A
A
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------
46
PsiBlast_CBE
86.20
32%
-122
- C6 -
4IZM
1
?
B:
[20-412]
---------------------------------------------------------
L
I
L
G
A
I
V
G
L
I
L
G
H
Y
G
Y
A
H
A
V
H
T
Y
V
K
P
F
G
D
L
F
V
R
L
L
K
M
L
V
M
P
I
V
F
A
S
C
V
V
G
A
A
S
I
S
P
A
R
L
G
R
V
G
V
K
I
V
V
Y
Y
L
L
T
S
A
F
A
V
T
L
G
I
I
M
A
R
L
F
N
P
G
A
G
I
--
H
L
A
V
G
G
Q
Q
F
Q
P
H
Q
A
P
P
L
V
H
I
L
L
D
I
V
P
T
N
P
F
G
A
L
A
N
G
--------------
Q
V
L
P
T
I
F
F
A
I
I
L
G
I
--
A
I
T
Y
L
M
N
S
E
N
E
------------------------------
K
V
--------
R
K
--------
S
A
E
T
L
L
D
A
I
N
G
L
A
E
A
M
Y
K
I
V
N
G
V
M
Q
Y
A
P
I
G
V
F
A
L
I
A
---
Y
V
M
A
E
Q
G
V
H
V
V
G
E
L
A
K
V
T
A
A
V
Y
V
G
L
T
L
Q
I
L
L
V
----
Y
F
V
L
L
K
I
YGI
D
P
I
S
F
I
K
H
A
K
D
A
M
L
T
A
F
V
T
R
S
S
S
G
T
L
P
V
T
M
R
V
A
K
E
M
-
G
I
S
E
G
I
Y
C
F
T
L
P
L
G
A
T
I
N
M
D
G
T
A
L
Y
Q
G
V
A
T
F
F
I
A
N
A
L
G
S
H
L
T
V
G
Q
Q
L
T
I
V
L
T
A
V
L
A
S
I
G
T
A
G
V
P
G
A
G
A
I
M
L
A
M
V
L
H
S
V
G
L
P
L
T
------
D
PNVAAA
Y
A
M
I
L
G
I
D
A
I
L
D
M
G
R
T
M
V
N
V
T
G
D
L
T
G
T
A
I
V
A
K
T
E
--------------------------------------------