@tome V2.1
Ref.
-
-
Doc.
Global output mode :
Group entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Selected Ligands Contact
Catalytic Site Atlas
Show alignment :
Best alignments
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
Structural Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Modeller Score
Verify3D Model Score
QMean Model Score
Hide column
Complexes Prediction
Show Ligands of Templates
Comparative Docking Score
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Comparative Docking Tab
Atome Color :
Mutated
Helix
Strand
Conserved
Query sequence : >T0692: (2012-05-29 )
MTKTIEVRNPRTGKFDYVIIPPPPRLLAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGRLSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRDVLIFVEGGGETGANLINYVDFVCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEKNAFNFSGLGGSRVGAAGLKRFLRKQAFLIKTNSTSDPWWFDKGD
Atome Classification :
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------MTKTIEVRNP-R-TGKFDYVIIPPPPRLLAQQCNRA----RRAQ---S-----R--WQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGR--L--------SIT-V--L--E-ID-SFLASIDRWCGLAPELLQTSAKNTS---IPF---IALQQSLVPYP--LVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRF-VAPLLMALNT----VPELRDVLIFVEGGG-E-T-GANLI---N--Y--VDFVCFTGSVATGREVAETAA------R-RFI-PAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVE-DGAIGPIIAEKQAGIINDHILDAVEKG-A-VIHCGGKV--EE-------L--GGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPD--VEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMH-EGEKNAFNFSGLGG-SRVG-AAGLKRFLRKQAFLIKTNSTSDPW-WFDKGD
41
HHSearch
98.20
31%
-90.77
- C5 -
3ED6
2
?
A:
[47-520]
----------------------------
K
N
T
R
D
I
I
N
P
-
Y
-
N
Q
E
V
I
F
T
V
S
E
G
T
K
E
D
A
E
R
A
I
L
A
A
----
R
R
A
F
---
E
-----
S
GE
W
S
Q
E
T
A
E
T
R
G
K
K
V
R
A
I
A
D
K
I
K
E
H
R
E
A
L
A
R
L
E
T
L
D
T
G
K
--
T
--------
L
E
E
-
S
Y
-
A
--
D
-
M
D
-
D
I
H
N
V
F
M
Y
F
A
G
L
A
D
K
D
-
G
G
E
M
I
D
S
P
---
I
P
D
---
T
E
S
K
I
V
K
E
P
V
G
--
V
V
T
Q
I
T
P
W
N
Y
P
L
L
Q
A
S
W
K
I
A
P
A
L
A
T
G
C
S
L
V
M
K
P
S
E
I
T
P
L
T
-
T
I
R
V
F
E
L
M
E
E
----
V
G
F
P
K
G
T
I
N
L
I
L
G
A
G
S
E
-
V
-
G
D
V
M
S
---
G
--
H
KE
V
D
L
V
S
F
T
G
G
I
E
T
G
K
H
I
M
K
N
A
A
------
N
-
N
V
T
-
N
I
A
L
E
L
G
G
K
N
P
N
I
I
F
D
D
A
D
F
E
L
A
V
D
Q
A
L
N
G
G
Y
F
H
A
G
Q
V
C
S
A
G
S
R
I
L
V
Q
N
S
I
K
D
K
F
E
Q
A
L
I
D
R
V
K
K
I
K
L
G
N
G
F
D
A
-
D
T
E
M
G
P
V
I
S
T
E
H
R
N
K
I
E
S
Y
M
D
V
A
K
A
E
G
-
A
-
T
I
A
V
G
G
K
R
--
P
D
RDD----
L
--
K
D
G
L
F
F
E
P
T
V
I
T
N
C
D
T
S
M
R
I
V
Q
E
E
V
F
G
P
V
V
T
V
E
G
F
E
T
--
E
Q
E
A
I
Q
L
A
N
D
S
I
Y
G
L
A
G
A
V
F
S
K
D
I
G
K
A
Q
R
V
A
N
K
L
K
L
G
T
V
W
I
N
D
F
H
P
--
Y
F
A
-
Q
A
P
W
G
G
Y
K
Q
S
G
I
-
G
-
R
E
L
G
-
K
E
G
L
E
E
Y
L
V
S
K
H
I
L
T
N
T
N
-
P
Q
L
V
N
-
W
F
S
K
--
56
HHSearch
97.93
31%
-92.52
- C5 -
3IWJ
6
?
A:
[23-500]
-----------------------------
K
R
I
P
V
I
N
P
-
A
-
T
Q
N
I
I
G
D
I
P
A
A
T
K
E
D
V
D
V
A
V
A
A
A
----
K
T
A
L
---
T
RNKGA
D
--
W
A
T
A
S
G
A
V
R
A
R
Y
L
R
A
I
A
A
K
V
T
E
K
K
P
E
L
A
K
L
E
S
I
D
C
G
K
--
P
--------
L
D
E
-
A
A
-
W
--
D
-
I
D
-
D
V
A
G
C
F
E
Y
Y
A
D
L
A
E
K
L
D
A
R
-
Q
K
A
P
V
S
L
P
M
D
T
---
F
K
S
H
V
L
R
E
P
I
G
--
V
V
G
L
I
T
P
W
N
Y
P
M
L
M
A
T
W
K
V
A
P
A
L
A
A
G
C
A
A
I
L
K
P
S
E
L
A
S
L
T
-
C
L
E
L
G
E
I
C
K
E
----
V
G
L
P
P
G
V
L
N
I
L
T
G
L
G
P
E
-
A
-
G
A
P
L
A
---
T
--
H
PD
V
D
K
V
A
F
T
G
S
S
A
T
G
S
K
I
M
T
A
A
A
------
Q
-
L
V
K
-
P
V
S
L
E
L
G
G
K
S
P
L
V
V
F
E
D
V
D
L
D
K
A
A
E
W
A
I
F
G
C
F
W
T
N
G
Q
I
C
S
A
T
S
R
L
I
L
H
E
S
I
A
T
E
F
L
N
R
I
V
K
W
I
K
N
I
K
I
S
D
P
L
E
E
-
G
C
R
L
G
P
V
V
S
E
G
Q
Y
E
K
I
L
K
F
V
S
N
A
K
S
E
G
-
A
-
T
I
L
T
G
G
S
R
--
P
E
H------
L
--
K
K
G
F
F
I
E
P
T
I
I
T
D
V
T
T
N
M
Q
I
W
R
E
E
V
F
G
P
V
L
C
V
K
T
F
S
T
--
E
E
E
A
I
D
L
A
N
D
T
V
Y
G
L
G
A
A
V
I
S
N
D
L
E
R
C
E
R
V
T
K
A
F
K
A
G
I
V
W
V
N
C
S
Q
P
--
C
F
T
-
Q
A
P
W
G
G
V
K
R
S
G
F
-
G
-
R
E
L
G
-
E
W
G
L
D
N
Y
L
S
V
K
Q
V
T
Q
--
Y
I
S
E
E
P
W
G
W
Y
Q
P
P
-
45
HHSearch
96.52
29%
-91.63
- C5 -
1BXS
1
AL1A1_SHEEP
A:
[35-498]
----------------------------
G
K
K
F
P
V
F
N
P
-
A
-
T
E
E
K
L
C
E
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
----
R
Q
A
F
---
Q
IGS--
P
--
W
R
T
M
D
A
S
E
R
G
R
L
L
N
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
A
M
N
G
G
K
--
L
--------
F
S
N
-
A
--
Y
L-
M
D
L
G
-
G
C
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
-
G
R
T
I
P
M
D
----
G
N
---
F
F
T
Y
T
R
S
E
P
V
G
--
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
L
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
-
A
L
H
M
G
S
L
I
K
E
----
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
-
A
-
G
A
A
I
S
---
S
--
H
MD
V
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
G
------
K
S
N
L
K
-
R
V
S
L
E
L
G
G
K
S
P
C
I
V
F
A
D
A
D
L
D
N
A
V
E
F
A
H
Q
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
L
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
V
L
G
N
P
L
T
P
-
G
V
S
Q
G
P
Q
I
D
K
E
Q
Y
E
K
I
L
D
L
I
E
S
G
K
K
E
G
-
A
-
K
L
E
C
G
G
G
P
--
W
G
----------
N
K
G
Y
F
I
Q
P
T
V
F
S
D
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
--
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
I
F
T
N
D
I
D
K
A
I
T
V
S
S
A
L
Q
S
G
T
V
W
V
N
C
Y
S
--
V
V
S
A
-
Q
C
P
F
G
G
F
K
M
S
G
N
-
G
-
R
E
L
G
-
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
I
K
I
S
Q
------------
40
HHSearch
96.07
28%
-89.95
- C5 -
2D4E
2
?
A:
[41-513]
----------------------------
G
E
T
F
P
S
L
D
P
-
A
-
T
N
E
V
L
G
V
A
A
R
G
G
E
R
E
V
D
R
A
A
K
A
A
----
H
E
A
F
---
Q
-----
R
--
W
S
R
T
K
A
K
E
R
K
R
Y
L
L
R
I
A
E
L
I
E
K
H
A
D
E
L
A
V
M
E
C
L
D
A
G
Q
--
V
--------
L
R
I
V
R
--
A
--
Q
-
V
A
-
R
A
A
E
N
F
A
F
Y
A
E
Y
A
E
H
A
M
E
D
R
T
F
P
V
D
----
R
D
---
W
L
Y
Y
T
V
R
V
P
A
G
--
P
V
G
I
I
T
P
W
N
A
P
L
M
L
S
T
W
R
I
A
P
A
L
A
F
G
N
T
V
V
L
K
P
A
E
W
S
P
F
T
-
A
T
K
L
A
E
I
L
K
E
----
A
D
L
P
P
G
V
F
N
L
V
Q
G
F
G
E
E
-
A
-
G
A
A
L
V
---
A
--
H
PL
V
P
L
L
T
L
T
G
E
T
E
T
G
K
I
V
M
R
N
A
A
------
D
-
H
L
K
-
R
L
S
P
E
L
G
G
K
S
P
A
L
V
F
A
D
A
D
L
E
R
A
L
D
A
V
V
F
Q
I
F
S
F
N
G
E
R
C
T
A
S
S
R
L
L
V
E
E
K
I
F
E
D
F
V
G
K
V
V
E
R
A
R
A
I
R
V
G
H
P
L
D
P
-
E
T
E
V
G
P
L
I
H
P
E
H
L
Q
R
V
L
G
Y
V
E
A
G
K
R
E
G
-
A
-
R
L
L
V
G
G
E
R
--
A
K
TSFRGED
L
--
S
R
G
N
Y
L
L
P
T
V
F
V
G
E
N
-
H
M
K
I
A
Q
E
E
I
F
G
P
V
L
V
A
I
P
F
K
D
--
E
E
E
A
L
R
K
A
N
D
T
K
Y
G
L
A
A
Y
V
F
T
R
D
L
E
R
A
H
R
L
A
L
E
L
E
A
G
M
V
Y
L
N
S
H
N
V
--
R
H
L
-
P
T
P
F
G
G
V
K
G
S
G
D
-
R
-
R
E
G
G
-
T
Y
A
L
D
F
Y
T
D
L
K
T
I
A
L
P
L
R
P
P
H
V
P
K
-
F
-----
21
Fugue
95.94
28%
-90.62
- C5 -
1BXS
1
AL1A1_SHEEP
A:
[8-501]
DV
P
A
P
L
T
N
L
Q
F
K
YT
K
I
F
I
NN
E
W
H
S
SVS
G
-
K
K
F
P
V
F
N
P
-
A
-
T
E
E
K
L
C
E
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
----
R
Q
A
F
QIG
S
-----
P
--
W
R
T
M
D
A
S
E
R
G
R
L
L
N
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
A
M
N
G
G
K
L
F
S
--------
N
A
Y
-
L
--
M
--
D
-
L
G
-
G
C
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
-
Q
G
R
T
I
P
M
D
---------
G
N
F
F
T
Y
T
R
S
E
P
V
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
L
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
-
A
L
H
M
G
S
L
I
K
E
----
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
-
P
-
T
-
A
G
A
A
I
S
S
H
M
--
D
--
V
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
G
------
K
-
S
N
L
K
R
V
S
L
E
L
G
G
K
S
P
C
I
V
F
A
D
A
D
L
D
N
A
V
E
F
A
H
Q
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
L
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
V
L
G
N
P
L
T
P
-
G
V
S
Q
G
P
Q
I
D
K
E
Q
Y
E
K
I
L
D
L
I
E
S
G
K
K
E
G
-
A
-
K
L
E
C
G
G
G
P
W
G
------------
N
K
G
Y
F
I
Q
P
T
V
F
S
D
V
T
D
D
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
--
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
I
F
T
N
D
I
D
K
A
I
T
V
S
S
A
L
Q
S
G
T
V
W
V
N
C
Y
S
V
--
V
S
A
-
Q
C
P
F
G
G
F
K
M
S
G
N
G
R
-
E
L
-
G
-
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
I
K
-
I
S
Q
K
N
S
--------
39
HHSearch
95.55
28%
-93.90
- C5 -
1A4S
-
BADH_GADCA
A:
[36-499]
-----------------------------
T
T
E
P
V
F
E
P
-
A
-
T
G
R
V
L
C
Q
M
V
P
C
G
A
E
E
V
D
Q
A
V
Q
S
A
----
Q
A
A
Y
---
L
-----
K
--
W
S
K
M
A
G
I
E
R
S
R
V
M
L
E
A
A
R
I
I
R
E
R
R
D
N
I
A
K
L
E
V
I
N
N
G
K
--
T
--------
I
T
E
-
A
E
-
Y
--
D
-
I
D
-
A
A
W
Q
C
I
E
Y
Y
A
G
L
A
P
T
L
S
-
G
Q
H
I
Q
L
----
P
G
G
---
A
F
A
Y
T
R
R
E
P
L
G
--
V
C
A
G
I
L
A
W
N
Y
P
F
M
I
A
A
W
K
C
A
P
A
L
A
C
G
N
A
V
V
F
K
P
S
P
M
T
P
V
T
-
G
V
I
L
A
E
I
F
H
E
----
A
G
V
P
V
G
L
V
N
V
V
Q
G
G
A
-
E
-
T
-
G
S
L
L
C
---
H
--
H
PN
V
A
K
V
S
F
T
G
S
V
P
T
G
K
K
V
M
E
M
S
A
------
K
-
T
V
K
-
H
V
T
L
E
L
G
G
K
S
P
L
L
I
F
K
D
C
E
L
E
N
A
V
R
G
A
L
M
A
N
F
L
T
Q
G
Q
V
C
T
N
G
T
R
V
F
V
Q
R
E
I
M
P
Q
F
L
E
E
V
V
K
R
T
K
A
I
V
V
G
D
P
L
L
T
-
E
T
R
M
G
G
L
I
S
K
P
Q
L
D
K
V
L
G
F
V
A
Q
A
K
K
E
G
-
A
-
R
V
L
C
G
G
E
P
--
L
T
P
SDPK--
L
--
K
N
G
Y
F
M
S
P
C
V
L
D
N
C
R
D
D
M
T
C
V
K
E
E
I
F
G
P
V
M
S
V
L
P
F
D
T
--
E
E
E
V
L
Q
R
A
N
N
T
T
F
G
L
A
S
G
V
F
T
R
D
I
S
R
A
H
R
V
A
A
N
L
E
A
G
T
C
Y
I
N
T
Y
S
I
S
--
P
V
-
E
V
P
F
G
G
Y
K
M
S
G
F
-
G
-
R
E
N
G
-
Q
A
T
V
D
Y
Y
S
Q
L
K
T
V
I
V
E
M
G
D
V
-----------
52
HHSearch
95.12
26%
-91.32
- C5 -
2O2P
9
AL1L1_RAT
A:
[52-516]
-----------------------------
K
T
Y
N
T
I
N
P
-
T
-
D
G
S
V
I
C
Q
V
S
L
A
Q
V
S
D
V
D
K
A
V
A
A
A
----
K
E
A
F
---
E
NG---
L
--
W
G
K
I
N
A
R
D
R
G
R
L
L
Y
R
L
A
D
V
M
E
Q
H
Q
E
E
L
A
T
I
E
A
L
D
A
G
A
--
V
--------
Y
T
L
-
A
L
K
T
--
H
-
V
G
-
M
S
I
Q
T
F
R
Y
F
A
G
W
C
D
K
I
Q
-
G
A
T
I
P
I
N
QAR
P
N
R
---
N
L
T
L
T
K
K
E
P
V
G
--
V
C
G
I
V
I
P
W
N
Y
P
L
M
M
L
S
W
K
T
A
A
C
L
A
A
G
N
T
V
V
I
K
P
A
Q
V
T
P
L
T
-
A
L
K
F
A
E
L
T
L
K
----
A
G
I
P
K
G
V
V
N
I
L
P
G
S
G
S
L
-
V
-
G
Q
R
L
S
---
D
--
H
PD
V
R
K
I
G
F
T
G
S
T
E
V
G
K
H
I
M
K
S
C
A
L
-----
S
-
N
V
K
-
K
V
S
L
E
L
G
G
K
S
P
L
I
I
F
A
D
C
D
L
N
K
A
V
Q
M
G
M
S
S
V
F
F
N
K
G
E
N
C
I
A
A
G
R
L
F
V
E
E
S
I
H
N
Q
F
V
Q
K
V
V
E
E
V
E
K
M
K
I
G
N
P
L
E
R
-
D
T
N
H
G
P
Q
N
H
E
A
H
L
R
K
L
V
E
Y
C
Q
R
G
V
K
E
G
-
A
-
T
L
V
C
G
G
N
Q
--
V
P
----------
R
P
G
F
F
F
Q
P
T
V
F
T
D
V
E
D
H
M
Y
I
A
K
E
E
S
F
G
P
I
M
I
I
S
R
F
A
D
GD
V
D
A
V
L
S
R
A
N
A
T
E
F
G
L
A
S
G
V
F
T
R
D
I
N
K
A
L
Y
V
S
D
K
L
Q
A
G
T
V
F
I
N
T
Y
N
K
--
T
D
V
-
A
A
P
F
G
G
F
K
Q
S
G
F
-
G
-
K
D
L
G
-
E
A
A
L
N
E
Y
L
R
I
K
T
V
T
F
E
---------------
42
HHSearch
94.61
29%
-92.77
* C5 *
3EK1
2
?
A:
[47-502]
----------------------------
G
T
T
I
K
V
T
N
P
-
A
-
D
G
S
V
I
G
T
V
P
S
L
S
V
A
T
I
K
E
A
I
D
A
S
----
A
K
A
L
---
S
-----
G
--
W
A
A
K
T
A
K
E
R
A
G
I
L
R
K
W
F
D
L
I
I
A
N
A
D
D
I
A
L
I
M
T
S
E
Q
G
K
--
P
--------
L
A
E
-
A
R
-
G
--
E
-
V
L
-
Y
A
A
S
F
I
E
W
F
A
E
E
A
K
R
V
Y
-
G
D
T
I
P
A
P
---
Q
N
G
---
Q
R
L
T
V
I
R
Q
P
V
G
--
V
T
A
A
I
T
P
W
N
F
P
A
A
M
I
T
R
K
A
A
P
A
L
A
A
G
C
T
M
I
V
R
P
A
D
L
T
P
L
T
-
A
L
A
L
G
V
L
A
E
K
----
A
G
I
P
A
G
V
L
Q
I
V
T
G
K
A
R
E
-
I
-
G
A
E
L
T
---
S
--
N
DT
V
R
K
L
S
F
T
G
S
T
E
V
G
R
L
L
M
A
Q
C
A
------
P
-
T
I
K
-
R
I
S
L
E
L
G
G
N
A
P
F
I
V
F
D
D
A
D
L
D
A
A
V
D
G
A
M
V
S
K
Y
R
N
A
G
Q
T
C
V
C
A
N
R
I
Y
V
Q
R
G
V
Y
D
K
F
A
E
K
L
A
A
K
V
K
E
L
K
V
G
N
G
T
E
P
-
G
V
V
I
G
P
M
I
E
E
K
A
I
T
K
V
K
A
H
I
E
D
A
V
S
K
G
-
A
-
K
L
I
T
G
G
K
E
--
L
------------
G
G
L
F
F
E
P
G
I
L
T
G
V
T
S
D
M
L
V
A
K
E
E
T
F
G
P
L
A
P
L
F
A
F
D
T
--
E
E
E
V
I
A
Q
A
N
D
T
I
F
G
L
A
A
Y
F
Y
T
E
N
F
S
R
A
I
R
V
S
E
A
L
E
Y
G
M
V
G
H
N
T
G
L
I
S
--
N
E
-
V
A
P
F
G
G
V
K
Q
S
G
L
-
G
-
R
E
G
S
-
K
Y
G
I
E
E
Y
L
E
T
K
Y
I
C
S
A
Y
--------------
44
HHSearch
94.47
28%
-90.71
- C5 -
1O04
2
ALDH2_HUMAN
A:
[34-495]
----------------------------
R
K
T
F
P
T
V
N
P
-
S
-
T
G
E
V
I
C
Q
V
A
E
G
D
K
E
D
V
D
K
A
V
K
A
A
----
R
A
A
F
---
Q
LGS--
P
--
W
R
R
M
D
A
S
H
R
G
R
L
L
N
R
L
A
D
L
I
E
R
D
R
T
Y
L
A
A
L
E
T
L
D
N
G
K
--
P
--------
Y
V
I
-
S
Y
-
L
V-
D
-
L
D
-
M
V
L
K
C
L
R
Y
Y
A
G
W
A
D
K
Y
H
-
G
K
T
I
P
I
D
----
G
D
---
F
F
S
Y
T
R
H
E
P
V
G
--
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
Q
A
W
K
L
G
P
A
L
A
T
G
N
V
V
V
M
K
V
A
E
Q
T
P
L
T
-
A
L
Y
V
A
N
L
I
K
E
----
A
G
F
P
P
G
V
V
N
I
V
P
G
F
G
P
T
-
A
-
G
A
A
I
A
---
S
--
H
ED
V
D
K
V
A
F
T
G
S
T
E
I
G
R
V
I
Q
V
A
A
G
S
-----
S
-
N
L
K
-
R
V
T
L
E
L
G
G
K
S
P
N
I
I
M
S
D
A
D
M
D
W
A
V
E
Q
A
H
F
A
L
F
F
N
Q
G
Q
C
S
C
A
G
S
R
T
F
V
Q
E
D
I
Y
D
E
F
V
E
R
S
V
A
R
A
K
S
R
V
V
G
N
P
F
D
S
-
K
T
E
Q
G
P
Q
V
D
E
T
Q
F
K
K
I
L
G
Y
I
N
T
G
K
Q
E
G
-
A
-
K
L
L
C
G
G
G
I
--
A
A
----------
D
R
G
Y
F
I
Q
P
T
V
F
G
D
V
Q
D
G
M
T
I
A
K
E
E
I
F
G
P
V
M
Q
I
L
K
F
K
T
--
I
E
E
V
V
G
R
A
N
N
S
T
Y
G
L
A
A
A
V
F
T
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
G
T
V
W
V
N
C
Y
D
V
--
F
G
A
-
Q
S
P
F
G
G
Y
K
M
S
G
S
-
G
-
R
E
L
G
-
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
T
V
K
V
--------------
49
HHSearch
93.71
26%
-86.76
- C5 -
1UZB
5
?
A:
[50-515]
----------------------------
K
E
R
M
V
S
L
N
P
S
A
-
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
----
W
K
A
F
---
K
-----
T
--
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
--
N
--------
W
V
E
-
A
S
-
A
--
D
-
V
A
-
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
R
Y
P
A
V
E
V
V
P
---
Y
P
G
---
E
D
N
E
S
F
Y
V
P
L
G
--
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
-
G
A
K
V
F
E
I
F
H
E
----
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
-
V
-
G
A
Y
L
V
---
E
--
H
PR
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
A
A
G
RLAPGQ
T
-
W
F
K
-
R
A
Y
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
-
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
-
Q
-
L
V
L
-
G
G
K
R
--
L
--------
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
K
A
R
I
A
Q
E
E
I
F
G
P
V
L
S
V
I
R
V
K
D
--
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
-
V
Q
P
F
G
G
F
K
L
S
G
T
-
N
-
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
E
R
---------------
1
PsiBlast
93.71
32%
-89.08
- C5 -
2OPX
3
ALDA_ECOLI
A:
[24-479]
-------------------------------
I
D
V
V
N
P
-
A
-
T
----
E
A
V
I
S
R
I
P
D
G
Q
A
E
D
A
R
K
A
I
D
A
A
E
R
A
Q
---
P
-----
E
--
W
E
A
L
P
A
I
E
R
A
S
W
L
R
K
I
S
A
G
I
R
E
R
A
T
E
I
S
A
L
I
V
E
E
G
G
K
--
I
Q
Q
L
A
E
V
E
V
A
F
T
-
A
--
D
--
Y
-
I
D
-
Y
M
A
E
W
A
R
R
Y
E
G
---
E
I
I
Q
S
D
R
P
G
E
N
---
I
-----
L
L
F
K
R
A
L
---
G
--
V
T
T
G
I
L
P
W
N
F
P
F
F
L
I
A
R
K
M
A
P
A
L
L
T
G
N
T
I
V
I
K
P
S
E
F
T
P
N
N
-
A
I
A
F
A
K
I
V
D
E
----
I
G
L
P
R
G
V
F
N
L
V
L
G
R
G
-
E
-
T
V
G
Q
E
L
A
---
G
NP
K
--
V
A
M
V
S
M
T
G
S
V
S
A
G
E
K
I
M
A
T
A
A
------
K
-
N
I
T
-
K
V
C
L
E
L
G
G
K
A
P
A
I
V
M
D
D
A
D
L
E
L
A
V
K
A
I
V
D
S
R
V
I
N
S
G
Q
V
C
N
C
A
E
R
V
Y
V
Q
K
G
I
Y
D
Q
F
V
N
R
L
G
E
A
M
Q
A
V
Q
F
G
N
P
A
E
R
N
D
I
A
M
G
P
L
I
N
A
A
A
L
E
R
V
E
Q
K
V
A
R
A
V
E
E
G
-
A
-
R
V
A
L
G
G
K
A
--
V
E
----------
G
K
G
Y
Y
Y
P
P
T
L
L
L
D
V
R
Q
E
M
S
I
M
H
E
E
T
F
G
P
V
L
P
V
V
A
F
D
T
--
L
E
E
A
I
S
M
A
N
D
S
D
Y
G
L
T
S
S
I
Y
T
Q
N
L
N
V
A
M
K
A
I
K
G
L
K
F
G
E
T
Y
I
N
R
E
N
F
E
A
M
---
Q
G
F
H
A
G
W
R
K
S
G
I
G
G
-
A
D
-
G
-
K
H
G
L
H
E
Y
L
Q
T
Q
V
V
Y
L
Q
S
--------------
2
PsiBlast
93.42
32%
-88.28
- C5 -
2HG2
2
ALDA_ECOLI
A:
[24-479]
-------------------------------
I
D
V
V
N
P
-
A
-
T
----
E
A
V
I
S
R
I
P
D
G
Q
A
E
D
A
R
K
A
I
D
A
A
E
R
A
Q
---
P
-----
E
--
W
E
A
L
P
A
I
E
R
A
S
W
L
R
K
I
S
A
G
I
R
E
R
A
S
E
I
S
A
L
I
V
E
E
G
G
K
--
I
Q
Q
L
A
E
V
E
V
A
F
T
-
A
--
D
--
Y
-
I
D
-
Y
M
A
E
W
A
R
R
Y
E
G
---
E
I
I
Q
S
D
R
P
G
E
N
---
I
-----
L
L
F
K
R
A
L
---
G
--
V
T
T
G
I
L
P
W
N
F
P
F
F
L
I
A
R
K
M
A
P
A
L
L
T
G
N
T
I
V
I
K
P
S
E
F
T
P
N
N
-
A
I
A
F
A
K
I
V
D
E
----
I
G
L
P
R
G
V
F
N
L
V
L
G
R
G
-
E
-
T
V
G
Q
E
L
A
---
G
NP
K
--
V
A
M
V
S
M
T
G
S
V
S
A
G
E
K
I
M
A
T
A
A
------
K
-
N
I
T
-
K
V
C
L
E
L
G
G
K
A
P
A
I
V
M
D
D
A
D
L
E
L
A
V
K
A
I
V
D
S
R
V
I
N
S
G
Q
V
C
N
C
A
E
R
V
Y
V
Q
K
G
I
Y
D
Q
F
V
N
R
L
G
E
A
M
Q
A
V
Q
F
G
N
P
A
E
R
N
D
I
A
M
G
P
L
I
N
A
A
A
L
E
R
V
E
Q
K
V
A
R
A
V
E
E
G
-
A
-
R
V
A
F
G
G
K
A
--
V
E
----------
G
K
G
Y
Y
Y
P
P
T
L
L
L
D
V
R
Q
E
M
S
I
M
H
E
E
T
F
G
P
V
L
P
V
V
A
F
D
T
--
L
E
D
A
I
S
M
A
N
D
S
D
Y
G
L
T
S
S
I
Y
T
Q
N
L
N
V
A
M
K
A
I
K
G
L
K
F
G
E
T
Y
I
N
R
E
N
F
E
A
M
---
Q
G
F
H
A
G
W
R
K
S
G
I
G
G
-
A
D
-
G
-
K
H
G
L
H
E
Y
L
Q
T
Q
V
V
Y
L
Q
S
--------------
51
HHSearch
93.33
28%
-99.55
- C5 -
3R64
-
?
A:
[28-493]
-----------------------------
R
I
S
T
N
I
N
P
-
Y
-
D
D
S
V
I
A
E
S
K
Q
A
S
I
A
D
V
D
A
A
Y
E
A
A
----
K
K
A
Q
---
A
-----
E
--
W
A
A
T
P
A
A
E
R
S
A
I
I
Y
R
A
A
E
L
L
E
E
H
R
E
E
I
V
E
W
L
I
K
E
S
G
S
--
T
--------
R
S
K
-
A
N
-
L
--
E
-
I
T
-
L
A
G
N
I
T
K
E
S
A
S
F
P
G
R
V
H
-
G
R
I
S
P
S
N
---
T
P
G
---
K
E
N
R
V
Y
R
V
A
K
G
--
V
V
G
V
I
S
P
W
N
F
P
L
N
L
S
I
R
S
V
A
P
A
L
A
V
G
N
A
V
V
I
K
P
A
S
D
T
P
V
T
G
G
V
I
P
A
R
I
F
E
E
----
A
G
V
P
A
G
V
I
S
T
V
A
G
A
G
S
E
-
I
-
G
D
H
F
V
---
T
--
H
AV
P
K
L
I
S
F
T
G
S
T
P
V
G
R
R
V
G
E
L
A
I
N
G----
G
-
P
M
K
-
T
V
A
L
E
L
G
G
N
A
P
F
V
V
L
A
D
A
D
I
D
A
A
A
Q
A
A
A
V
G
A
F
L
H
Q
G
Q
I
C
M
S
I
N
R
V
I
V
D
A
A
V
H
D
E
F
L
E
K
F
V
E
A
V
K
N
I
P
T
G
D
P
S
A
E
-
G
T
L
V
G
P
V
I
N
D
S
Q
L
S
G
L
K
E
K
I
E
L
A
K
K
E
G
-
A
-
T
V
Q
V
E
G
P
I
---------------
E
G
R
L
V
H
P
H
V
F
S
D
V
T
S
D
M
E
I
A
R
E
E
I
F
G
P
L
I
S
V
L
K
A
D
D
--
E
A
H
A
A
E
L
A
N
A
S
D
F
G
L
S
A
A
V
W
S
K
D
I
D
R
A
A
Q
F
A
L
Q
I
D
S
G
M
V
H
I
N
D
------------------------
R
F
N
G
-
D
W
A
I
E
E
F
T
T
D
R
W
I
G
I
K
R
--
S
A
E
N
L
-
Y
F
Q
---
53
HHSearch
93.21
29%
-91.23
- C5 -
3R31
1
BETB_AGRT5
A:
[30-489]
-----------------------------
T
P
F
E
S
I
F
P
-
A
-
T
G
E
M
I
A
K
L
H
A
A
T
P
A
I
V
E
R
A
I
A
S
A
----
K
R
A
Q
---
K
-----
E
--
W
A
A
M
S
P
M
A
R
G
R
I
L
K
R
A
A
D
I
M
R
E
R
N
D
A
L
S
T
L
E
T
L
D
T
G
K
--
P
--------
I
Q
E
-
T
I
V
A
--
D
-
P
T
-
S
G
A
D
A
F
E
F
F
G
G
I
A
P
S
A
L
N
G
D
Y
I
P
L
G
-----
G
---
D
F
A
Y
T
K
R
V
P
L
G
--
V
C
V
G
I
G
A
W
N
Y
P
Q
Q
I
A
C
W
K
A
A
P
A
L
V
A
G
N
A
M
V
F
K
P
S
E
N
T
P
L
G
-
A
L
K
I
A
E
I
L
I
E
----
A
G
L
P
K
G
L
F
N
V
I
Q
G
D
R
-
D
-
T
-
G
P
L
L
V
---
N
--
H
PD
V
A
K
V
S
L
T
G
S
V
P
T
G
R
K
V
A
A
A
A
A
------
G
-
H
L
K
-
H
V
T
M
E
L
G
G
K
S
P
M
I
V
F
D
D
A
D
I
E
S
A
V
G
G
A
M
L
G
N
F
Y
S
S
G
Q
V
C
S
N
G
T
R
V
F
V
Q
K
K
A
K
A
R
F
L
E
N
L
K
R
R
T
E
A
M
I
L
G
D
P
L
D
Y
-
A
T
H
L
G
P
L
V
S
K
A
Q
Q
E
K
V
L
S
Y
I
E
K
G
K
A
E
G
-
A
-
T
L
I
T
G
G
G
I
--
P
N
-------
N
VA
G
E
G
A
Y
V
Q
P
T
V
F
A
D
V
T
D
D
M
T
I
A
R
E
E
I
F
G
P
V
M
C
V
L
D
F
D
D
--
E
D
E
V
L
A
R
A
N
A
T
E
F
G
L
A
G
G
V
F
T
A
D
L
A
R
A
H
R
V
V
D
G
L
E
A
G
T
L
W
I
N
T
Y
N
L
--
C
P
V
-
E
I
P
F
G
G
S
K
Q
S
G
F
-
G
-
R
E
N
S
-
A
A
A
L
E
H
Y
S
E
L
K
T
V
Y
V
S
T
G
-------------
54
HHSearch
93.10
25%
-87.74
- C5 -
3QAN
-
ROCA1_BACHD
A:
[50-516]
----------------------------
E
D
K
I
Q
S
W
N
P
-
A
R
K
D
Q
L
V
G
S
V
S
K
A
N
Q
D
L
A
E
K
A
I
Q
S
A
----
D
E
A
F
---
Q
-----
T
--
W
R
N
V
N
P
E
E
R
A
N
I
L
V
K
A
A
A
I
I
R
R
R
K
H
E
F
S
A
W
L
V
H
E
A
G
K
--
P
--------
W
K
E
-
A
D
-
A
--
D
-
T
A
-
E
A
I
D
F
L
E
Y
Y
A
R
Q
M
I
E
L
N
R
G
K
E
I
L
-
S
---
R
P
G
---
E
Q
N
R
Y
F
Y
T
P
M
G
--
V
T
V
T
I
S
P
W
N
F
A
L
A
I
M
V
G
T
A
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
T
T
P
V
V
-
A
A
K
F
V
E
V
L
E
D
----
A
G
L
P
K
G
V
I
N
Y
V
P
G
S
G
A
E
-
V
-
G
D
Y
L
V
---
D
--
H
PK
T
S
L
I
T
F
T
G
S
K
D
V
G
V
R
L
Y
E
R
A
A
VVRPGQ
N
-
H
L
K
-
R
V
I
V
E
M
G
G
K
D
T
V
V
V
D
R
D
A
D
L
D
L
A
A
E
S
I
L
V
S
A
F
G
F
S
G
Q
K
C
S
A
G
S
R
A
V
I
H
K
D
V
Y
D
E
V
L
E
K
T
V
A
L
A
K
N
L
T
V
G
D
P
T
N
R
-
D
N
Y
M
G
P
V
I
D
E
K
A
F
E
K
I
M
S
Y
I
E
I
G
K
K
E
G
---
R
L
M
T
G
G
E
G
--
D
--------
S
--
S
T
G
F
F
I
Q
P
T
I
I
A
D
L
D
P
E
A
V
I
M
Q
E
E
I
F
G
P
V
V
A
F
S
K
A
N
D
--
F
D
H
A
L
E
I
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
R
N
R
A
H
I
E
Q
A
K
R
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
-
Y
H
P
F
G
G
F
K
M
S
G
T
D
S
-
K
A
G
G
-
P
D
Y
L
A
L
H
M
Q
A
K
T
V
S
E
M
Y
--------------
31
SP3
93.09
24%
-87.52
- C5 -
1WNB
1
ABDH_ECOLI
A:
[22-495]
-------------M
Q
H
K
L
L
I
NG
E
L
V
S
G
E
G
E
K
Q
P
V
Y
N
P
-
A
-
T
G
D
V
L
L
E
I
A
E
A
S
A
E
Q
V
D
A
A
V
R
A
A
----
D
A
A
F
---
A
-----
E
--
W
G
Q
T
T
P
K
V
R
A
E
C
L
L
K
L
A
D
V
I
E
E
N
G
Q
V
F
A
E
L
E
S
R
N
C
G
K
--
P
--------
L
H
S
-
A
--
F
N
D
E
-
I
P
-
A
I
V
D
V
F
R
F
F
A
G
A
A
R
C
L
N
G
L
A
A
G
E
Y
L
---
E
G
----
H
T
S
M
I
R
R
D
P
L
G
--
V
V
A
S
I
A
P
W
N
Y
P
L
M
M
A
A
W
K
L
A
P
A
L
A
A
G
N
C
V
V
L
K
P
S
E
I
T
P
L
T
-
A
L
K
L
A
E
L
A
K
D
----
I
-
F
P
A
G
V
V
N
I
L
F
G
R
G
-
K
T
V
-
G
D
P
L
T
---
G
--
H
PK
V
R
M
V
S
L
T
G
S
I
A
T
G
E
H
I
I
S
H
T
A
------
S
-
S
I
K
-
R
T
H
M
E
L
G
G
K
A
P
V
I
V
F
D
D
A
D
I
E
A
V
V
E
G
V
R
T
F
G
Y
Y
N
A
G
Q
D
C
T
A
A
C
R
I
Y
A
Q
K
G
I
Y
D
T
L
V
E
K
L
G
A
A
V
A
T
L
K
S
G
A
P
D
D
E
-
S
T
E
L
G
P
L
S
S
L
A
H
L
E
R
V
G
K
A
V
E
E
A
K
A
T
G
H
I
-
K
V
I
T
G
G
E
K
--
R
K
----------
G
N
G
Y
Y
Y
A
P
T
L
L
A
G
A
L
Q
D
D
A
I
V
Q
K
E
V
F
G
P
V
V
S
V
T
P
F
D
N
--
E
E
Q
V
V
N
W
A
N
D
S
Q
Y
G
L
A
S
S
V
W
T
K
D
V
G
R
A
H
R
V
S
A
R
L
Q
Y
G
C
T
W
V
N
T
H
F
M
L
--
V
S
-
E
M
P
H
G
G
Q
K
L
S
G
Y
-
G
-
K
D
M
S
-
L
Y
G
L
E
D
Y
T
V
V
R
H
V
M
V
K
H
--------------
43
HHSearch
92.44
25%
-85.52
- C5 -
1WND
1
ABDH_ECOLI
A:
[37-495]
----------------------------
G
E
K
Q
P
V
Y
N
P
-
A
-
T
G
D
V
L
L
E
I
A
E
A
S
A
E
Q
V
D
A
A
V
R
A
A
----
D
A
A
F
---
A
-----
E
--
W
G
Q
T
T
P
K
V
R
A
E
C
L
L
K
L
A
D
V
I
E
E
N
G
Q
V
F
A
E
L
E
S
R
N
C
G
K
--
P
--------
L
H
S
-
A
--
F
N
-
D
-
E
I
P
A
I
V
D
V
F
R
F
F
A
G
A
A
R
C
L
-
N
G
L
A
A
G
E
Y
---
L
E
G
---
H
T
S
M
I
R
R
D
P
L
G
--
V
V
A
S
I
A
P
W
N
Y
P
L
M
M
A
A
W
K
L
A
P
A
L
A
A
G
N
C
V
V
L
K
P
S
E
I
T
P
L
T
-
A
L
K
L
A
E
L
A
K
D
-----
I
F
P
A
G
V
V
N
I
L
F
G
R
G
K
T
-
V
-
G
D
P
L
T
---
G
--
H
PK
V
R
M
V
S
L
T
G
S
I
A
T
G
E
H
I
I
S
H
T
A
------
S
-
S
I
K
-
R
T
H
M
E
L
G
G
K
A
P
V
I
V
F
D
D
A
D
I
E
A
V
V
E
G
V
R
T
F
G
Y
Y
N
A
G
Q
D
C
T
A
A
C
R
I
Y
A
Q
K
G
I
Y
D
T
L
V
E
K
L
G
A
A
V
A
T
L
K
S
G
A
P
D
D
E
-
S
T
E
L
G
P
L
S
S
L
A
H
L
E
R
V
G
K
A
V
E
E
A
K
A
T
G
-
H
I
K
V
I
T
G
G
E
K
--
R
--------
K
--
G
N
G
Y
Y
Y
A
P
T
L
L
A
G
A
L
Q
D
D
A
I
V
Q
K
E
V
F
G
P
V
V
S
V
T
P
F
D
N
--
E
E
Q
V
V
N
W
A
N
D
S
Q
Y
G
L
A
S
S
V
W
T
K
D
V
G
R
A
H
R
V
S
A
R
L
Q
Y
G
C
T
W
V
N
T
H
F
M
L
--
V
S
-
E
M
P
H
G
G
Q
K
L
S
G
Y
-
G
-
K
D
M
S
-
L
Y
G
L
E
D
Y
T
V
V
R
H
V
M
V
K
H
--------------
48
HHSearch
92.42
21%
-88.85
- C5 -
1T90
1
IOLA_BACSU
A:
[20-482]
----------------------------
D
Q
Y
E
D
V
V
N
P
-
A
-
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
----
A
E
A
F
---
K
-----
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
--
N
--------
T
K
E
-
A
L
-
G
--
E
-
V
G
-
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
-
M
G
D
S
L
A
S
I
---
A
T
D
---
V
E
A
A
N
Y
R
Y
P
I
G
--
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
-
T
E
K
L
V
E
L
F
E
K
----
A
G
L
P
K
G
V
F
N
V
V
Y
G
A
H
-
D
-
V
-
V
N
G
I
L
---
E
--
H
PE
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
------
E
-
N
L
K
-
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
-
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
-
A
-
R
L
V
C
D
G
R
E
--
N
V
-------
S
--
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
--
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
-
P
M
A
-
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
A
N
G
-
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
------------
57
HHSearch
92.15
27%
-94.27
- C5 -
3PQA
2
LADH_METJA
A:
[14-464]
-------------------------------
M
D
V
I
N
P
-
Y
-
S
L
E
V
I
K
K
I
P
A
L
S
R
E
E
A
K
E
A
I
D
T
A
----
E
K
Y
K
---
E
-----
V
--
M
K
N
L
P
I
T
K
R
Y
N
I
L
M
N
I
A
K
Q
I
K
E
K
K
E
E
L
A
K
I
L
A
I
D
A
G
K
--
P
--------
I
K
Q
-
A
R
-
V
--
E
-
V
E
-
R
S
I
G
T
F
K
L
A
A
F
Y
V
K
E
H
R
D
E
-
V
I
P
S
D
-----
D
---
R
L
I
F
T
R
R
E
P
V
G
--
I
V
G
A
I
T
P
F
N
F
P
L
N
L
S
A
H
K
I
A
P
A
I
A
T
G
N
V
I
V
H
H
P
S
S
K
A
P
L
V
-
C
I
E
L
A
K
I
I
E
N
A
L
K
K
Y
N
V
P
L
G
V
Y
N
L
L
T
G
A
G
E
V
-
V
-
G
D
E
I
V
---
V
--
N
EK
V
N
M
I
S
F
T
G
S
S
K
V
G
E
L
I
T
K
K
A
G
---------
F
K
-
K
I
A
L
E
L
G
G
V
N
P
N
I
V
L
K
D
A
D
L
N
K
A
V
N
A
L
I
K
G
S
F
I
Y
A
G
Q
V
C
I
S
V
G
M
I
L
V
D
E
S
I
A
D
K
F
I
E
M
F
V
N
K
A
K
V
L
N
V
G
N
P
L
D
E
-
K
T
D
V
G
P
L
I
S
V
E
H
A
E
W
V
E
K
V
V
E
K
A
I
D
E
G
-
G
-
K
L
L
L
G
G
K
R
---------------
D
K
A
L
F
Y
P
T
I
L
E
-
V
D
R
D
N
I
L
C
K
T
E
T
F
A
P
V
I
P
I
I
R
-
T
N
--
E
E
E
M
I
D
I
A
N
S
T
E
Y
G
L
H
S
A
I
F
T
N
D
I
N
K
S
L
K
F
A
E
N
L
E
F
G
G
V
V
I
N
D
S
S
L
F
--
R
Q
D
N
M
P
F
G
G
V
K
K
S
G
L
-
G
-
R
E
G
V
-
K
Y
A
M
E
E
M
S
N
I
K
T
I
I
I
S
K
--------------
58
HHSearch
91.54
26%
-77.82
- C5 -
3I44
3
?
A:
[41-496]
-----------------------------
H
D
L
Y
V
I
D
P
-
S
-
T
E
E
A
C
A
V
I
S
L
G
S
T
R
D
A
D
K
A
I
N
A
A
----
K
K
A
F
---
Q
-----
T
--
W
K
T
T
S
P
H
E
R
L
G
F
V
E
K
I
L
E
I
Y
E
K
R
S
S
D
M
A
K
T
I
S
M
E
M
G
A
--
P
--------
I
D
M
-
A
--
L
--
N
-
A
Q
-
T
A
T
G
S
S
H
I
-
R
N
F
I
K
A
Y
-
K
E
F
S
F
Q
E
A
----
L
I
EGN
E
Q
A
I
L
H
Y
D
A
I
G
--
V
V
G
L
I
T
P
W
N
W
P
M
N
Q
V
T
L
K
V
I
P
A
L
L
A
G
C
T
M
V
L
K
P
S
E
I
A
P
L
S
-
A
M
L
F
A
E
I
L
D
E
----
A
A
L
P
S
G
V
F
N
L
I
N
G
D
G
A
N
-
V
-
G
S
Y
L
S
---
A
--
H
PD
L
E
M
I
S
F
T
G
S
T
R
A
G
K
D
I
S
K
N
A
S
------
N
-
T
L
K
-
R
V
C
L
E
L
G
G
K
G
A
N
I
I
F
A
D
A
D
I
D
-
A
L
Q
R
G
V
R
H
C
F
Y
N
S
G
Q
S
C
N
A
P
T
R
M
L
V
E
Q
A
I
Y
D
K
A
I
K
T
A
K
D
I
A
E
K
T
Q
V
G
P
G
H
Q
T
-
G
N
H
I
G
P
V
V
S
K
E
Q
Y
D
K
I
Q
D
L
I
Q
S
G
I
D
E
G
-
A
-
T
L
V
T
G
G
T
G
--
L
P
-------
M
GM
E
R
G
Y
Y
V
R
P
T
V
F
A
D
V
K
P
H
M
R
I
F
R
E
E
I
F
G
P
V
L
S
L
L
P
F
N
T
--
E
D
E
A
V
T
L
A
N
D
T
E
Y
G
L
T
N
Y
I
Q
S
Q
D
R
S
K
C
R
R
I
A
A
Q
V
R
S
G
M
V
E
V
N
G
H
---
E
L
P
G
-
G
S
Y
F
G
G
V
K
F
S
G
R
-
A
-
R
E
G
G
-
L
W
G
I
K
E
F
L
D
T
K
A
I
S
Y
----------------
User Run . : Multi Template Modeling Result:
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTKTIEVRNPRTGKFDYVIIPPPPRLLAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGRLSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRDVLIFVEGGGETGANLINYVDFVCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEKNAFNFSGLGGSRVGAAGLKRFLRKQAFLIKTNSTSDPWWFDKGD
70
67.02
100%
-13.91
- C- -
M070
-
A:
[2-490]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
64
65.72
100%
-12.87
- C- -
M064
-
A:
[2-499]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
80
65.30
100%
-14.67
- C- -
M080
-
A:
[2-487]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
59
65.17
100%
-19.26
- C- -
M059
-
A:
[2-499]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
63
65.13
100%
-13.54
- C- -
M063
-
A:
[2-494]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
61
64.96
100%
-20.06
- C- -
M061
-
A:
[2-494]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
60
63.90
100%
-20.07
- C- -
M060
-
A:
[2-491]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
79
63.84
100%
-17.11
- C- -
M079
-
A:
[2-492]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
78
63.56
100%
-19.22
- C- -
M078
-
A:
[2-487]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
82
63.38
100%
-12.07
- C- -
M082
-
A:
[2-496]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
77
63.30
100%
-17.77
- C- -
M077
-
A:
[2-496]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
71
63.19
100%
-17.32
- C- -
M071
-
A:
[2-531]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
62
63.17
100%
-14.15
- C- -
M062
-
A:
[2-491]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
65
63.00
100%
-17.58
- C- -
M065
-
A:
[2-490]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
81
61.75
100%
-12.64
- C- -
M081
-
A:
[2-492]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
76
61.43
100%
-15.17
- C- -
M076
-
A:
[2-531]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
75
61.12
100%
-12.03
- C- -
M075
-
A:
[2-491]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
73
60.50
100%
-18.63
- C- -
M073
-
A:
[2-491]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
68
60.27
100%
-16.26
- C- -
M068
-
A:
[3-485]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
66
59.32
100%
-21.98
- C- -
M066
-
A:
[3-485]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
67
58.54
100%
-19.21
- C- -
M067
-
A:
[3-490]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
69
57.19
100%
-9.80
- C- -
M069
-
A:
[3-490]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
74
55.71
100%
-14.20
- C- -
M074
-
A:
[3-491]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D
72
54.07
100%
-17.83
- C- -
M072
-
A:
[3-491]
M
T
K
T
I
E
V
R
N
P
R
T
G
K
F
D
Y
V
I
I
P
P
P
P
R
L
L
A
Q
Q
C
N
R
A
R
R
A
Q
S
R
W
Q
E
L
G
V
E
G
R
I
T
T
L
Q
Q
W
K
Q
A
I
L
S
R
R
E
Q
L
T
E
A
L
V
N
D
T
G
R
L
S
I
T
V
L
E
I
D
S
F
L
A
S
I
D
R
W
C
G
L
A
P
E
L
L
Q
T
S
A
K
N
T
S
I
P
F
I
A
L
Q
Q
S
L
V
P
Y
P
L
V
G
V
I
S
P
W
N
F
P
L
T
L
S
M
I
D
T
I
P
A
L
L
A
G
C
A
V
V
V
K
P
S
E
I
A
P
R
F
V
A
P
L
L
M
A
L
N
T
V
P
E
L
R
D
V
L
I
F
V
E
G
G
G
E
T
G
A
N
L
I
N
Y
V
D
F
V
C
F
T
G
S
V
A
T
G
R
E
V
A
E
T
A
A
R
R
F
I
P
A
Y
L
E
L
G
G
K
D
P
A
I
V
L
E
S
A
N
L
E
L
A
T
S
A
I
L
W
G
A
V
V
N
T
G
Q
S
C
L
S
I
E
R
I
Y
V
A
E
S
K
F
E
E
F
Y
H
Q
L
I
A
K
A
H
R
L
Q
L
A
Y
P
L
V
E
D
G
A
I
G
P
I
I
A
E
K
Q
A
G
I
I
N
D
H
I
L
D
A
V
E
K
G
A
V
I
H
C
G
G
K
V
E
E
L
G
G
G
W
W
C
R
P
T
V
M
T
N
V
N
H
S
M
K
V
M
T
E
E
T
F
G
P
I
M
P
V
M
P
F
P
D
V
E
E
A
V
Y
L
A
N
D
T
I
Y
G
L
S
A
A
V
F
A
G
S
E
D
E
A
L
K
V
A
R
Q
L
N
A
G
A
I
S
I
N
D
A
A
L
T
A
M
M
H
E
G
E
K
N
A
F
N
F
S
G
L
G
G
S
R
V
G
A
A
G
L
K
R
F
L
R
K
Q
A
F
L
I
K
T
N
S
T
S
D
P
W
W
F
D
K
G
D