@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0767: (2014-05-07 )
MLKKAKLILIAVLVLSGCSTIENESKKDRNTETNTETKSVPEEMEASKYVGQGFQPPAEKDAIEFSKKHKDKIAKRGEQFFMDNFGLKVKATNVVGSGDGVEVFVHCDDHDIVFNASIPFDKSIIESDSSLRSEDKGDDMSTLVGTVLSGFEYRAHKEELDNLTEVLKEYKSKYKYTGYTENAIMKTQNSGFRNEYYYLTAIPYTLDEYKRYFQPLIKEDDKSFRDGMRNSKKQLKDKSRPYVVTTLFSTKDNFTKDNTIDEMIDFSEVLKKKKNIPHDLNVSLQISNKYINTKRPNYSKKEVIEVGVFNHEKANTND
Atome Classification :
(20 SA)
---------------------------------------------------------------------------.........10........20........30.......----.40........50........60...--------------------.....70........80...-----------------.--....90.-......-.100.-......-..--110.......120.....-..130-.........140......---.----150.......160...---....170--------.......180.......190.......-----------200.......-----210.......220.......230........-240.......250.......260.......270.....-----..-280----------....-....290.....--..300......----...310......------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------MLKK
A
K
L
I
L
I
A
V
L
V
L
SGCSTIENESKKDRNTETNTETK----S
V
P
E
E
M
E
A
S
K
YVGQGFQPPA
E
K
D
A
I
E
--------------------
F
S
K
K
H
K
D
K
I
A
K
R
G
E
Q
F
F
M
DN-----------------F--G
L
K
V
K
A
T
-
N
V
VGSG-D
G
--
V
-
E
V
F
V
H
C-DD--H
D
I
V
F
NASIPF
D
K
S
I
I
ES-DSS---LRSEDKGD
D
M
S
T
L
V
G
T
V
L
---
S
----GFEY
R
A
H
K
E
E
L
D
N
L
T
E
---
V
L
K
E
Y
K
S
--------KYKYTGYTEN
A
I
M
KTQNSGFR
N
E
Y
Y
Y
L
-----------
T
AIPY
T
L
D
E
Y
-----
K
R
Y
F
Q
P
L
I
KED
D
K
S
F
R
D
G
M
R
N
S
-
K
K
Q
LKDKS-R
P
Y
V
V
T
T
L
FSTKDNFTKDN
T
I
D
E
M
I
D
F
S
E
V
L
K
K
KKNIP-----HD-
L
N
-----------
V
S
L
Q
-ISNKYINTKRPN--YS
K
--
K
E
V
I
E
V
----
G
V
FNHEKANTND------------
4
Fugue
85.97
14%
13
- C1 -
2W45
-
AN_EBVB9
A:
[7-466]
LEDPMEEMTSYT
F
A
R
F
L
R
S
P
E
T
E
A
F
V
R
N
LDRPPQM
P
A
M
R
F
V
Y
L
Y
C
L
C
K
Q
I
Q
E
FSGET
G
F
C
D
F
V
S
S
L
V
QEDGPS
L
K
S
I
Y
W
G
L
Q
E
A
T
D
E
Q
R
T
V
L
C
S
Y
V
E
S
M
T
R
G
Q
S
E
N
L
M
W
D
I
L
R
NGII
S
S
S
K
L
L
S
T
I
K
N
G
P
T
K
V
F
E
P
A
F
G
G
P
V
A
--------------------
F
G
L
R
C
E
D
T
V
K
D
I
V
C
K
L
I
C
G
D
ASANRQFGFMISPTDGI
F
--
G
V
S
L
D
L
C
V
N
V
E
S
Q
G
-
D
F
--
I
-
L
F
T
D
R
S
-
C
I
--
Y
E
I
K
C
R
F
K
Y
L
F
S
K
S
E
F
D
P
I
Y
P
S
---
Y
T
A
L
Y
K
R
P
C
K
R
S
F
I
R
F
I
N
---
S
IARP
T
V
E
Y
V
P
D
G
R
L
P
S
E
G
D
Y
---
L
L
T
Q
D
E
A
WNLKDVRK
R
K
L
G
P
G
H
D
L
V
A
D
S
L
A
A
N
R
G
V
E
S
M
L
Y
V
M
T
DPSENAGRIG
I
K
D
R
V
P
V
N
I
F
I
N
PRH
N
Y
F
Y
Q
V
L
L
Q
Y
K
I
V
G
D
Y
V
R
H
S
G
G
-
G
K
P
G
R
D
C
S
P
R
V
N
I
V
T
A
F
F
R
K
R
S
P
L
D
P
A
T
C
---
T
L
G
S
D
L
L
L
D
A
S
V
E
I
P
V
A
V
L
V
T
P
-
V
V
-----------
L
P
D
S
-
V
I
R
K
T
L
S
T
A
A
G
S
--
W
K
A
Y
A
D
N
T
F
D
T
----
A
P
W
V
P
S
G
L
F
A
D
D
------------
9
Fugue
75.36
11%
28
- C1 -
2I0Z
1
?
A:
[25-444]
------------MHYD
V
I
V
I
G
GG
P
S
G
L
M
A
A
I
G
A
A
E
E
GAN
V
L
L
L
D
KGNKLG
R
K
L
A
I
SGGGRCNVTNRLP
L
D
E
I
V
K
H
I
P
G
N
G
R
F
L
Y
S
A
F
S
I
F
N
N
E
D
I
I
T
F
F
E
N
L
G
V
K
L
K
E
E
D
H
G
R
----
M
F
P
V
S
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
G
V
K
I
--------------------
R
T
N
T
P
V
E
T
I
E
Y
E
N
G
Q
T
K
A
V
I
-----------------
L
QT
G
E
V
L
E
T
N
-
H
V
V
I
A
V
-
G
G
----
K
S
V
P
Q
T
-
G
S
--
T
G
D
G
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
-
F
P
T
E
V
P
I
L
S
N
E
P
F
I
R
D
R
S
L
Q
G
L
A
L
---
R
----
D
I
N
L
S
V
L
N
A
I
I
S
H
K
M
D
---
M
L
F
T
H
F
G
--------
L
S
G
P
A
A
L
R
C
S
Q
F
V
V
K
A
L
K
K
F
K
T
N
T
I
Q
M
-----------
S
I
D
A
L
P
E
E
N
S
-----
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
P
K
K
G
I
K
N
V
L
K
G
Y
V
P
E
R
Y
-
F
L
F
L
L
E
K
N
E
I
D
G
S
E
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
-----
N
G
-
T
Q
SIEKAFVTGGG
V
S
V
K
E
I
N
P
K
E
M
S
S
K
F
T
N
G
L
Y
F
C
--
G
E
V
L
D
I
H
G
Y
T
G
G
Y
N
I
T
S
A
L
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K
33
HHSearch
52.62
16%
-106
- C1 -
3J39
-
RL22_DROME
U:
[212-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
I
K
A
R
-----------------
L
--
K
V
N
G
K
V
N
-
N
L
---
G
-
N
N
-----
V
T
F
E
R
-
S
K
--
L
K
L
I
V
S
S
D
V
H
F
S
K
A
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
Fugue
50.42
12%
37
- C1 -
3KYQ
1
YKT6_RAT
A:
[1-193]
------------------------------------------------------------------------------
L
M
K
L
Y
S
L
S
V
F
Y
K
G
E
P
K
A
V
L
L
K
A
A
Y
D
V
S
S
F
S
F
F
Q
R
S
----
S
V
Q
E
F
M
T
F
T
S
Q
L
I
V
E
R
S
A
K
G
S
R
A
S
V
K
E
Q
E
Y
L
C
H
V
Y
V
R
SDS
L
A
G
V
V
I
A
D
S
E
Y
P
S
R
V
A
F
T
L
L
E
K
V
L
D
E
-----------------
F
--
S
K
Q
V
D
R
I
-
D
W
P
V
G
S
-
P
A
--
T
-
I
H
Y
T
A
L
-
D
G
--
H
L
S
R
Y
Q
N
--
P
R
E
A
D
P
M
S
K
-
V
Q
A
---
E
L
D
E
T
K
I
I
L
H
N
T
M
E
S
L
L
E
---
R
----
G
E
K
L
D
D
L
V
S
K
S
E
V
L
G
T
---
Q
S
K
A
F
Y
K
--------
T
A
R
K
Q
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
49.59
10%
-60
- C1 -
2P25
-
?
A:
[17-58]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
T
K
N
F
Y
V
E
K
-----------------
L
--
G
F
E
V
L
R
E
-
N
H
R
P
E
K
-
N
D
--
I
-
K
L
D
L
K
L
-
G
S
--
Q
E
L
E
I
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
Fugue
49.41
15%
2
- C1 -
2KKU
-
?
A:
[1-139]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
K
I
V
G
V
T
Y
PIP
K
----
R
F
M
D
R
F
F
K
K
G
K
D
V
F
V
K
PAT
V
W
K
E
L
K
P
--------
G
M
K
F
V
F
Y
Q
S
H
E
D
T
G
F
V
G
E
A
R
I
K
R
V
V
L
S
-----------
E
N
P
M
Q
F
F
E
T
F
-----
G
D
R
V
F
L
T
K
D
E
L
K
E
Y
M
K
S
Q
E
R
W
G
-
R
R
R
E
S
K
K
K
-
K
L
W
M
A
I
E
L
E
D
V
K
K
Y
D
K
P
I
K
P
K
R
L
V
P
V
G
G
Q
Y
L
R
E
------------------------------------------------------------------------------------
45
HHSearch
48.93
13%
-37
* C1 *
3LM4
2
?
A:
[166-207]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
D
S
F
E
R
H
-----------------
L
--
G
F
R
T
T
E
R
-
V
V
D
G
N
--
V
E
--
I
-
G
A
W
M
S
S
-
N
L
LG
H
E
V
A
C
M
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
47.76
23%
-43
- C1 -
4GHG
-
?
A:
[165-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
R
K
Y
L
E
D
------------------
L
--
G
F
R
V
T
E
D
-
I
Q
D
D
E
G
-
T
T
--
Y
-
A
A
W
M
H
R
-
K
G
TV
H
D
T
A
L
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
46.60
28%
-56
- C1 -
3J3B
-
RL22_HUMAN
U:
[40-82]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
F
L
Q
E
R
-----------------
I
--
K
V
N
G
K
A
G
-
N
----
L
-
G
G
--
G
-
V
V
T
I
E
R
-
S
K
--
S
K
I
T
V
T
S
E
V
P
F
S
K
R
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
46.12
25%
-114
- C1 -
4A18
-
RL22_TETTS
M:
[35-78]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
E
F
L
K
S
K
-----------------
I
--
K
V
G
G
K
L
G
-
N
L
---
G
-
E
N
-----
I
T
I
S
N
-
D
D
--
K
K
I
N
V
Q
S
T
I
P
F
S
K
R
Y
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
45.88
33%
-38
- C1 -
3B59
-
?
A:
[154-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
V
K
F
F
T
D
V
-----------------
L
--
G
F
K
V
S
D
W
-
L
----
G
-
D
F
----
M
C
F
L
R
C
-
N
S
AH
H
R
I
A
I
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
45.54
17%
-113
- C1 -
4BYN
-
RL22A_YEAST
U:
[33-74]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Y
L
I
D
H
-----------------
I
--
K
V
E
G
A
V
G
-
N
L
---
G
-
N
A
-----
V
T
V
T
E
-
D
G
--
T
V
V
T
V
V
S
T
A
K
F
S
G
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
45.25
27%
-33
- C1 -
1F1U
-
?
A:
[165-205]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
R
A
Y
L
E
D
------------------
L
--
G
F
R
V
S
E
D
-
I
--
K
D
S
-
D
G
VT
Y
-
A
A
W
M
H
R
-
K
Q
TV
H
D
T
A
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
44.67
14%
-54
- C1 -
3L7T
-
?
A:
[17-58]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
S
Y
E
F
Y
V
N
Q
-----------------
L
--
G
F
E
V
I
R
E
-
N
H
R
P
K
R
-
H
D
--
Y
-
K
L
D
L
K
C
-
G
D
--
I
E
L
E
I
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
44.13
31%
-51
- C1 -
1ZT2
-
PRIS_SULSO
A:
[144-186]
-------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
K
--------------------
R
G
L
E
Q
T
R
N
L
V
----
E
I
L
E
D
D
-----------------
F
--
G
L
K
P
----
K
V
Y
F
S
G
N
R
G
--
F
-
H
V
Q
V
D
C
-
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
43.57
19%
-74
- C1 -
3ZF7
-
?
V:
[47-89]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
Q
Y
F
Q
D
N
-----------------
V
--
K
L
N
G
R
K
G
-
K
L
---
T
-
S
K
-----
V
R
V
N
M
-
R
E
--
N
T
L
S
I
T
T
T
M
A
Y
R
K
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
41.18
20%
-47
- C1 -
1MPY
1
XYLE1_PSEPU
A:
[162-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
Y
D
L
F
T
K
V
-----------------
L
--
G
F
Y
L
A
E
Q
-
V
L
D
E
N
G
-
T
R
--
V
-
A
Q
F
L
S
L
-
S
T
KA
H
D
V
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
39.05
17%
-45
- C1 -
3E5D
-
?
A:
[15-58]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
M
K
Q
F
Y
V
T
Y
-----------------
F
--
G
A
T
A
N
D
L
-
Y
E
N
K
-
T
-
K
G
--
F
N
S
Y
F
L
S
F
E
D
G
--
A
R
L
E
I
M
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
37.39
30%
72
- C1 -
2RDC
1
?
A:
[75-130]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
R
E
L
T
E
T
L
D
R
S
R
R
L
A
-----
H
E
S
L
I
-----------
S
S
L
H
-
V
F
N
R
Y
I
V
K
E
Y
G
E
--
E
L
K
--
E
A
G
I
E
G
----
G
I
F
P
K
P
E
A
N
---------------
49
HHSearch
35.85
14%
-17
- C1 -
1QTO
-
?
A:
[17-51]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
N
V
S
F
W
V
D
T
-----------------
L
--
G
F
E
K
D
F
G
-
D
------
R
D
----
F
A
G
V
R
R
-
G
D
--
I
R
L
H
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
User Run . : Multi Template Modeling Result:
(3 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLKK
A
K
L
I
L
I
A
V
L
V
L
SGCSTIENESKKDRNTETNTETKS
V
P
E
E
M
E
A
S
K
YVGQGFQPPA
E
K
D
A
I
E
F
S
K
K
H
K
D
K
I
A
K
R
G
E
Q
F
F
M
DNFG
L
K
V
K
A
T
N
V
VGSGD
G
V
E
V
F
V
H
CDDH
D
I
V
F
NASIPF
D
K
S
I
I
ESDSSLRSEDKGD
D
M
S
T
L
V
G
T
V
L
S
GFEY
R
A
H
K
E
E
L
D
N
L
T
E
V
L
K
E
Y
K
S
KYKYTGYTEN
A
I
M
KTQNSGFR
N
E
Y
Y
Y
L
T
AIPY
T
L
D
E
Y
K
R
Y
F
Q
P
L
I
KED
D
K
S
F
R
D
G
M
R
N
S
K
K
Q
LKDKSR
P
Y
V
V
T
T
L
FSTKDNFTKDN
T
I
D
E
M
I
D
F
S
E
V
L
K
K
KKNIPHD
L
N
V
S
L
Q
ISNKYINTKRPNYS
K
K
E
V
I
E
V
G
V
FNHEKANTND
66
82.59
100%
27
- C- -
M066
-
A:
[1-496]
M
L
K
K
A
K
L
I
L
I
A
V
L
V
L
S
G
C
S
T
I
E
N
E
S
K
K
D
R
N
T
E
T
N
T
E
T
K
S
V
P
E
E
M
E
A
S
K
Y
V
G
Q
G
F
Q
P
P
A
E
K
D
A
I
E
F
S
K
K
H
K
D
K
I
A
K
R
G
E
Q
F
F
M
D
N
F
G
L
K
V
K
A
T
N
V
V
G
S
G
D
G
V
E
V
F
V
H
C
D
D
H
D
I
V
F
N
A
S
I
P
F
D
K
S
I
I
E
S
D
S
S
L
R
S
E
D
K
G
D
D
M
S
T
L
V
G
T
V
L
S
G
F
E
Y
R
A
H
K
E
E
L
D
N
L
T
E
V
L
K
E
Y
K
S
K
Y
K
Y
T
G
Y
T
E
N
A
I
M
K
T
Q
N
S
G
F
R
N
E
Y
Y
Y
L
T
A
I
P
Y
T
L
D
E
Y
K
R
Y
F
Q
P
L
I
K
E
D
D
K
S
F
R
D
G
M
R
N
S
K
K
Q
L
K
D
K
S
R
P
Y
V
V
T
T
L
F
S
T
K
D
N
F
T
K
D
N
T
I
D
E
M
I
D
F
S
E
V
L
K
K
K
K
N
I
P
H
D
L
N
V
S
L
Q
I
S
N
K
Y
I
N
T
K
R
P
N
Y
S
K
K
E
V
I
E
V
G
V
F
N
H
E
K
A
N
T
N
D
68
79.15
100%
18
- C- -
M068
-
A:
[1-476]
M
L
K
K
A
K
L
I
L
I
A
V
L
V
L
S
G
C
S
T
I
E
N
E
S
K
K
D
R
N
T
E
T
N
T
E
T
K
S
V
P
E
E
M
E
A
S
K
Y
V
G
Q
G
F
Q
P
P
A
E
K
D
A
I
E
F
S
K
K
H
K
D
K
I
A
K
R
G
E
Q
F
F
M
D
N
F
G
L
K
V
K
A
T
N
V
V
G
S
G
D
G
V
E
V
F
V
H
C
D
D
H
D
I
V
F
N
A
S
I
P
F
D
K
S
I
I
E
S
D
S
S
L
R
S
E
D
K
G
D
D
M
S
T
L
V
G
T
V
L
S
G
F
E
Y
R
A
H
K
E
E
L
D
N
L
T
E
V
L
K
E
Y
K
S
K
Y
K
Y
T
G
Y
T
E
N
A
I
M
K
T
Q
N
S
G
F
R
N
E
Y
Y
Y
L
T
A
I
P
Y
T
L
D
E
Y
K
R
Y
F
Q
P
L
I
K
E
D
D
K
S
F
R
D
G
M
R
N
S
K
K
Q
L
K
D
K
S
R
P
Y
V
V
T
T
L
F
S
T
K
D
N
F
T
K
D
N
T
I
D
E
M
I
D
F
S
E
V
L
K
K
K
K
N
I
P
H
D
L
N
V
S
L
Q
I
S
N
K
Y
I
N
T
K
R
P
N
Y
S
K
K
E
V
I
E
V
G
V
F
N
H
E
K
A
N
T
N
D
65
77.58
100%
31
- C- -
M065
-
A:
[1-476]
M
L
K
K
A
K
L
I
L
I
A
V
L
V
L
S
G
C
S
T
I
E
N
E
S
K
K
D
R
N
T
E
T
N
T
E
T
K
S
V
P
E
E
M
E
A
S
K
Y
V
G
Q
G
F
Q
P
P
A
E
K
D
A
I
E
F
S
K
K
H
K
D
K
I
A
K
R
G
E
Q
F
F
M
D
N
F
G
L
K
V
K
A
T
N
V
V
G
S
G
D
G
V
E
V
F
V
H
C
D
D
H
D
I
V
F
N
A
S
I
P
F
D
K
S
I
I
E
S
D
S
S
L
R
S
E
D
K
G
D
D
M
S
T
L
V
G
T
V
L
S
G
F
E
Y
R
A
H
K
E
E
L
D
N
L
T
E
V
L
K
E
Y
K
S
K
Y
K
Y
T
G
Y
T
E
N
A
I
M
K
T
Q
N
S
G
F
R
N
E
Y
Y
Y
L
T
A
I
P
Y
T
L
D
E
Y
K
R
Y
F
Q
P
L
I
K
E
D
D
K
S
F
R
D
G
M
R
N
S
K
K
Q
L
K
D
K
S
R
P
Y
V
V
T
T
L
F
S
T
K
D
N
F
T
K
D
N
T
I
D
E
M
I
D
F
S
E
V
L
K
K
K
K
N
I
P
H
D
L
N
V
S
L
Q
I
S
N
K
Y
I
N
T
K
R
P
N
Y
S
K
K
E
V
I
E
V
G
V
F
N
H
E
K
A
N
T
N
D