@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CTR4_HUMAN: (2015-12-07 )
MARGLPTIASLARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSSWLNHTFSAISLLVILFIVILGFILAQPHNWSADEGGFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIVLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPEPGELKPALRPYLGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILLLLLTSVMFLLSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGLAVYFGYGIRHSKENQRELPGLNSTHYVVFPRGSLEETVQAMQPPSQAPAQDPGHME
Atome Classification :
(20 SA)
-.........10........20........30--------------........40..-......50........60........70.-------.......80........90---........100.--------------......110----------..-...-----..------120.--...-...130.......140.......150.......160..-.....170.......180..---...-----..190.......200.......210..----..--..-.220-------.-.--...----..---230--..--.....--..-240........----250.......--------260.......270........280....--...290--......---------------.-.300..-.......------310.....-..-320.......330....---...340.......350.......-360........370.....-----------..380..-------.....390.----......400.......410.......420.......430......-.-440...-----....450.......460----........470.---......480-------.........490.......500-......-----------..510....-----------...520.......530.......540.......550.......560.......-------------570.......580.......590.......600.......610.......620.-----......630...-------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MARGL
P
T
I
A
S
L
A
R
L
C
Q
K
L
N
RLKPLED
S
T
M
E
T
--------------
S
L
R
R
C
L
S
T
L
D
L
T
-
L
L
GVGGMVGS
G
L
Y
V
L
T
G
A
V
A
K
EVAG
P
A
V
L
-------
L
S
F
G
V
A
A
V
A
S
L
L
A
A
L
C
Y
A
E
---
F
GARVPRTG
S
A
Y
--------------
L
F
T
Y
V
S
M
G
E
----------
L
W
-
A
F
L
-----
I
G
------
W
N
V
L
--
L
E
Y
-IIG
G
A
A
V
A
R
A
W
S
G
Y
L
D
S
M
F
S
H
S
I
R
N
F
T
E
THVGSWQVPL-LGH
Y
P
D
F
L
A
A
G
I
I
L
L
A
S
A
F
V
---
S
C
G
-----
A
R
V
S
S
W
L
N
H
T
F
S
A
I
S
L
L
V
I
L
F
I
V
I
L
G
F
----
I
L--AQ-PHNW-------S-A--DEG----GF---A----PF--GF
S
G
V
--
M
A
-
G
T
-
A
S
C
F
Y
A
F
V
----
G
F
D
V
IAAS
S
E
--------EAQNPRRSV
P
L
A
-
I
A
I
S
L
A
I
AA
G
A
Y
I
L
V
--
S
T
V
L
T
---
L
MVPWH---------------S-LD--P
D
-
S
A
L
A
D
A
F
------
Y
QRGY
R
W
A
-
G
F
-
I
V
AAG
S
I
C
A
M
N
T
V
L
L
S
L
---
L
F
S
L
P
R
I
V
Y
A
MAAD
G
L
F
F
Q
V
F
A
H
-V-HPRTQVP
V
A
G
T
L
A
F
G
L
L
-----------
T
A
F
L
A
L
L
-------
L
D
L
E
S
L
V
Q
F
----
L
S
L
G
T
L
L
A
Y
T
F
V
A
T
S
I
I
V
L
R
F
QKSSPPSSPGPASPGPLTKQQS
S
F
-
S
-
D
H
L
Q
L
V
-----
G
T
V
HASVPEPGEL
K
P
A
-----
L
R
P
Y
L
G
FLDGYS---P
G
A
V
V
T
W
---------
A
L
G
V
M
L
A
S
A
I
T
I
G
C
V
L
V
FGN
S
--
T
L
HLP
H
-----------
W
G
Y
I
L
L
L
L
L
-----------
T
S
V
M
F
L
L
S
L
L
V
LGA
H
Q
Q
Q
Y
R
E
D
L
F
QIP
M
V
P
L
I
P
A
L
S
I
V
L
N
I
C
L
M
L
K
L
S
Y
L
T
W
V
-------------
R
F
S
I
W
L
L
M
G
L
A
V
Y
F
GYGIRHSKE
N
Q
RELPGLNST
H
Y
V
V
FPRG
S
L
E
E
T
V
Q
A
MQPP-----SQAPAQDPGHME-------------------------------------------------
31
Fugue
86.71
21%
-132
- C3 -
3GIA
7
Y609_METJA
A:
[3-435]
----------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
-
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
-
G
R
N
L
P
-------
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
---
L
G
A
K
I
V
S
N
A
G
P
I
--------------
A
F
I
H
K
A
I
G
D
N---------
I
I
-
T
G
A
-----
L
S
------
I
L
L
W
--
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
---------------
P
I
-
N
T
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
---
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
----
I
T
--
I
H
-
P
S
Y
V
-------
I
-
P
--
D
-------
L
---
A
----
P
S
--
A
V
S
G
M
--
I
F
-
A
S
-
A
I
F
F
L
S
Y
M
----
G
F
G
V
I
T
N
A
S
E
--------
H
I
E
N
P
K
K
N
V
P
R
A
-
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
--
A
I
S
A
I
---
G
N
L
P
I
D
---------------
E
-
L
I
K
A
S
E
-
N
A
L
A
V
A
A
------
K
P
F
L
G
N
L
G
-
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
---
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
-
K
-
V
W
F
K
S
T
--
E
G
L
Y
I
T
S
A
L
-----------
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
----
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
V
F
-------------
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
---------------------------------------------------------------------------------------
21
HHSearch
80.35
23%
-132
* C3 *
3GIA
6
Y609_METJA
A:
[3-369]
----------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
-
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
-
I
A
G
R
N
L
P
-------
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
---
L
G
A
K
I
V
S
N
A
G
P
I
--------------
A
F
I
H
K
A
I
G
D
----------
N
I
I
T
G
A
-----
L
S
------
I
L
L
W
--
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
----------------
F
N
I
A
I
T
E
I
G
I
V
A
F
F
T
A
L
N
---
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
----
I
T
--
I
H
-
P
S
Y
V
-------
I
-
P
---------
D
L
---
A
----
P
S
--
A
V
S
G
M
--
I
F
-
A
S
-
A
I
F
F
L
S
Y
M
----
G
F
G
V
I
T
N
A
S
E
--------
H
I
E
N
P
K
K
N
V
P
R
A
-
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
--
A
I
S
A
I
---
G
N
L
P
I
D
---------------
E
-
L
I
K
A
S
E
-
N
A
L
A
V
A
A
------
K
P
F
L
G
N
L
G
-
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
---
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
-
K
-
V
-
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
-----------
G
V
L
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
----
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
-
Y
-
Y
Q
W
I
T
N
-----
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-----
F
E
I
I
Y
R
K
V
T
K
R
T
---
F
S
N
N
M
Y
V
---------
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.32
23%
-135
- C3 -
3GI8
-
Y609_METJA
C:
[5-361]
------------------------------------------------
N
K
K
L
S
L
W
E
A
V
-
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
-
I
A
G
R
N
L
P
-------
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
---
L
G
A
K
I
V
S
N
A
G
P
I
--------------
A
F
I
H
K
A
I
G
D
NIITGALSIL
L
W
-----------------------
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
---
N
I
A
I
T
E
I
-------------
G
I
V
A
F
F
T
A
L
N
---
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
A
L
L
I
L
G
L
F
I
F
A
G
L
----
I
T
--
I
H
-
P
S
Y
V
-------
I
-
P
--
D
-------
L
---
A
----
P
S
--
A
V
S
G
M
--
I
F
-
A
S
-
A
I
F
F
L
S
Y
M
----
G
F
G
V
I
T
N
A
S
E
--------
H
I
E
N
P
K
K
N
V
P
R
A
-
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
--
A
I
S
A
I
---
G
N
L
P
I
D
---------------
E
-
L
I
--
K
A
-
S
E
N
A
L
A
V
------
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
---
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
--------------
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
----
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
-
Y
-
Y
Q
W
I
T
N
-----
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-----
F
E
I
I
Y
R
K
V
T
K
R
T
---
F
S
N
N
M
Y
V
---------
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.31
23%
-133
- C3 -
3GIA
6
Y609_METJA
A:
[5-361]
------------------------------------------------
N
K
K
L
S
L
W
E
A
V
-
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
-
I
A
G
R
N
L
P
-------
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
---
L
G
A
K
I
V
S
N
A
G
P
I
--------------
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
-----------------------
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
T
F
---
N
I
A
I
T
E
I
-------------
G
I
V
A
F
F
T
A
L
N
---
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
----
I
T
--
I
H
-
P
S
Y
V
-------
I
-
P
--
D
-------
L
---
A
----
P
S
--
A
V
S
G
M
--
I
F
-
A
S
-
A
I
F
F
L
S
Y
M
----
G
F
G
V
I
T
N
A
S
E
--------
H
I
E
N
P
K
K
N
V
P
R
A
-
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
--
A
I
S
A
I
---
G
N
L
P
I
D
---------------
E
-
L
I
--
K
A
-
S
E
N
A
L
A
V
------
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
---
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
--------------
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
----
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
-
Y
-
Y
Q
W
I
T
N
-----
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-----
F
E
I
I
Y
R
K
V
T
K
R
T
---
F
S
N
N
M
Y
V
---------
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.62
23%
-134
- C3 -
3GI9
-
Y609_METJA
C:
[5-361]
------------------------------------------------
N
K
K
L
S
L
W
E
A
V
-
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
-
I
A
G
R
N
L
P
-------
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
---
L
G
A
K
I
V
S
N
A
G
P
I
--------------
A
F
I
H
K
A
I
G
D
N
I
I
T
G
A
L
S
I
L
L
W
-----------------------
M
S
Y
-
V
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
-
A
P
I
N
T
F
---
N
I
A
I
T
E
I
-------------
G
I
V
A
F
F
T
A
L
N
---
F
F
G
-----
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
----
I
T
--
I
H
-
P
S
Y
V
-------
I
-
P
--
D
-------
L
---
A
----
P
S
--
A
V
S
G
M
--
I
F
-
A
S
-
A
I
F
F
L
S
Y
M
----
G
F
G
V
I
T
N
A
S
E
--------
H
I
E
N
P
K
K
N
V
P
R
A
-
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
--
A
I
S
A
I
---
G
N
L
P
I
D
---------------
E
-
L
I
--
K
A
-
S
E
N
A
L
A
V
------
A
A
K
P
F
L
G
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
---
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
-
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
--------------
F
A
L
L
-------
F
N
M
E
G
V
A
S
I
----
T
S
A
V
F
M
V
I
Y
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
G
R
K
E
I
V
I
F
S
F
I
V
V
L
G
V
F
L
L
L
L
-
Y
-
Y
Q
W
I
T
N
-----
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
-----
F
E
I
I
Y
R
K
V
T
K
R
T
---
F
S
N
N
M
Y
V
---------
K
S
L
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
77.97
21%
-135
- C3 -
3L1L
2
ADIC_ECO57
A:
[7-380]
------------------------------------------------
A
H
K
V
G
L
I
P
V
T
-
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
-
T
-
G
G
I
A
I
-------
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
---
M
S
F
L
D
P
S
P
G
G
S
Y
--------------
A
Y
A
R
R
C
F
G
P
----------
F
L
-
G
Y
Q
-----
T
N
------
V
L
Y
W
--
L
A
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
P
I
L
K
D
P
--------
W
--------
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
---
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
--
F
R
-
G
E
T
Y
-------
M
-
A
--------------------------
A
I
--
Q
S
-
T
L
-
N
V
T
L
W
S
F
I
----
G
V
E
S
A
S
V
A
A
G
--------
V
V
K
N
P
K
R
N
V
P
I
A
-
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
--
T
T
A
I
M
---
G
M
I
P
N
A
---------------
A
-
L
R
V-
S
A
-
S
P
F
G
D
A
A
------
R
M
A
L
G
D
T
A
-
G
A
-
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
---
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
-
V
-
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
-----------
M
T
I
F
Q
L
S
SISPNAT
K
E
F
G
L
V
S
S
V
----
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
-
V
-
V
G
S
G
A
K
-----
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
Y
-----
A
L
N
Y
N
R
L
H
K
N
P
Y
---
P
L
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.87
25%
-132
- C3 -
3OB6
1
ADIC_ECOLI
A:
[13-339]
------------------------------------------------------
I
P
V
T
-
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
--
G
G
I
A
I
-------
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
---
M
S
F
L
D
P
S
P
G
G
S
Y
--------------
A
Y
A
R
R
C
F
G
P
----------
F
L
-
G
Y
Q
-----
T
--------
N
V
L
Y
W
L
A
C
-
W
I
G
A
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
-----------------
P
I
-
L
K
D
-
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
--
F
R
-
G
E
T
Y
-------
M
-
A
A
W
N
V
S
----
G
L
---
G
----
T
F
--
G
--
A
I
--
Q
S
-
T
L
-
N
V
T
L
W
S
F
I
----
G
V
E
S
A
S
V
A
A
G
--------
V
V
K
N
P
K
R
N
V
P
I
A
-
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
--
T
T
A
I
M
---
G
M
I
P
N
A
---------------
A
-
L
R
--
V
S
A
S
P
F
G
D
A
A
------
R
M
A
L
G
D
T
A
-
G
A
-
I
V
---
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
-
V
-
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
-----------
M
T
I
F
Q
L
S
-------
S
I
S
P
G
L
V
S
S
----
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
F
L
Y
C
I
W
-
A
-
V
V
G
S
G
A
-----
K
E
V
M
W
S
F
V
T
L
M
V
I
T
A
M
-----
Y
A
L
N
Y
N
R
L
H
K
N
P
---
Y
P
L
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
72.73
25%
-137
- C3 -
3L1L
2
ADIC_ECO57
A:
[13-339]
------------------------------------------------------
I
P
V
T
-
L
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
--
G
G
I
A
I
-------
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
---
M
S
F
L
D
P
S
P
G
G
S
Y
--------------
A
Y
A
R
R
C
F
G
P
----------
F
L
-
G
Y
Q
-----
T
--------
N
V
L
Y
W
L
A
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
-----------------
P
I
-
L
K
D
-
P
W
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
--
F
R
-
G
E
T
Y
-------
M
-
A
--------------------------
A
I
--
Q
S
-
T
L
-
N
V
T
L
W
S
F
I
----
G
V
E
S
A
S
V
A
A
G
--------
V
V
K
N
P
K
R
N
V
P
I
A
-
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
--
T
T
A
I
M
---
G
M
I
P
N
A
---------------
A
-
L
R
--
V
S
A
S
P
F
G
D
A
A
------
R
M
A
L
G
D
T
A
-
G
A
-
I
V
---
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
-
V
-
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
-----------
M
T
I
F
Q
L
S
-------
S
I
S
P
N
A
T
K
E
----
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
-
F
-
L
Y
C
I
W
A
-----
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
V
I
T
A
M
Y
A
L
N
Y
N
---
R
L
H
K
N
P
Y
---------
P
L
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.56
25%
-132
- C3 -
3LRB
-
ADIC_ECO57
A:
[13-339]
------------------------------------------------------
I
P
V
T
-
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
--
G
G
I
A
I
-------
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
---
M
S
F
L
D
P
S
P
G
G
S
Y
--------------
A
Y
A
R
R
C
F
G
P
----------
F
L
-
G
Y
Q
-----
T
--------
N
V
L
Y
W
L
A
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
-----------------
P
I
-
L
K
D
-
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
--
F
R
-
G
E
T
Y
-------
M
-
A
A
W
N
V
S
----
G
L
---
G
----
T
F
--
G
--
A
I
--
Q
S
-
T
L
-
N
V
T
L
W
S
F
I
----
G
V
E
S
A
S
V
A
A
G
--------
V
V
K
N
P
K
R
N
V
P
I
A
-
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
--
T
T
A
I
M
---
G
M
I
P
N
--------------------------------------------
T
A
-
G
A
-
I
V
---
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
-
V
-
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
-----------
M
T
I
F
Q
L
S
-------
S
I
S
P
N
A
T
K
E
----
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
-
F
-
L
Y
C
I
W
A
-----
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
V
I
T
A
M
Y
A
L
N
Y
N
---
R
L
H
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.15
24%
-127
- C3 -
3NCY
-
ADIC_SALTY
A:
[13-333]
------------------------------------------------------
I
P
V
T
-
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
A
A
T
--
G
G
I
A
I
-------
Y
G
W
L
V
T
I
I
G
A
L
A
L
S
M
V
Y
A
K
---
M
S
S
L
D
P
S
P
G
G
S
Y
--------------
A
Y
A
R
R
C
F
G
P
----------
F
L
-
G
Y
Q
-----
T
N
------
V
L
Y
W
--
L
A
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
-----------------
P
I
-
L
K
D
-
P
L
V
L
T
L
T
C
V
A
V
L
W
I
F
V
L
L
N
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
V
P
I
V
G
I
A
V
F
G
W
----
F
W
--
F
K
-
G
E
------------W-
N
V
S
----
G
M
---
N
----
T
F
--
G
--
A
I
--
Q
S
-
T
L
-
N
V
T
L
W
S
F
I
----
G
V
E
S
A
S
V
A
A
G
--------
V
V
K
N
P
K
R
N
V
P
I
A
-
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
--
T
T
A
I
M
---
G
M
I
P
N
A
---------------
A
-
L
R
--
V
S
A
S
P
F
G
D
A
A
------
R
M
A
L
G
D
T
A
-
G
A
-
I
V
---
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
--------
T
P
V
A
G
L
L
I
V
G
V
L
-----------
M
T
I
F
Q
F
S
-------
S
M
S
P
N
A
A
K
E
----
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
L
Y
L
L
I
T
F
V
A
-
F
-
V
Y
C
I
W
A
-----
V
I
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
V
I
T
A
L
Y
A
L
N
Y
N
---
R
I
H
K
N
P
Y
---------
P
L
D
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.14
25%
-127
- C3 -
3LRC
-
ADIC_ECO57
A:
[13-339]
------------------------------------------------------
I
P
V
T
-
L
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
T
--
G
G
I
A
I
-------
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
---
M
S
F
L
D
P
S
P
G
G
S
Y
--------------
A
Y
A
R
R
C
F
G
P
----------
F
L
-
G
Y
Q
-----
T
--------
N
V
L
Y
W
L
A
C
-
W
I
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
-----------------
P
I
-
L
K
D
-
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
-----
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
----
F
W
--
F
R
-
G
E
T
Y
-------
M
-
A
A
W
N
V
S
----
G
L
---
G
----
T
F
--
G
--
A
I
--
Q
S
-
T
L
-
N
V
T
L
W
S
F
I
----
G
V
E
S
A
S
V
A
A
G
--------
V
V
K
N
P
K
R
N
V
P
I
A
-
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
--
T
T
A
I
M
---
G
M
I
P
N
--------------------------------------------
T
A
-
G
A
-
I
V
---
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
-
V
-
N
-
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
-----------
M
T
I
F
Q
L
S
-------
S
I
S
P
N
A
T
K
E
----
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
Y
L
A
V
T
T
I
A
-
F
-
L
Y
C
I
W
A
-----
V
V
G
S
G
A
K
E
V
M
W
S
F
V
T
L
-----
M
V
I
T
A
M
Y
A
L
N
Y
N
---
R
L
H
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
69.86
13%
-109
- C2 -
2J7U
1
A:
[8-618]
-----------
M
D
V
I
G
E
R
I
K
R
I
K
E
E
H
N
S
T
W
H
Y
--------------
D
D
E
N
P
Y
K
T
W
A
Y
H
G
S
Y
E
V
S
S
M
I
N
G
V
V
K
L
L
T
----
K
P
W
D
V
V
P
M
V
-------
T
Q
M
A
M
T
D
T
T
P
F
G
Q
Q
R
V
F
K
E
KVD
T
R
T
P
R
P
L
P
G
T
R
K
--------------
V
M
E
I
T
-
A
E
W
----------
L
W
-
R
T
L
G
R
N
K
R
P
R
------
L
C
T
R
--
E
E
F
-
T
K
K
V
R
T
N
D
S
A
K
A
A
V
E
D
E
E
F
W
K
L
V
D
R
E
R
E
L
H
K
L
G
K
C
G
S
C
-
V
S
R
A
I
W
Y
M
W
L
G
A
R
Y
L
E
F
E
A
L
---
G
---------------------------
F
L
N
E
D
H
W
----
F
S
--
R
E
-
N
S
Y
S
-------
G
-
V
--
E
G
E
----
G
L
---
H
----
K
L
--
G
Y
I
L
R
--
D
I
-
S
K
-
I
P
G
G
A
M
Y
A
D
D
T
A
G
W
D
T
R
I
-
T
E
D
--------
D
L
H
N
E
E
K
I
I
Q
Q
M
-
D
P
E
H
R
Q
L
A
N
A
I
F
K
L
T
YQ
N
K
V
V
K
---
V
Q
R
P
--------------------
T
--
P
T
-
G
T
V
M
D
I
I
------
S
R
K
D
Q
R
----------
G
S
G
Q
V
G
T
Y
G
L
N
T
F
---
T
N
M
E
A
Q
L
V
R
Q
M
E
G
E
G
V
L
T
K
A
D
L
E
-------
N
P
H
L
L
E
K
K
I
T
Q
W
L
-----------
E
T
K
G
V
E
R
-------
L
K
R
M
A
I
S
G
D
----
D
C
V
V
K
P
I
D
D
R
F
A
N
A
L
L
A
L
N
D
M
G
K
V
R
K
D
I
P
Q
W
Q
P
S
K
G
W
H
D
W
Q
Q
V
P
F
C
S
-
H
H
F
H
E
L
I
M
KDG
R
K
L
V
V
P
C
R
P
Q
D
E
L
I
G
R
-----
A
R
--------
I
S
---
Q
G
A
G
W
S
L
---------
R
E
T
A
C
L
G
K
A
Y
A
Q
M
W
S
L
M
Y
------
F
H
R
R
D
-----------
L
R
L
A
S
N
A
I
C
-----------
S
A
V
---------------
P
V
H
W
V
P
T
S
R
T
T
W
S
I
H
A
H
H
Q
W
M
T
T
E
D
M
L
T
V
W
N
R
V
W
I
-------------
E
E
N
P
W
M
E
D
K
T
P
V
T
T
W
E
N
V
P
Y
L
G
K
R
E
D
Q
W
C
G
---
S
L
I
G
L
T
S
R
A
T
W
A
Q
N
I
P
T
A
I
Q
Q
-----
V
R
S
L
I
G
N
E
E
F
L
D
YM-----------------------------------------------
37
Fugue
67.28
16%
-131
- C3 -
2YIC
2
KGD_MYCS2
A:
[7-868]
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
D
N
T
R
F
RST
L
W
D
L
D
REFQRK
K
L
R
D
I
L
S
V
L
R
D
A
-
Y
C
R
H
V
G
V
E
---
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
TKHDKPT
V
A
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
---
F
L
Q
T
K
Y
V
G
Q
K
R
F
SLEGAET
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
----------
L
D
-
E
V
V
-----
I
A
M
P
HRG
R
L
N
V
L
--
A
N
I
-
V
--
G
K
P
Y
S
Q
I
F
S
E
F
E
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
F
G
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
---
A
K
Q
-----
D
L
L
D
T
G
E
E
G
S
D
N
R
F
S
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
--
A
E
-
T
L
N
L
-------
A
-
L
--
L
R
G
YRTG
G
T
---
I
----
H
I
--
V
V
N
N
Q
--
I
G
-
F
T
-
T
A
P
T
D
S
R
S
----
S
E
Y
C
T
D
V
A
K
M
IG
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
--
D
M
L
C
Y
---
R
R
R
G
H
N
---------------
E
-
G
D
--
D
P
-
S
M
T
Q
P
Y
M
------
Y
D
V
I
D
T
K
R
-
G
S
-
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
---
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
V
R
E
L
-
E
K
H
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
ALPEGFTVH
P
R
V
R
P
V
L
-------
E
K
R
R
E
M
A
Y
E
GRID
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
-
E
F
T
P
L
Q
L
L
-----
A
T
N
P
D
G
T
P
T
G
G
K
F
L
V
Y
NSALS
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
QFGDFVN
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
EGQGPDHTS
G
R
I
E
R
F
L
Q
L
WAEGS
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
-
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
EEPMYTDGEGDRN
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
KEKFW
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
ILPDHFTG
L
K
R
I
S
R
R
AMSAPSSGS
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
33
Fugue
63.10
14%
-108
- C3 -
4DJK
-
GADC_ECOLI
A:
[12-501]
-------------------------
Q
L
T
L
L
G
F
--------------
F
A
I
T
A
S
M
V
M
A
V
Y
-
E
Y
P
T
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
-------
C
A
A
E
M
A
T
--------------------
V
D
G
W
G
V
F
--------------
A
W
V
S
N
T
L
G
P
----------
R
W
-
G
F
A
-----
A
I
------
S
F
G
Y
--
L
Q
I
-
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
---------------
P
A
-
L
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
---
L
T
Q
-----
F
G
----
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
----
F
I
--
L
I
-
A
L
A
A
-------
I
-
Y
--
L
H
T
----
F
F
---
P
----
D
F
--
S
K
V
G
T
--
L
V
-
V
F
-
V
A
F
I
L
S
Y
M
----
G
V
E
A
S
A
T
H
V
N
--------
E
M
S
N
P
G
R
D
Y
P
L
A
-
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
--
G
L
S
I
A
---
M
V
I
P
G
N
---------------
E
-
I
N
-------------------------------
L
S
A
G
------------------------
V
M
Q
T
F
T
V
L
M
S
H
V
A
P
-
E
-
I
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
-----------
A
E
I
A
S
W
I
-------------------------------------------------
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
-
P
-
A
A
F
A
K
M
-----
N
K
---------------------------
N
G
V
P
---
V
T
L
V
I
S
Q
---------
L
V
I
T
S
I
A
L
I
I
L
T
---
N
T
G
G
G
-------
N
N
-----------
M
S
F
L
I
A
L
A
L
-----------
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
-----------
G
K
G
V
K
L
V
V
-------------
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
-----
L
H
P
R
A
R
S
P
-----------------------------------------------------
14
PsiBlast_PDB
50.52
22%
-142
- C3 -
4DJK
-
GADC_ECOLI
A:
[132-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
L
I
I
L
W
A
L
A
L
T
---
Q
F
G
GTKY
T
A
R
I
A
K
V
--
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
----
Y
L
H---------------------------
T
F
---
F
----
P
---
D
F
S
K
V
-----
G
T
-
L
V
V
F
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
--------
E
M
S
N
P
G
R
D
Y
P
L
A
-
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
--
G
L
S
I
A
---
M
V
I
P
G
N
---------------
E
-
I
N
--
L
S
-
A
G
V
M
Q
T
F
T
V
L
M
SH
V
A
P
E
I
E
W
T
-
V
R
-
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
---
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
-
M
-
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
-----------
T
S
I
A
L
I
I
-------
L
T
N
T
G
G
G
N
N
----
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
-
G
-
V
K
L
V
V
A
-----
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
-----
P
P
D
N
I
Q
G
D
S
T
D
M
---
Y
V
E
L
L
V
V
---------
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
--
R
A
R
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
48.95
22%
-141
- C3 -
4DJI
-
GADC_ECOLI
A:
[132-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
A
L
I
I
L
W
A
L
A
L
T
---
Q
F
G
GTKY
T
A
R
I
A
K
V
--
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
I
----
Y
L
HS
G
----
A
I
-------
E
-
M
--
D
S
K
----
T
F
---
F
----
P
---
D
F
S
K
V
-----
G
T
-
L
V
V
F
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
--------
E
M
S
N
P
G
R
D
Y
P
L
A
-
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
--
G
L
S
I
A
---
M
V
I
P
G
N
---------------
E
-
I
N
--
L
S
-
A
G
V
M
Q
T
F
T
V
L
M
S
H
V
A
P
E
I
E
W
T
-
V
R
-
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
---
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
-
M
-
N
-
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
-----------
T
S
I
A
L
I
I
-------
L
T
N
T
G
G
G
N
N
----
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
T
F
N
I
P
G
G
K
-
G
-
V
K
L
V
V
A
-----
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
-----
P
P
D
N
I
Q
G
D
S
T
D
M
---
Y
V
E
L
L
V
V
---------
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
D
A
N
T
G
--
V
T
L
E
P
I
-----------
N
S
Q
N
A
P
K
G
H
-----------
F
F
L
H
P
R
A
R
S
P
H
Y
I
V
M
N
D
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
38.54
13%
-85
- C3 -
3DH4
1
?
A:
[53-355]
------------------------------------------------
G
K
S
L
P
W
W
A
V
G
-
A
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
-
S
I
G
L
A
I
A
-------
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
---
I
F
I
E
K
-
G
I
Y
T
I
P
--------------
E
F
V
E
K
R
F
N
K
----------
K
L
-
K
T
I
-----
L
A
------
V
F
W
I
--
S
L
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
P
--
L
--------
M
----------
Y
S
I
L
G
L
A
L
F
A
L
V
Y
S
I
--------------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
----
S
F
--
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
--
A
P
G
----
H
F
EMI
L
DQSN
P
Q
YM
N
L
P
G
I
AV
L
I
G
G
L
W
V
A
N
L
Y
Y
W
G
----
F
N
Q
Y
I
I
Q
R
T
L
--------
A
A
K
S
V
-
S
E
A
Q
K
G
-
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
--
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
A
S
L
GDIAATNLP
S
A
A
N
--
A
D
-
K
A
Y
P
W
L
T
-------
Q
F
L
P
V
G
V
-
K
G
-
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
---
L
N
S
T
A
T
I
F
T
---
M
D
I
Y
K
E
Y
I
S
P
D
-
S
-
G
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
-----------
I
I
A
C
L
I
A
-------
P
M
L
G
G
I
G
Q
A
----
F
Q
Y
I
Q
E
Y
T
G
L
V
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
A
L
-
F
-
L
K
F
M
P
L
-----
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
-----
V
V
I
A
F
T
S
L
S
T
S
I
---
N
D
D
D
P
K
G
---------
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
--
M
I
V
L
A
V
-----------
L
Y
T
L
F
W
V
L
Y
-----------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
34.04
32%
-7
- C3 -
4C1L
-
?
A:
[207-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
---
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
-----
V
-
H
P
E
P
E
K
A
L
S
D
S
Q
Q
Q
L
T
F
-----------
D
D
F
L
Q
L
L
-------
K
E
L
E
A
L
G
W
K
----
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
33.85
32%
-13
- C3 -
4C1K
1
?
A:
[207-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
---
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
-----
V
-
H
P
E
P
E
K
A
L
S
D
S
Q
Q
Q
L
T
F
-----------
D
D
F
L
Q
L
L
-------
K
E
L
E
A
L
G
W
K
----
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
32.39
25%
580
- C3 -
4UI9
-
?
U:
[1-24]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
R
R
P
C
S
C
A
L
R
P
P
-----
A
A
A
A
A
A
A
A
A
A
A
--------------------------------------------------